Thyroid and celiac disease: clinical, serological, and echographic study

Velluzzi, Fernanda; Caradonna, A; Boy, M. F.; Pinna, Ma; Cabula, R; Lai, Michela; Piras, Enrico Maria; Corda, G; Mossa, P; Atzeni, Francesco; Loviselli, Andrea; Usai, Paolo; Mariotti, Stefano

doi:10.1016/s0002-9270(98)00172-5

Cited by 30 publications

(24 citation statements)

References 19 publications

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“…Most of the patients with CD were suffering from HT, but there was no significant statistical relation between CD and HT; however, in Hadithi et al study, there is relation between HT and CD [5], summarized prevalence of CD in hypothyroid patients in some studies (Table 3) [12–18]. Conversely, there is also an increased prevalence of immune-based disorders among patients with CD (Table 4) [5, 7–9, 19–21]. Female sex predominance was seen patients with celiac, but it was not significant ( P = 0.626), however other reports show female sex predominance role in this disease [28].…”

Section: Discussionmentioning

confidence: 99%

“…Hashimotos thyroiditis (HT) is defined by the presence of high serum thyroid antibody concentrations (TG and/or TPO) [5]. Likewise, several studies reported prevalence's ranging from 10% to 30% [6–9] for autoimmune thyroid disease, and from 4 to 19% for HT in patients with CD [7–10]. Screening patients with autoimmune thyroid disease for CD and vice versa can give an accurate perception to this association [1].…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Celiac Disease in Patients with Hypothyroidism

Mehrdad

Mansour-Ghanaei

Mohammadi

et al. 2012

Journal of Thyroid Research

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Background. Celiac disease (CD) is closely associated with other autoimmune endocrine disorders, particularly autoimmune thyroid disease. The aim of this study was to find the frequency of celiac disease in patients with hypothyroidism in Guilan province, north of Iran. Methods. A total of 454 consecutive patients with hypothyroidism underwent celiac serological tests antiGliadin antibodies (AGA), antitissue transglutaminase antibodies (IgA-tTG) and antiendomysial antibodies (EMA-IgA). Small intestinal biopsy was performed when any of celiac serological tests was positive. Results. Eleven (2.4%) patients were positive for celiac serology, and two patients with documented villous atrophy were diagnosed with classic CD (0.4%; 95%). Two patients with classic CD had Hashimoto's thyroiditis (HT) (0.6%; 95%). Six (54.5%) of 11 were suffering from overt hypothyroidism and 45.5% from subclinical hypothyroidism. Six (54.5%) had HT, and 45.5% had nonautoimmune hypothyroidism. Conclusions. In this study, prevalence of CD was lower than other studies. Most of the patients with CD were suffering from HT, but there was no significant statistical relation between CD and HT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frequency of Celiac Disease in Patients with Hypothyroidism

Mehrdad

Mansour-Ghanaei

Mohammadi

et al. 2012

Journal of Thyroid Research

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“…As in the former studies that investigated DH patients, we also found increased values of thyroid antibodies and a higher prevalence of thyroid disease in females than in males. To our knowledge there is only one recently published paper evaluating thyroid disorders in coeliac patients by sonography [16]. Prospective studies investigating thyroid disorders in patients with coeliac disease are rare.…”

Section: Discussionmentioning

confidence: 99%

Dermatitis herpetiformis is associated with atrophic but not with goitrous variant of Hashimoto's thyroiditis

Zettinig

Weissel

Flores

et al. 2000

Eur J Clin Investigation

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“…3 Also, it is known that, in celiac disease, there is an increased frequency of endocrinological diseases of autoimmune etiology. Among these, in patients with autoimmune thyroiditis (Hashimoto’s thyroiditis, Graves’ disease), type I diabetes mellitus and Addison’s disease, the frequency of celiac disease is much higher than in the normal population 4–8. It is known that the above-mentioned association is important in terms of disease treatment.…”

Section: Introductionmentioning

confidence: 99%

Autoantibody Frequency in Celiac Disease

Çağlar

Uğurlu

Özenoğlu

et al. 2009

Clinics

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AIM:In our study, we investigated the levels of glutamic acid decarboxylase antibody (anti-GAD), islet cell antibody (ICA), thyroperoxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), antinuclear antibodies (FANA), antibodies to double-stranded DNA (anti-ds DNA), antibody to Sjögren syndrome A antigen (anti-SSA), antibody to Sjögren syndrome B antigen (anti-SSB), Smith antibody (anti-Sm), smooth muscle antibodies (ASMA), and antimitochondrial antibody liver-kidney microsome (AMA-LKM) in patients with celiac disease as compared to healthy controls and autoimmune hypothyroid patients.MATERIALS AND METHODS:A total of 31 patients with celiac disease, 34 patients with autoimmune hypothyroidism and 29 healthy subjects were included in this study. Anti-SSA, anti-SSB, anti-Sm, anti-ds DNA, anti-GAD, anti-TPO and anti-TG were studied by Enzyme-Linked Immunosorbent Assay (ELISA), and AMA-LKM, ASMA, ANA and ICA were studied by immunofluorescence. Clinical data and the results of free thyroxine-thyroid stimulating hormone (FT4-TSH) were collected from the patients’ files by retrospective analysis. SPSS ver 13.0 was used for data analysis, and the χ2 method was used for comparisons within groups.RESULTS:The frequency of anti-SSA, anti-SSB, anti-GAD, anti-Sm, anti-ds DNA, AMA-LKM, ASMA, ANA and ICA were not significantly different between the groups. Levels of anti-TPO and anti-TG antibodies were found to be significantly higher (<0.001) in autoimmune hypothyroid patients when compared with other groups.CONCLUSION:In previous studies, an increased frequency of autoimmune diseases of other systems has been reported in patients with celiac disease. We found that the frequency of autoimmune antibodies specific for other autoimmune diseases was not higher in celiac disease.

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Thyroid and celiac disease: clinical, serological, and echographic study

Abstract: An elevated prevalence of clinical and subclinical autoimmune thyroid autoimmunity was found in Sardinian celiac patients, especially in those displaying the DQB1*0502 genotype; this finding could be related to a particular genetic background of the Sardinian population.

Cited by 30 publications

References 19 publications

Frequency of Celiac Disease in Patients with Hypothyroidism

Frequency of Celiac Disease in Patients with Hypothyroidism

Dermatitis herpetiformis is associated with atrophic but not with goitrous variant of Hashimoto's thyroiditis

Autoantibody Frequency in Celiac Disease

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