The emotional investment required to construct a caring doctor‐patient relationship can be justified on humane grounds. Can it also be justified as a direct physiologic intervention? Two lines of evidence point in this direction. People in an empathic relationship exhibit a correlation of indicators of autonomic activity. This occurs between speakers and responsive listeners, members of a coherent group, and bonded pairs of higher social animals. Furthermore, the experience of feeling cared about in a relationship reduces the secretion of stress hormones and shifts the neuroendocrine system toward homeostasis. Because the social engagement of emotions is simultaneously the social engagement of the physiologic substrate of those emotions, the process has been labeled sociophysiology. This process can influence the health of both parties in the doctor‐patient relationship, and may be relevant to third parties.

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"Talking" therapy is examined as an interpersonal transaction. The personal-experience narrative is used as a vehicle through which the patient and therapist coprocess a mutual experience. Within the narrative transaction, the patient is able to vicariously re-experience and reconfigure the narrated events as he/she believes the therapist is experiencing them. Nonverbal symbolic modes of communication such as music, movement, and art also provide media through which patients and therapists can coprocess a mutual experience. The vicarious coprocessing of experience is a therapeutic factor common to talking therapy, music therapy, art therapy, movement therapy, conventional social interaction, and some healing practices in other cultures.

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