Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview

Gholizadeh, Omid; Yasamineh, Saman; Amini, Parya; Afkhami, Hamed; Delarampour, Abbasali; Akbarzadeh, Sama; Matloub, Rasool Karimi; Zahedi, Mahlagha; Hosseini, Parastoo; Hajiesmaeili, Mehrnaz; Poortahmasebi, Vahdat

doi:10.1186/s12985-022-01935-7

Cited by 16 publications

(4 citation statements)

References 207 publications

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“…Antigen conveyance as vaccination is ideal for inorganic NPs because of their tiny size, improved constancy, controlled adjustability, higher penetrance, superior drug loadings, and triggered release profile. These cutting-edge developments, known as hybrid inorganic NPs, often have an inorganic core surrounded by an organic shell (Gholizadeh et al 2022 ; Yasamineh et al 2022a , b ). Among these methods, NPs, which generally range in size from 0.2 to 100 nm, performed well as new antimicrobial substances (Panáček et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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Bismuth (Bi) combinations have been utilized for the treatment of bacterial infections. In addition, these metal compounds are most frequently utilized for treating gastrointestinal diseases. Usually, Bi is found as bismuthinite (Bi sulfide), bismite (Bi oxide), and bismuthite (Bi carbonate). Newly, Bi nanoparticles (BiNP) were produced for CT imaging or photothermal treatment and nanocarriers for medicine transfer. Further benefits, such as increased biocompatibility and specific surface area, are also seen in regular-size BiNPs. Low toxicity and ecologically favorable attributes have generated interest in BiNPs for biomedical approaches. Moreover, BiNPs offer an option for treating multidrug-resistant (MDR) bacteria because they communicate directly with the bacterial cell wall, induce adaptive and inherent immune reactions, generate reactive oxygen compounds, limit biofilm production, and stimulate intracellular impacts. In addition, BiNPs in amalgamation with X-ray therapy as well as have the capability to treat MDR bacteria. BiNPs as photothermal agents can realize the actual antibacterial through continuous efforts of investigators in the near future. In this article, we summarized the properties of BiNPs, and different preparation methods, also reviewed the latest advances in the BiNPs’ performance and their therapeutic effects on various bacterial infections, such as Helicobacter pylori , Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli . Graphical abstract: BiNPs are antibacterial and ideal photothermal agents to inhibit various bacterial infections

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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“…The MNP-based rapid ELISAs are rapid and easy to perform, and the assays could be easily adapted to a high throughput format for screening patients or for the development of new vaccines. In addition to ELISAs, these nanoparticles offer versatile applications, including surface deployment on items like masks or as a sterilization spray to sequester viral particles effectively . Furthermore, the precision of MNPs allows for the specific targeting of treatments to particular cells or regions within the body.…”

Section: Resultsmentioning

confidence: 99%

A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Vishweshwaraiah,

Hnath,

Wang

et al. 2024

ACS Appl. Bio Mater.

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As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues its global spread, the exploration of novel therapeutic and diagnostic strategies is still needed. The virus enters host cells by binding the angiotensin-converting enzyme 2 (ACE2) receptor through the spike protein. Here, we develop an engineered, small, stable, and catalytically inactive version of ACE2, termed miniature ACE2 (mACE2), designed to bind the spike protein with high affinity. Employing a magnetic nanoparticlebased assay, we harnessed the strong binding affinity of mACE2 to develop a sensitive and specific platform for the detection or neutralization of SARS-CoV-2. Our findings highlight the potential of engineered mACE2 as a valuable tool in the fight against SARS-CoV-2. The success of developing such a small reagent based on a piecewise molecular design serves as a proof-of-concept approach for the rapid deployment of such agents to diagnose and fight other viral diseases.

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“…Nanoparticles are part of therapeutic, diagnostic, and preventive methods to control viral infections. Consequently, prophylactic agents, early detection, and treatment of viral infection by nanoparticles in HSCT recipients are critical [ 92 – 95 ]. In addition, gene therapy for viral infections using HSC can prevent several stages of viral infections.…”

Section: Viewpoints and Landscapementioning

confidence: 99%

Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects

Nasiri

Mohammadzadehsaliani²,

Kheradjoo³

et al. 2023

Cell Commun Signal

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Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and preserve a functional hematopoietic system in long-term periods after transplantation into conditioned hosts. HSCs are thus crucial cellular targets for the continual repair of inherited hematologic, metabolic, and immunologic disorders. In addition, HSCs can undergo various fates, such as apoptosis, quiescence, migration, differentiation, and self-renewal. Viruses continuously pose a remarkable health risk and request an appropriate, balanced reaction from our immune system, which as well as affects the bone marrow (BM). Therefore, disruption of the hematopoietic system due to viral infection is essential. In addition, patients for whom the risk-to-benefit ratio of HSC transplantation (HSCT) is acceptable have seen an increase in the use of HSCT in recent years. Hematopoietic suppression, BM failure, and HSC exhaustion are all linked to chronic viral infections. Virus infections continue to be a leading cause of morbidity and mortality in HSCT recipients, despite recent advancements in the field. Furthermore, whereas COVID-19 manifests initially as an infection of the respiratory tract, it is now understood to be a systemic illness that significantly impacts the hematological system. Patients with advanced COVID-19 often have thrombocytopenia and blood hypercoagulability. In the era of COVID-19, Hematological manifestations of COVID-19 (i.e., thrombocytopenia and lymphopenia), the immune response, and HSCT may all be affected by the SARS-CoV-2 virus in various ways. Therefore, it is important to determine whether exposure to viral infections may affect HSCs used for HSCT, as this, in turn, may affect engraftment efficiency. In this article, we reviewed the features of HSCs, and the effects of viral infections on HSCs and HSCT, such as SARS-CoV-2, HIV, cytomegalovirus, Epstein-Barr virus, HIV, etc.

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Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview

Cited by 16 publications

References 207 publications

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects

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