Implant Related Infections

Abraham, Wolf‐Rainer

doi:10.1007/978-3-319-10981-7_11

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The species associated with peri-implantitis have been shown to be the same core species as those associated with periodontitis [ 23 ]. However, the peri-implant microbiota has been reported in some instances to deviate from the periodontitis associated microbiota, with high numbers of staphylococci [ 24–26 ]. Clinical studies have reported high numbers of S. aureus in deep peri-implant pockets with suppuration and bleeding [ 27 , 28 ], and S. aureus is also associated with therapy resistant periodontitis [ 29–32 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of silica nano-spheres on adhesion of oral bacteria and human fibroblasts

Kallas

Hua

Valen

et al. 2020

Biomaterial Investigations in Dentistry

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Objective: This study investigated the effect of surface nano-patterning on adhesion of an oral early commensal colonizer, Streptococcus mitis and the opportunistic pathogen Staphylococcus aureus and human fibroblasts (HDFa) in a laminar flow cell. Methods: Nanostructured surfaces were made by functionalizing glass substrates with 40 nm SiO 2 nanoparticles. Gradients in nanoparticle surface coverage were fabricated to study the effect of nanoparticle spacing within a single experiment. Bacterial adhesion was investigated after 5 min of contact time by subjecting surfaces to a flow in a laminar flow cell. In addition, to examine the particles effect on human cells, the establishment of focal adhesion and spreading of primary human dermal fibroblasts (HDFa) were investigated after 4 and 24 h. Results: Adhesion of both S. aureus and S. mitis decreased on surfaces functionalized with nanoparticles and coincided with higher nanoparticle surface coverage on the surface. Both strains were tested on three separate surfaces. The regression analysis showed that S. mitis was influenced more by surface modification than S. aureus. The establishment of focal adhesions in HDFa cells was delayed on the nanostructured part of the surfaces after both 4 and 24 h of culturing. Significance: In the current manuscript, we have used a flow cell to investigate the effect of nanotopographies on S. aureus and S. mitis adhesion. The present findings are of relevance for design of future implant and prostheses surfaces in order to reduce adhesion of bacteria.

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Section: Introductionmentioning

confidence: 99%

Effect of silica nano-spheres on adhesion of oral bacteria and human fibroblasts

Kallas

Hua

Valen

et al. 2020

Biomaterial Investigations in Dentistry

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“…Bacterial colonization and subsequent biofilm formation on the surfaces of medical materials is a pressing challenge, especially for metallic implant materials such as titanium alloys, magnesium alloys, and 316L stainless steel. , One of the common method to overcome bacterial infections is fabricating coatings containing antibiotics or antimicrobial agents, such as gentamicin, vancomycin, and metal nanoparticles on the implants surface. − However, the use of antibiotics may cause antibiotic resistance. Moreover, the accumulation of dead bacteria might benefit the subsequent formation of bacterial membrane , and lead to the weakening of antibacterial efficiency of coatings. , Therefore, reducing the bacterial adhesion is an effective approach to minimize bacterial infections on implant surfaces …”

Section: Introductionmentioning

confidence: 99%

Zwitterionic-Based Surface via the Coelectrodeposition of Colloid Particles and Tannic Acid with Bacterial Resistance but Cell Adhesion Properties

Meng

Pan

Zhu

et al. 2018

ACS Biomater. Sci. Eng.

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Herein, a hydrophobized zwitterionic-based copolymer poly(sulfobetaine methacrylate-co-2-(dimethylamino)ethyl methacrylate-co-isobornyl acrylate) (P(SBMA-co-DMA-co-ISA), PSDI) containing a chiral structure has been successfully synthesized by free radical polymerization and subsequent sulfonation reactions. Together with tannic acid (TA), PSDI colloidal particles (CPs) were anchored onto the Ti alloy surface by the electrophoretic deposition method. The composition, morphology, and surface properties of the CP-TA composite coatings were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), optical contact angle (OCA), and other methods. The results show that the introduction of TA improves the stability of coatings by participating in the noncovalent interactions including ionic pairing and hydrogen bonding. According to the in vitro bacterial adhesion test, the modified titanium surface containing SBMA and chiral ISA functional units can effectively inhibit Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) adhesion. Furthermore, the excellent cytocompatibility and favorable cell adhesion and growth behavior of zwitterionic-based coatings were realized as a result of the appropriate hydrophobicity provided by the ISA moiety. This work provides a new strategy for preparing zwitterionic-based multifunctional coating. The coating with excellent bacterial and cell selective adhesion properties has great potential in the applications of metal implant materials, such as cardiovascular stents and human hard tissue repair and replacement materials.

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Implant Related Infections

Cited by 2 publications

References 26 publications

Effect of silica nano-spheres on adhesion of oral bacteria and human fibroblasts

Effect of silica nano-spheres on adhesion of oral bacteria and human fibroblasts

Zwitterionic-Based Surface via the Coelectrodeposition of Colloid Particles and Tannic Acid with Bacterial Resistance but Cell Adhesion Properties

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