Turbinaria conoides (J. Agardh) sulfated polysaccharide protects rat's heart against myocardial injury

Krishnamurthy, Mohankumar; Selvaraju, M.; Manivasagam, Thamilarasan

doi:10.1016/j.ijbiomac.2012.03.012

Cited by 14 publications

(8 citation statements)

References 26 publications

(24 reference statements)

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“…In addition, Chattopadhyay et al [29] have reported that fucoidan from T. conoides could be used as the potential natural antioxidant in food industry. Similarly, Krishnamurthy et al [30] have stated that the fucoidan of T. conoides exhibited the cardio protective effects in rat. These results suggest that the fucoidans of T. conoides showed broad spectrum of biological activities.…”

Section: Discussionmentioning

confidence: 85%

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines

Marudhupandi

Kumar

Lakshmanasenthil³

et al. 2015

International Journal of Biological Macromolecules

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Section: Discussionmentioning

confidence: 85%

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines

Marudhupandi

Kumar

Lakshmanasenthil³

et al. 2015

International Journal of Biological Macromolecules

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“…In addition, studies on fucoidan isolated from Turbinaria spp. have shown therapeutic benefits such as the prevention of myocardial injury, 16 along with hepatoprotective, 17 anticancer 9 and neuroprotective activities 18 . In view of these findings, the present study aims to evaluate the in vitro antioxidant and anti-proliferative effects of T. ornata -hexane extract (To-HE) and T. ornata -aqueous extract (To-AE) against A549 and Vero .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling of Turbinaria ornata and its antioxidant and anti-proliferative effects

Deepak

Sowmiya

Perumal

2017

Journal of Taibah University Medical Sciences

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Objectives To analyse the phytochemicals and evaluate the antioxidant and anti-proliferative ability of Turbinaria ornata (Turner) J. Agardh, 1848. Methods A phytochemical analysis of the T. ornata -hexane extract (To-HE) and T. ornata -aqueous extract (To-AE) was performed. T. ornata extracts were analysed by gas chromatography-mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC). The antioxidant properties of To-HE and To-AE were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH) and ferric ion reducing power (FRAP) assays. In addition, the in vitro anti-proliferative properties of To-HE and To-AE were assessed in kidney epithelial cells from the African green monkey ( Vero ) and in adenocarcinomic human alveolar basal epithelial cells (A549) using the MTT (3-(4,5-dimethylthiazol- 2yl)-2,5-diphenyltetrazolium bromide, a yellow tetrazole) assay. Results The phytochemical screening of T. ornata revealed the presence of saponin, alkaloids, amino acids, fixed oil and fat and phenolic compounds (tannins, flavonoids and total phenol). A higher antioxidant ability was found in To-HE than in To-AE. The anti-proliferative efficacy values (μg/mL) of To-HE and To-AE for A549 and Vero cells were 62.91 and 93.00 and 72.64 and 106.6, respectively. The FTIR analysis revealed the presence of functional groups such as alcohols, amides, aromatics, amines, alkyl halides, alkynes, alkanes and carboxylic acids. The GC-MS analysis of To-HE revealed the presence of 13 active compounds. Conclusion Owing to its recorded anti-proliferative effect, further pharmaceutical studies on the development of this anticancer drug are merited.

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“…51,52 RSV protects primary cultured astrocytes from in vitro ischemiainduced damage. [53][54][55][56] These data suggest that RSV increases NO production from eNOS to exert the antiapoptotic effect of NO, and thus contributes to RSV PLGA NPs cardioprotective effect. On the other hand, under pathological conditions where iNOS expression is stimulated, RSV PLGA NPs inhibits iNOS expression and thus protects tissues from nitrative stress.…”

Section: Discussionmentioning

confidence: 85%

Protective role of poly(lactic‐co‐glycolic) acid nanoparticle loaded with resveratrol against isoproterenol‐induced myocardial infarction

Sun

Mishra

et al. 2020

BioFactors

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Our study is aimed at evaluating the effects of pretreatment with Poly(lactic‐co‐glycolic) acid nanoparticle loaded with resveratrol (RSV PLGA NPs) compared to conventional resveratrol (RSV) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Sixty rats were randomly divided into six groups of 10 rats each. RSV and RSV PLGA NPs were given by gavage in two different doses (50 mg/kg body weight [BW] and 100 mg/kg BW) for 3 weeks. RSV and RSV PLGA NPs were given for 2 weeks starting 1 week before ISO administration. The blood samples were taken 24 hr after the last dose of ISO. The antioxidant, anti‐inflammatory, and cardioprotective effects were evaluated in all groups. Only 100 mg/kg dose of RSV and both doses of RSV PLGA NPs offered a cardioprotective effect by preventing cardiac troponin T (cTnT) levels, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) activities leakage from cardiomyocytes, with the best result for RSV PLGA NPs. All the oxidative stress parameters were significantly improved after RSV PLGA NPs compared to RSV pretreatment. RSV PLGA NPs were more efficient than RSV in limiting the increase in inflammatory cytokine expressions such as tumor necrosis factor‐alpha (TNF‐α), interleukin 1 beta (IL‐1β), and NF‐kappaB (NF‐kB) expression. In addition, RSV PLGA NPs significantly upregulated eNOS expression and downregulated iNOS expression. RSV PLGA NPs better prevented myocardial necrosis and reduced interstitial edema and neutrophil infiltration than RSV, on histopathological examination. Therefore, improving the bioactivity of RSV by nanotechnology may help limit cardiac injury after myocardial infarction.

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Turbinaria conoides (J. Agardh) sulfated polysaccharide protects rat's heart against myocardial injury

Cited by 14 publications

References 26 publications

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines

Phytochemical profiling of Turbinaria ornata and its antioxidant and anti-proliferative effects

Protective role of poly(lactic‐co‐glycolic) acid nanoparticle loaded with resveratrol against isoproterenol‐induced myocardial infarction

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