The Role of Rice Hull Liquid Smoke in the Traumatic Ulcer Healing

Arundina, Ira; Diyatri, Indeswati; Kusumaningsih, Tuti; Surboyo, Meircurius Dwi Condro; Monica, Elita; Afanda, Novitasari Mira

doi:10.1055/s-0040-1714445

Cited by 10 publications

(20 citation statements)

References 35 publications

(50 reference statements)

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“…LR-HS contains phenolic compounds that have anti-inflammatory effects 15 , 16 , 17 given that they down-regulate tumour necrosis factor α (TNF-α) expression 17 and have thus been proven capable of accelerating the inflammatory process. 18 Since TNF-α is a cytokine that induces the inhibitor of nuclear factor-κB (IκB) kinase (IKK) activity, the degradation of I-kB, and activates NF-kB, the down-regulation of TNF-α results in NF-kB inhibition. 15 , 16 This prompts a switch from classically-activated macrophages (M1) to alternatively-activated macrophages (M2).…”

Section: Introductionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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Objective The healing process of a traumatic ulcer requires growth factors to rebuild the lost tissue after the inflammatory process has been completed. Liquid rice hull smoke (LR-HS) has shown unique anti-inflammatory properties. This study analyses the role of LR-HS in growth factor stimulation for the healing of traumatic ulcers, such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and collagen type 1 (COL-1) expression. Methods We obtained LR-HS from the pyrolysis of rice hulls. Traumatic ulcers were created in the labial fornix incisive inferior of Wistar rats and treated with LR-HS once a day for 3, 5, and 7 days. The control group was treated with sterile water. Each animal was sacrificed after treatment, and its labial fornix incisive inferior tissues were biopsied and immunohistochemically stained to examine FGF, VEGF, PDGF, and COL-1 expression. Result The treatment of traumatic ulcers with LR-HS showed an increase in FGF, VEGF, PDGF, and COL-1 expression. VEGF expression increased under LR-HS treatment compared with the control 7-day treatment groups ( p < 0.000). FGF and COL-1 expression increased under LR-HS treatment compared with the control 5- and 7-day treatment groups ( p < 0.000). PDGF expression increased after treatment with LR-HS for 3, 5, and 7 days ( p < 0.000). Conclusion This study has demonstrated that LR-HS can induce the expression of growth factors during the healing of a traumatic ulcer using immunohistochemical staining. We suggest that LR-HS can be used as a herbal medicine for oral ulcer therapy.

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Section: Introductionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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“…The use of liquid smoke in this study was based on previous research. 11 14 Liquid smoke is obtained from rice husks through the pyrolysis process, with a combustion temperature of 400°C over 8 hours. The smoke is then condensed using a condenser, then submitted to the distillation process performed using a temperature of 120 to 150°C.…”

Section: Methodsmentioning

confidence: 99%

“…The smoke is then condensed using a condenser, then submitted to the distillation process performed using a temperature of 120 to 150°C. 14 …”

Section: Methodsmentioning

confidence: 99%

“…11,12 This liquid smoke has shown a low toxicity 11,12 and a potential to be beneficial to human health. 13 Furthermore, rice husk liquid smoke has shown efficiency in the inflammatory process of oral wound healing through the increased recruitment of inflammatory cells and decreased recruitment of proinflammatory cytokines and inflammatory mediators, such as the tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), IL-6, prostaglandin E, and leukotriene B4 (LTB4), 14,15 by inhibiting reactive oxygen species (ROS) 16 and nitric oxide. 15 One of the oral diseases caused by bacteria is periodontitis.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Rice Husk Liquid Smoke in Porphyromonas gingivalis-Induced Periodontitis

et al. 2021

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Objectives The purpose of this study is to analyze the effects of rice husk liquid smoke in Porphyromonas gingivalis-induced periodontitis in the inflammatory and proliferation marker such as nuclear factor kappa β (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β), fibroblast growth factor 2 (FGF2), collagen type 1 (COL-1) expression, and the number of macrophages, lymphocytes, and fibroblasts. Materials and Methods Rice husk liquid smoke is obtained by the pyrolysis process. Porphyromonas gingivalis-induced periodontitis in 20 μL phosphate-buffered saline containing 1 × 109 CFU was injected into the lower anterior gingival sulcus of Wistar rats. The periodontitis was then treated with 20 μL/20 g body weight of rice husk liquid smoke once a day for 2 and 7 days, respectively. After treatment, the bone and lower anterior gingival sulcus were analyzed with immunohistochemistry and hematoxylin–eosin staining. Results The treatment of periodontitis with rice husk liquid smoke showed a lower NF-kB, TNF-α, and IL-6 expression and a higher TGF-β, FGF2, and COL-1 expression than the control after treatment for 2 and 7 days (p < 0.05), respectively. The number of macrophages and fibroblasts was also higher when compared with the control group (p < 0.05), but the number of lymphocytes was lower than the control (p < 0.05). Conclusion Rice husk liquid smoke showed its effects on Porphyromonas gingivalis-induced periodontitis with a decrease in inflammatory markers and an increase in proliferation markers. The development of a rice husk liquid smoke periodontitis treatment is promising.

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“…The treatment of traumatic ulcers is usually performed through the administration of antiseptics, antibiotics, and steroids. However, antibiotics and steroids that are used for a long time can cause resistance and unpleasant side effects [5,6]. This led to the use of other alternative treatments, such as the use of probiotics.…”

Section: Introductionmentioning

confidence: 99%

The differences in the number of fibroblasts and blood vessels after the topical and systemic administration of Lactobacillus casei Shirota probiotics for the treatment of traumatic ulcers in Wistar rats (Rattus norvegicus)

et al. 2021

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Background and Aim: The use of drugs as a therapy for traumatic ulcers may lead to drug resistance and other side effects. Lactobacillus casei Shirota can affect the number of fibroblasts and blood vessels in wound healing. The aim of this study was to investigate the difference in the number of fibroblast cells and blood vessels after the topical and systemic administration of L. casei Shirota probiotics in Wistar rats with traumatic ulcer. Materials and Methods: Overall, 36 healthy male Wistar rats aged 2-3 months old and weighing 175-250 g in body weight were used as a sample. Traumatic ulcer was made on the labial fornix incisive inferior. The subject rats were divided into groups: (1) A control group over 3 days, (2) a group that used distilled water over 7 days, (3) a group that underwent topical treatment over 3 days, (4) a group that used probiotics administered topically over 7 days, (5) a group that underwent systemic treatment over 3 days, and (6) a group that took oral probiotics for the traumatic ulcers over 7 days. The number of fibroblasts and blood vessels was observed through a hematoxylin-eosin examination. Results: Based on the results of the study, a significant difference was observed in the number of fibroblasts (p=0.00) and blood vessels (p=0.018) in the 3-day topical group that underwent a 3-day systemic administration of probiotics compared with the number of fibroblast cells in the 7-day topical group and 7-day systemic group (p=0.00). Conclusion: Overall, significant differences were observed in the number of fibroblasts and blood vessels in Wistar rats with traumatic ulcer after undergoing the topical and systemic administration of L. casei Shirota probiotics.

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The Role of Rice Hull Liquid Smoke in the Traumatic Ulcer Healing

Cited by 10 publications

References 35 publications

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

The Effects of Rice Husk Liquid Smoke in Porphyromonas gingivalis-Induced Periodontitis

The differences in the number of fibroblasts and blood vessels after the topical and systemic administration of Lactobacillus casei Shirota probiotics for the treatment of traumatic ulcers in Wistar rats (Rattus norvegicus)

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