Zwitterionic-Based Surface via the Coelectrodeposition of Colloid Particles and Tannic Acid with Bacterial Resistance but Cell Adhesion Properties

Abstract

Herein, a hydrophobized zwitterionic-based copolymer poly­(sulfobetaine methacrylate-co-2-(dimethylamino)­ethyl methacrylate-co-isobornyl acrylate) (P­(SBMA-co-DMA-co-ISA), PSDI) containing a chiral structure has been successfully synthesized by free radical polymerization and subsequent sulfonation reactions. Together with tannic acid (TA), PSDI colloidal particles (CPs) were anchored onto the Ti alloy surface by the electrophoretic deposition method. The composition, morphology, and surface properties of the CP-TA composite coatings were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), optical contact angle (OCA), and other methods. The results show that the introduction of TA improves the stability of coatings by participating in the noncovalent interactions including ionic pairing and hydrogen bonding. According to the in vitro bacterial adhesion test, the modified titanium surface containing SBMA and chiral ISA functional units can effectively inhibit Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) adhesion. Furthermore, the excellent cytocompatibility and favorable cell adhesion and growth behavior of zwitterionic-based coatings were realized as a result of the appropriate hydrophobicity provided by the ISA moiety. This work provides a new strategy for preparing zwitterionic-based multifunctional coating. The coating with excellent bacterial and cell selective adhesion properties has great potential in the applications of metal implant materials, such as cardiovascular stents and human hard tissue repair and replacement materials.

Thermally Stable Bioinert Zwitterionic Sulfobetaine Interfaces Tolerated in the Medical Sterilization Process

“…Thus, it can be confirmed that SBMA is more easily hydrolyzed in a PBS environment due to the accelerated hydrolysis of esters in weakly alkaline PBS (pH = 7.4). The use of methacrylate-derived zwitterionic materials in the modification of metallic surfaces to enhance blood compatibility and endothelial cell proliferation is common . However, it is critical to assess if these materials will be stable or if they will undergo hydrolysis in the media they are incubated with.…”

“…The use of methacrylate-derived zwitterionic materials in the modification of metallic surfaces to enhance blood compatibility and endothelial cell proliferation is common. 46 However, it is critical to assess if these materials will be stable or if they will undergo hydrolysis in the media they are incubated with.…”

Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications

“…The borneol-based polymers are hydrophobic and noncytotoxic, which can significantly improve the cell adhesion ability [ 121 , 122 ]; on the other hand, borneol isomers on the material surface contribute to the surface bacterial resistance properties [ 119 , 120 ]. Due to those data, Meng et al [ 123 ] proposed polymerization with borneol based monomer, assuming that the hydrophobicity of zwitterionic polymers might increase, which will promote their cell adhesion ability without compromising their bacterial resistance properties. For this purpose, they synthesized hydrophobized zwitterionic copolymer P-(SBMA- co -DMA- co -ISA) (PSDI) (compound 149 , Figure 43 ), containing borneol based segment isobornyl acrylate (ISA) and zwitterionic moiety SBMA was prepared by sulfonation of P(DMA- co -ISA) (PDI).…”

Surface modification strategies to improve titanium hemocompatibility: a comprehensive review

“… 126 TA and its derivatives are widely used as primers for immobilization of other molecules due to the presence of phenolic hydroxyl groups that could act as hydrogen bond donors. 127 The TA/SS coated surfaces were hydrophilic in nature. These surfaces were repellent to proteins and showed lower platelet adhesion and anti-adhesive bacterial properties ( Fig.…”