The role of cohabitant unusual bacterial species in infection of cardiovascular implantable electronic devices (CIED)

Pichlmaier, Maximilian; Knigina, Ludmilla; Kuehn, C.; Khaladj, Nawid; Oswald, Hanno; Klein, Gunnar; Haverich, Axel; Abraham, Wolf‐Rainer

doi:10.3233/thc-120711

Cited by 5 publications

(8 citation statements)

References 26 publications

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“…The major bacterium was coagulase-negative Staphylococcus . The high positive results were in line with previous studies [ 9 , 12 , 23 ]. Compared with the relative lower culture positive rate (18.6%), DNA was isolated from 29.7% of biofilms on the generator surface and 22.0% of subcutaneous pocket tissues, and 15.3% from both.…”

Section: Discussionsupporting

confidence: 92%

“…Bacterial biofilms and bacterial colonization on the surface of in vivo implanted devices might lead to clinical infection[ 5 – 8 ]. Recent researches revealed that asymptomatic bacterial colonization on PMs might be ubiquitous and increase the risk of clinical PM infection[ 9 – 12 ]. Early diagnosis of patients with asymptomatic bacterial colonization is an important basis for applying specific preventive measures and reducing clinical PM infection.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Bacteriology and Risk Factor Analysis of Asymptomatic Bacterial Colonization in Pacemaker Replacement Patients

Chu

Sun

et al. 2015

PLoS ONE

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BackgroundRecent researches revealed that asymptomatic bacterial colonization on PMs might be ubiquitous and increase the risk of clinical PM infection. Early diagnosis of patients with asymptomatic bacterial colonization could provide opportunity for targeted preventive measures.ObjectiveThe present study explores the incidence of bacterial colonization of generator pockets in pacemaker replacement patients without signs of infection, and to analyze risk factors for asymptomatic bacterial colonization.MethodsFrom June 2011 to December 2013, 118 patients underwent pacemaker replacement or upgrade. Identification of bacteria was carried out by bacterial culture and 16S rRNA sequencing. Clinical risk characteristics were analyzed.ResultsThe total bacterial positive rate was 37.3% (44 cases), and the coagulase-negative Staphylococcus aureus detection rate was the highest. Twenty two (18.6%) patients had positive bacterial culture results, of which 50% had coagulase-negative staphylococcus. The bacterial DNA detection rate was 36.4 % (43 cases). Positive bacterial DNA results from pocket tissues and the surface of the devices were 22.0% and 29.7%, respectively. During follow-up (median, 27.0 months), three patients (6.8%, 3/44) became symptomatic with the same genus of microorganism, S. aureus (n=2) and S. epidermidis (n=1). Multivariable logistic regression analysis showed that history of bacterial infection, use of antibiotics, application of antiplatelet drugs, replacement frequency were independent risk factors for asymptomatic bacterial colonization.ConclusionThere was a high incidence of asymptomatic bacterial colonization in pacemaker patients with independent risk factors. Bacterial culture combined genetic testing could improve the detection rate.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Identification of Bacteriology and Risk Factor Analysis of Asymptomatic Bacterial Colonization in Pacemaker Replacement Patients

Chu

Sun

et al. 2015

PLoS ONE

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“…The major bacterium was coagulase-negative Staphylococcus (11.5%). The high positive results were consistent with previous studies and suggested that similar ubiquitous bacterial colonization was present [ 9 , 12 , 23 ]. Research indicated that one-third of implantable cardioverter-defibrillator (ICD) patients were positive for microbial swab culture in pocket tissues and drawn wires when replacing generator and wires [ 10 ].…”

Section: Discussionsupporting

confidence: 92%

“…When the balance is broken, bacteria are destroyed or infection occurs. Many factors may influence this balance, such as the number of bacteria or the addition of a new infection, the virulence of bacteria and their ability to adapt to the unfavourable environment, and the defensive capacity of the host [ 9 – 12 ]. Repeating interventional treatments decreased patients' defense to pathogens [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial biofilms and bacterial colonization on the surface of implanted devices in vivo might lead to clinical infection [ 5 – 8 ]. Recent research revealed that asymptomatic bacterial colonization on CIEDs might be ubiquitous and increase the risk of clinical CIED infection [ 9 – 12 ]. Early diagnosis of patients with asymptomatic bacterial colonization is an important basis to apply specific preventative measures and to reduce clinical CIED infection.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices

Chu

et al. 2014

BioMed Research International

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Asymptomatic bacterial colonization of cardiovascular implantable electronic devices (CIEDs) is widespread and increases the risk of clinical CIED infection. The aim of the study was to evaluate the incidence of bacterial colonization of generator pockets in patients without signs of infection and to analyze the relationship with clinical infection and risk factors. From June 2011 to December 2012, 78 patients underwent CIED replacement or upgrade. Exclusion criteria included a clinical diagnosis of CIED infection, bacteremia, or infective endocarditis. All patients were examined for evidence of bacterial 16S rDNA on the device and in the surrounding tissues. Infection cases were recorded during follow-up. The bacterial-positive rate was 38.5% (30 cases); the coagulase-negative Staphylococcus detection rate was the highest (9 cases, 11.5%). Positive bacterial DNA results were obtained from pocket tissue in 23.1% of patients (18 cases), and bacterial DNA was detected on the device in 29.5% of patients (23 cases). During follow-up (median 24.6 months), two patients (6.7%, 2/30) became symptomatic with the same species of microorganism, S. aureus and S. epidermidis. Multivariable logistic regression analysis found that the history of bacterial infection, use of antibiotics, application of antiplatelet drugs, replacement frequency, and renal insufficiency were independent risk factors for asymptomatic bacterial colonization.

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Implant Related Infections

Abraham

2014

Biomedical Technology

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The role of cohabitant unusual bacterial species in infection of cardiovascular implantable electronic devices (CIED)

Cited by 5 publications

References 26 publications

Identification of Bacteriology and Risk Factor Analysis of Asymptomatic Bacterial Colonization in Pacemaker Replacement Patients

Identification of Bacteriology and Risk Factor Analysis of Asymptomatic Bacterial Colonization in Pacemaker Replacement Patients

Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices

Implant Related Infections

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