The place of non-routine HF-lEF in evaluation of one-year survival: where does the road go from “available prognosis”?

Prokopová, Lucie; Sitnikova, M. Yu.; Dorofeykov, V.; Lelyavina, T. A.; Kashuba, S.M.

doi:10.18087/rhfj.2016.2.2193

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Согласно современным преставлениям, иммунная активация и СВР являются не только маркерами прогрессирования заболевания и неблагоприятного прогноза, но и независимыми факторами высокого риска развития осложнений сердечно-сосудистой патологии [11]. Активация провоспалительных цитокинов -интерлейкинов (ИЛ): ИЛ-1 (α и β), ИЛ-6, ИЛ-8 у больных ИБС и ХСН, вероятно, опосредуется симпато-адреналовой активацией, обусловленной хронической ишемией миокарда, и других органовмишеней (головного мозга, почек), вызванной ею иммунносупрессией, развитием синдрома вторичного иммунодефицита, усилением катаболических процессов [12,13].…”

unclassified

Characteristic of infectious status in patients with acutely decompencated chronic heart failure and its impact on annual prognosis

et al. 2019

View full text Add to dashboard Cite

Aim. The assessment of infectious status in patients with acutely decompensated chronic heart faiure (ADCHF) without evident signs of acute inflammatory stress and its impact on the 1 year prognosis.Material and methods. Totally, 65 patients with ADCHF of ischemic origin investigated, age 67,3±2,3 y.o. All patients were taken markers of phagocytosis and inflammatory stress as well as antibodies to Streptococcus, Cytomegalovirus (CMV), Epstein-Barr virus (VEB), Candida albicans, Toxoplasma gondii, Aspergillus, Mycoplasma hominis and pneumonia and also level of lipopolysaccharids (LPS) of gram-negative bacteriae.Results. More often LPS of gram-negative bacteriae were revealed in patients with ADCHF and further in decreasing order – antibodies to CMV, VEB, Streptococcus, Candida, Aspergillus and LPS. All patients have been infected by at least 2 pathogens, more than 90 % of them had 3 ones or more. Mortality in first 12 months observation correlated with quantity of patient`s pathogenic patterns (r=0,52, p=0,004). Dependency of one-year mortality from degree of viral-bacterial mixt contamination was almost linear. CMV was a monopathogen with strongest correlation with mortality (r=0,39, p=0,001). In patients with more significant infection bigger rate of re-hospitalizations about new ADCHF correlated with number of pathogens was observed (r=0,61, p=0,001).Conclusion. Chronic latent infection with a significant number of pathogens is characteristic of patients with low-ejection ADCHF of ischemic genesis with a significant number of pathogens: more than 90 % of patients had three or more. The most common exogenous pathogens in the study sample of patients with chronic obstructive heart failure were CMV, EBV, and hemolytic streptococcus, of the potentially endogenous ones, gram-negative intestinal bacteria. The number of infectious agents in patients with chronic obstructive heart failure has a direct correlation with deaths and re-admission to hospital with total heart failure within 1 year after discharge from the hospital.

show abstract

unclassified

Characteristic of infectious status in patients with acutely decompencated chronic heart failure and its impact on annual prognosis

et al. 2019

View full text Add to dashboard Cite

show abstract

The role of muscle tissue in the pathogenesis of chronic heart failure — the potential of exposure (FORMA study)

et al. 2019

View full text Add to dashboard Cite

Mortality risk factors in patients who are in heart transplantation waiting list

Федотов

Simonenko

Sazonova

et al. 2022

jour

View full text Add to dashboard Cite

Objective: to estimate the survival of patients in the heart transplantation waiting list (HTx WL) at Almazov National Medical Research Centre (V.A. Almazov NMRC), Saint-Petersburg, Russia, from 2010 to 2018 and to define factors for death among these patients.Materials and methods: it was a single-centre retrospective study involving 151 patients with end-stage chronic heart failure (CHF) classes III-IV (NYHA) in the HTx WL.Results: the dynamic of decreasing mortality was revealed. Based on the results of constructing the discriminant function, four factors predicting the survival of patients in the HTx WL, namely, ACE inhibitors/ARBs, beta-blockers, status 1 of UNOS, CHF NYHA class IV, were pointed out. The model has sufficient resolving power but is not capable of predicting the outcome in the presence of acute decompensation of CHF.Conclusion: mortality in the HTx WL for the period 2010-2018 decreased that was associated with an active implementation of cardiac surgical methods as a «bridge» to transplant and optimal medical therapy, including ACE inhibitors/ARBs and beta-blockers in patients supported with inotropes (UNOS 1B). The greatest risk of mortality was found in CHF class IV and status 1 by UNOS.

show abstract

The place of non-routine HF-lEF in evaluation of one-year survival: where does the road go from “available prognosis”?

Cited by 4 publications

References 0 publications

Characteristic of infectious status in patients with acutely decompencated chronic heart failure and its impact on annual prognosis

Characteristic of infectious status in patients with acutely decompencated chronic heart failure and its impact on annual prognosis

The role of muscle tissue in the pathogenesis of chronic heart failure — the potential of exposure (FORMA study)

Mortality risk factors in patients who are in heart transplantation waiting list

Contact Info

Product

Resources

About