Tridimensional multiphysics model for the study of photo-induced thermal effects in arbitrary nano-structures

Demésy, Guillaume; Gallais, Laurent; Commandré, Mireille

doi:10.2971/jeos.2011.11037

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…The spatial and temporal evolution of the gold and water temperature was calculated for different laser fluences. More details about the setup of the simulation can be found in Demesy et al The physical properties of gold and water were taken from Ekici et al Properties of the UV glue were provided by the manufacturer.…”

Section: Methodsmentioning

confidence: 99%

Intracellular Delivery Using Nanosecond-Laser Excitation of Large-Area Plasmonic Substrates

Saklayen¹,

Huber

Madrid³

et al. 2017

ACS Nano

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Efficiently delivering functional cargo to millions of cells on the time scale of minutes will revolutionize gene therapy, drug discovery, and high-throughput screening. Recent studies of intracellular delivery with thermoplasmonic structured surfaces show promising results but in most cases require time- or cost-intensive fabrication or lead to unreproducible surfaces. We designed and fabricated large-area (14 × 14 mm), photolithography-based, template-stripped plasmonic substrates that are nanosecond laser-activated to form transient pores in cells for cargo entry. We optimized fabrication to produce plasmonic structures that are ultrasmooth and precisely patterned over large areas. We used flow cytometry to characterize the delivery efficiency of cargos ranging in size from 0.6 to 2000 kDa to cells (up to 95% for the smallest molecule) and viability of cells (up to 98%). This technique offers a throughput of 50000 cells/min, which can be scaled up as necessary. This technique is also cost-effective as each large-area photolithography substrate can be used to deliver cargo to millions of cells, and switching to a nanosecond laser makes the setup cheaper and easier to use. The approach we present offers additional desirable features: spatial selectivity, reproducibility, minimal residual fragments, and cost-effective fabrication. This research supports the development of safer genetic and viral disease therapies as well as research tools for fundamental biological research that rely on effectively delivering molecules to millions of living cells.

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Section: Methodsmentioning

confidence: 99%

Intracellular Delivery Using Nanosecond-Laser Excitation of Large-Area Plasmonic Substrates

Saklayen¹,

Huber

Madrid³

et al. 2017

ACS Nano

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“…Indeed in such highly absorbing defects of nanometric size, plasmonic effects can happen. The investigation of photo-induced thermal effects in arbitrary nanostructures based on the finite element method was discussed by Demésy et al [16]. We give here in Fig.…”

Section: Nature and Size Of Damage Precursorsmentioning

confidence: 99%

Laser-induced damage in composites of scandium, hafnium, aluminum oxides with silicon oxide in the infrared

Fu¹,

Commandré²,

Gallais³

et al. 2014

Appl. Opt.

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The laser-induced damage of mixtures of Sc2O3, HfO2, Al2O3 with SiO2 has been characterized in the infrared for both nanosecond and subpicosecond pulses. Laser-induced damage thresholds (LIDTs) are reported and discussed versus band gap for different compositions. The distributions versus fluence of nanosecond damage precursor densities are extracted fitting damage probability curves. Two models are used: first, a statistical approach, i.e., direct calculation of damage precursor density from damage probability, and second a thermal model based on absorption of initiator. The results show a good agreement. The nature, shape, and size of these precursors are discussed. The critical temperature in the thermal model is dependent on the band gap energy.

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“…To choose treatment parameters properly and to predict the outcome of the photo thermal effect, a reliable tissue model and simulation method is needed. 4 Temperature is the governing parameter of all thermal laser-tissue interactions. Depending on the tissue temperature, different effects are observed.…”

Section: Introductionmentioning

confidence: 99%

Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation

2017

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Introduction: The purpose of this project is to develop a mathematical model to investigate light distribution and study effective parameters such as laser power and irradiated time to get the optimal laser dosage to control hyperthermia. This study is expected to have a positive impact and a better simulation on laser treatment planning of biological tissues. Moreover, it may enable us to replace animal tests with the results of a COMSOL predictive model. Methods: We used in this work COMSOL5 model to simulate the light diffusion and bio-heat equation of the mouse tissue when irradiated by 980 nm laser diode and the effect of different parameters (laser power, and irradiated time) on the surrounding tissue of the tumor treatment in order to prevent damage from excess heat Results: The model was applied to study light propagation and several parameters (laser power, irradiated time) and their impact on light-heat distribution within the tumor in the mouse back tissue The best result is at laser power 0.5 W and time irradiation 0.5 seconds in order to get the maximum temperature hyperthermia at 52°C. Conclusion:The goal of this study is to simulate a mouse model to control excess heating of tissue and reduce the number of animals in experimental research to get the best laser parameters that was safe for use in living animals and in human subjects.

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Tridimensional multiphysics model for the study of photo-induced thermal effects in arbitrary nano-structures

Cited by 6 publications

References 58 publications

Intracellular Delivery Using Nanosecond-Laser Excitation of Large-Area Plasmonic Substrates

Intracellular Delivery Using Nanosecond-Laser Excitation of Large-Area Plasmonic Substrates

Laser-induced damage in composites of scandium, hafnium, aluminum oxides with silicon oxide in the infrared

Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation

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