Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina, Ira; Diyatri, Indeswati; Surboyo, Meircurius Dwi Condro; Monica, Elita; Afanda, Novitasari Mira

doi:10.1016/j.jtumed.2021.01.003

Cited by 11 publications

(19 citation statements)

References 47 publications

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“…Table 2 shows the characteristics of the rats used in the articles reviewed. There are two types of rats used in these studies related to oral mucosal ulcer models: Wistar rats in 8 articles [15,16,18,19,22,24,27,28] and Sprague-Dawley rats in 6 articles [17,20,21,23,25,26]. The number of rat samples used varied in each article, but most articles (10 articles) did not mention the method of determining the number, while others mentioned using Animal Research Guidelines: Reporting In vivo Experiments (ARRIVE) in 2 articles and using Lemeshow's formula in 2 articles [19,23,26,28].…”

Section: Resultsmentioning

confidence: 99%

Oral Mucosal Ulcer Induction Methods in Rats: A Systematic Review

ERIS NURUL RAHMADHINI,

WAHYUNI

2023

Int J App Pharm

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Oral mucosal ulcers are a prevalent condition, but there are still limited drugs available to treat them. Varieties of induction techniques to obtain oral mucosal ulcer models in rats have frequently been used. This systematic review aimed to describe different approaches and to recommend the most effective method for oral mucosal ulcer induction methods in rats for anti-oral mucosal ulcer drug discovery. The PRISMA guidelines were used in the framework regarding this systematic review. The electronic databases PubMed, Science Direct, SCOPUS, and EBSCOhost-CINAHL Plus were used for article searching using specific keywords. The Risk of Bias Tool from Syrcle was used to undertake the evaluation of bias risk. Based on the analysis of 14 articles, the following findings were gathered: Wistar rats were frequently used mouse strains at an average of 8 w old and weighed between 120 and 300 g. Induction methods used to obtain ulcer models were acetic acid, biopsy punch, scalpel blade, thermal, and phenol. Acetic acid induction was the most commonly used compared to the other induction techniques. The ulcers were obtained by acetic acid identical to those that occur on the human oral mucosa and available at a reasonable price. However, the ulcer formation takes longer compared with biopsy punch and scalpel blade induction. The systematic review found that there are various methods for inducing oral ulcers in rats, with acetic acid being the recommended method to produce a suitable mucosal ulcer model in rats.

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Section: Resultsmentioning

confidence: 99%

Oral Mucosal Ulcer Induction Methods in Rats: A Systematic Review

ERIS NURUL RAHMADHINI,

WAHYUNI

2023

Int J App Pharm

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“…Topical administration of liquid smoke increased the expression of FGF-2 compared to fiveand seven-day administration of a control (Arundina et al, 2021b).…”

Section: Increased Fgf-2 Expressionmentioning

confidence: 87%

“…In addition, growth factor expression and collagen formation are also positive in the administration of liquid smoke from rice husk. The topical administration of liquid smoke from rice husk shows higher TGFβ, FGF-2, VEGF, PDGF and COL-1 expression (Arundina et al, 2021b). The mechanism that might be involved uses anti-inflammatory effects that Inhibit NF-B and TNF-, resulting in more dominant M2 polarisation through a switch from M1 to M2.…”

Section: Discussionmentioning

confidence: 99%

The potential of liquid smoke as an oral ulcer remedies: A proposed mechanism based on systematic review

