The role of social experience in the production of gastric ulcers in hooded rats placed in a conflict situation.

Conger, John J.; Sawrey, William L.; Turrell, Eugene S.

doi:10.1037/h0041533

Cited by 62 publications

(20 citation statements)

References 18 publications

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“…Similarly, in both monogamous prairie voles as well as non-human primates, stress responses (corticosterone/cortisol) to a novel environment were reduced when accompanied by a con-specific (30,31). Linking the presence of familiar others with health-related outcomes, the efficacy with which unexpected electric shock led to peptic ulcers in rats was shown to be due, in large part, to whether the rats were shocked in isolation (high ulcer rates) or in the presence of littermates (low ulcer rates) (32). Moreover, social crowding led to hypertension in mice, but only when mice were placed with strangers, not when they were placed with littermates (33).…”

Section: Receiving or Perceiving Social Supportmentioning

confidence: 99%

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

Eisenberger

2013

Psychosomatic Medicine

161

117

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Decades of research have demonstrated strong links between social ties and health. Although considerable evidence has shown that social support can attenuate downstream physiological stress responses that are relevant to health, the neurocognitive mechanisms that translate perceptions of social ties into altered physiological responses are still not fully understood. This review integrates research from social and affective neuroscience to illuminate some of the neural mechanisms involved in social support processes, which may further our understanding of the ways in which social support influence health. This review focuses on two types of social support that have been shown to relate to health: receiving and giving social support. As the neural basis of receiving support, this article reviews the hypothesis that receiving support may benefit health through the activation of neural regions that respond to safety and inhibit threat-related neural and physiological responding. This article will then review neuroimaging studies in which subjects were primed with or received support during a negative experience as well as studies in which self-reports of perceived support were correlated with neural responses to a negative experience. As the neural basis of giving support, this article reviews the hypothesis that neural regions involved in maternal caregiving behavior may be critical for the health benefits of support-giving through the inhibition of threat-related neural and physiological responding. Neuroimaging studies in which subjects provided support to others or engaged in other related forms of prosocial behavior will then be reviewed. Implications of these findings for furthering our understanding of the relationships between social support and health are discussed.

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Section: Receiving or Perceiving Social Supportmentioning

confidence: 99%

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

Eisenberger

2013

Psychosomatic Medicine

161

117

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“…One manifestation of this is the organism's characteristic response to separation as a physiologic stressor 42–44 and social bonding as its salutary antithesis 45,46 . In nonhuman social animals these effects occur whether the bonds are those of a sexual pair, 41 parent‐offspring, 47 littermates, 48,49 or social companions 32 . Evidence from the experience of humans with separation and reunion suggests that we experience similar physiologic interdependence 50,51 .…”

Section: The Sociophysiology Of Relationshipsmentioning

confidence: 99%

The sociophysiology of caring in the doctor-patient relationship

Adler

2002

J Gen Intern Med

122

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The emotional investment required to construct a caring doctor‐patient relationship can be justified on humane grounds. Can it also be justified as a direct physiologic intervention? Two lines of evidence point in this direction. People in an empathic relationship exhibit a correlation of indicators of autonomic activity. This occurs between speakers and responsive listeners, members of a coherent group, and bonded pairs of higher social animals. Furthermore, the experience of feeling cared about in a relationship reduces the secretion of stress hormones and shifts the neuroendocrine system toward homeostasis. Because the social engagement of emotions is simultaneously the social engagement of the physiologic substrate of those emotions, the process has been labeled sociophysiology. This process can influence the health of both parties in the doctor‐patient relationship, and may be relevant to third parties.

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“…Furthermore, the susceptibility to such ulcers appears to be influenced by such variables as the social interactions among these animals. 3 Bonfils and his associates 2 ' a have produced gastric ulcers in a high percentage of Wistar rats following approximately 20 hours of physical immobilization together with food and water deprivation. The lesions resulting from this procedure were located in the body of the stomach, which is the glandular, acid-secreting, lower portion.…”

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confidence: 98%

Blood Pepsinogen and Gastric Erosions in the Rat

Ader¹,

Beels²,

Tatum³

1960

Psychosomatic Medicine

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I N RECENT YEARS much attention has been given to the problem of predicting those who will eventually manifest psychosomatic disorders. With regard to duodenal ulcers, attention has been focused on blood pepsinogen or uropepsin levels as predictors of susceptibility. In a recent review, Mirsky 8 points out that the rate of excretion of pepsinogen in the urine and the concentration of pepsinogen in the blood plasma or serum of patients with duodenal ulcers are greater than those of subjects without gas-

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The role of social experience in the production of gastric ulcers in hooded rats placed in a conflict situation.

Cited by 62 publications

References 18 publications

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

The sociophysiology of caring in the doctor-patient relationship

Blood Pepsinogen and Gastric Erosions in the Rat

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