2009
DOI: 10.1590/s0103-84782009005000230 View full text |Buy / Rent full text
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Abstract: O estudo objetivou realizar ensaio toxicológico pré-clínico inicial para investigar a toxicidade das folhas de alecrim-pimenta (Lippia sidoides Cham.), aroeira (Myracrodruon urundeuva Fr. All.) e barbatimão [Stryphnodendron adstringens (Mart.) Coville] e do farelo da casca de pequi (Caryocar brasiliense Camb.), por meio da determinação da dose letal 50% (DL50). Na investigação da DL50, foram utilizados grupos de camundongos Swiss de mesmo sexo (n=150, sendo 30 animais por tratamento) inoculados, por via intrap… Show more

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“…However, the results in this study are in agreement with the results described by Fontenelle et al (2007) and Almeida et al (2010) despite a difference in methodology.…”
Section: Discussionsupporting
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“…However, the results in this study are in agreement with the results described by Fontenelle et al (2007) and Almeida et al (2010) despite a difference in methodology.…”
Section: Discussionsupporting
“…Studies in literature about effect of acute toxicity of L. origanoides essential oil are scarce but was demonstrated that Lippia sidoides extract, administrated by intraperitoneal way, has a DL50 of 1329,17mg/kg that was considered of high toxicity (Almeida et al 2010). This result is different from showed in this work, but is important highlight that methods and protocols was distinct of those presented in this study.…”
Section: Discussioncontrasting
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“…No entanto, há evidências de que o extrato hidroalcoólico do farelo da casca de pequi (C. brasiliense), quando administrado via intraperitoneal em camundongos, causa uma toxicidade igual a 0,31mg/mL (CL 50 ). (ALMEIDA et al, 2010).…”
Section: Toxicidadeunclassified
“…Os óleos essenciais vêm sendo investigados, partindo da possibilidade de utilizá-los como produtos alternativos, com menor potencial tóxico, para aplicação na saúde humana e animal (Almeida et al 2010).…”
Section: Introductionunclassified