Surboyo¹,

Ernawati²,

Arundina³

et al. 2021

J Pharm Pharmacogn Res

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Context: The standard management of oral ulcer therapy is focused only on symptomatic therapy, such as reducing pain. To date, there is no topical drug that has the pharmacodynamics to intervene in oral ulcer pathogenicity. Liquid smoke is traditionally used as a safe natural preservative. The liquid smoke is highly phenolic and compound rich. It is presumed to have analgesic and anti-inflammatory effects with potentially promising therapeutic effects on oral ulcers. Aims: To describe the possible pharmacodynamics or action mechanism of liquid smoke as a promising remedy for oral ulcer therapy. Methods: A comprehensive literature review on PubMed, ScienceDirect, Scopus and Embase was performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The keywords used included ‘liquid smoke’, ‘wood vinegar’, ‘liquid pyrolysis’ and ‘oral ulcer’. A screening process, including titles, abstracts and full texts, was performed. Eight related articles were selected to describe the possible pharmacodynamics or mechanism action of the liquid smoke originating from coconut shells and rice hulls for oral ulcer remedies. Results: Liquid smoke from coconut shell and rice husk is highly contained phenol, guaiacol and 2-methoxy-5-methylphenol (2-EMP). These compounds are antioxidants that can bind reactive oxygen species and increase cellular responses, inhibiting nuclear factor-kappa B activation and pro-inflammatory cytokine production while increasing macrophage differentiation to M2. The increase of M2, with help from lymphocytes, can secrete various growth factors, which can accelerate the proliferation of fibroblasts and collagens needed in the healing process of oral ulcers. Conclusions: Liquid smoke pharmacodynamics inhibit both inflammatory and proliferation pathway stimulation, which promises remedies for oral ulcers.

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“…4 Several ingredients in Indonesia that can be used to produce liquid smoke include rice husks, 5 coconut shells, 6 7 durian, 8 lamtoro, corn comb, 9 bamboo, 10 and cocoa bean skin. 11 Of these various types of materials, rice husks have been shown to have the potential to treat various diseases, including periodontitis, 12 oral ulcer, 13 14 15 16 diabetes, 17 18 and burn. 19 The liquid smoke rice hull contains phenol, 2-methoxy-phenol, mequinol, 6-octadecenoic acid, oleic acid, and 9-octadecenoic acid 5 that possess the analgesic, 20 anti-inflammation, 14 antibacterial, 12 21 and lower toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…11 Of these various types of materials, rice husks have been shown to have the potential to treat various diseases, including periodontitis, 12 oral ulcer, 13 14 15 16 diabetes, 17 18 and burn. 19 The liquid smoke rice hull contains phenol, 2-methoxy-phenol, mequinol, 6-octadecenoic acid, oleic acid, and 9-octadecenoic acid 5 that possess the analgesic, 20 anti-inflammation, 14 antibacterial, 12 21 and lower toxicity. 5 22 The liquid smoked rice husk is widely used by Indonesian as natural preservative for fish 23 24 and meat.…”

Section: Introductionmentioning

confidence: 99%

In Silico Study of Liquid Smoke Rice Husk against COVID-19

Arundina

Frimayanti²,

Surboyo

et al. 2022

Eur J Dent

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Objectives Liquid smoke rice husk has been researched and proved to consist of antibacterial, analgesic, anti-inflammatory, and growth factor stimulatory properties. By these complex properties, the liquid smoke rice hull is able to purpose as a novel coronavirus disease 2019 (COVID-19) inhibitor. The research was conducted to analyze the role of the dominant compound in rice husk liquid smoke against one of the main proteases in complex with inhibitor N3 of COVID-19 and 6LU7 protein data bank (PDB) ID. Material and Methods The Molecular Operating Environment (MOE) 2020.0901 (Chemical computing group) was used to analyzed the interaction. The molecular structure test, including phenol, mequinol, 2-methoxy-phenol, 6-octadecenoic acid, oleic acid, 9-cctadecenoic acid, was chosen. The lopinavir as positive control and 6LU7 as COVID-19 protein were chosen. All the protein analyses were conducted using docking molecular. Result The phenol, 2-methoxy-phenol, mequinol and 9-octadecenoic acid have higher binding free energy that causes difficult to bind to the active site of protein 6LU7 (−3.4758, −3.5509, −3.6845, and −5.0173 kcal/mol, respectively). The minor component of liquid smoke, such as 6-octadecenoic acid and oleic acid, has the binding free energy (−5,5327 and −5,4208 kcal/mol) and more factor of binding presumably as active COVID-19 inhibitor. Conclusion The liquid smoke rice husk has active component like 6-octadecenoic acid and oleic acid are presumably as active COVID-19 inhibitor.

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Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Cited by 11 publications

References 47 publications

Oral Mucosal Ulcer Induction Methods in Rats: A Systematic Review

Oral Mucosal Ulcer Induction Methods in Rats: A Systematic Review

The potential of liquid smoke as an oral ulcer remedies: A proposed mechanism based on systematic review

In Silico Study of Liquid Smoke Rice Husk against COVID-19

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