The role of muscle tissue in the pathogenesis of chronic heart failure — the potential of exposure (FORMA study)

Лелявина, Т. А.; Ситникова, М. Ю.; Galenko, V. L.; Козлов, П С; Борцова, М. А.; Демченко, Е. А.; Ганенко, О С; Головкин, А. С.; Kostareva, Anna; Dmitrieva, Renata I.

doi:10.15829/1560-4071-2019-10-58-65

Cited by 8 publications

(9 citation statements)

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“…Physical Rehabilitation (PR) is an important part of treating stable heart failure regardless of its cause or EF levels. Physical training helps to improve clinical state, quality of life, exercise tolerance, EF and VO2peak levels [2][3][4][5]. It is well known that EF and VO2peak both have significant prognostic value in heart failure patients [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that EF and VO2peak both have significant prognostic value in heart failure patients [1,2]. Usually, we observe the positive impact of training in both EF and VO2peak levels [2][3][4][5][6][7]. In some cases, there is not such relationship.…”

Section: Discussionmentioning

confidence: 99%

“…Heart failure with reduced ejection fraction (HFrEF) is usually characterized by low levels of VO2 peak and a poor prognosis despite optimal drug therapy and cardiac device therapy [1,2]. Physical Rehabilitation (PR) is an important part of severe HFrEF treatment [1][2][3][4][5][6]. Long term PR based on lactate threshold achievement during Cardiopulmonary Exercising Test (CPET) in stable HFrEF patients can improve NYHA functional class and VO2 peak [3], while EF in some cases can show no significant dynamics.…”

Section: Introductionmentioning

confidence: 99%

“…Physical Rehabilitation (PR) is an important part of severe HFrEF treatment [1][2][3][4][5][6]. Long term PR based on lactate threshold achievement during Cardiopulmonary Exercising Test (CPET) in stable HFrEF patients can improve NYHA functional class and VO2 peak [3], while EF in some cases can show no significant dynamics. Response to PR is unique in each individual and based on gender, age, skeletal muscle condition [3].…”

Section: Introductionmentioning

confidence: 99%

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Hospital Care in 2000s: Findings from A Large National Database

Regina¹

2020

BJSTR

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Rationale: Heart failure with reduced ejection fraction (HFrEF) is usually characterized by low levels of VO2 peak. Optimal drug therapy, cardiac devices and physical rehabilitation can improve both left ventricle ejection fraction (EF) and levels of VO2 peak. We describe an unusual case of significant discrepancy between VO2 peak and EF dynamics in severe heart failure patient on optimal drug therapy, after long term cardiac device therapy (Optimizer Smart IVs) and physical rehabilitation.Patient Concern: In this report, a 58-year-old male with HFrEF after long term cardiac device therapy (Optimizer Smart IVs) and physical rehabilitation significantly improving VO2 peak. Diagnosis:The patient was diagnosed with coronary artery disease, repeated myocardial infarctions and HFrEF. Interventions:The patient underwent long term cardiac device therapy (Optimizer Smart IVs) and physical rehabilitation based on lactate threshold achievement during cardiopulmonary exercising test. Outcomes:The patient had significant improvement in VO2 peak level, but EF did not change. Conclusion:The difference between VO2peak and EF dynamics may be a result of skeletal muscles oxygen uptake improvement after aerobic physical rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hospital Care in 2000s: Findings from A Large National Database

Regina¹

2020

BJSTR

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“…Потеря мышечной массы, силы и функциональных возможностей могут приводить к повышенной вероятности падений и связанных с ними переломов, развитию синдрома хрупкости, снижению физической работоспособности и качества жизни [4]. Непереносимость физических нагрузок -ключевой симптом при ХСН, который обусловлен не только нарушением гемодинамики, но и изменениями в скелетной мускулатуре [5].…”

Section: Introductionunclassified

Body composition and functional activity in men with heart failure

Skripnikova,

Yaralieva,

Myasnikov

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To assess the body composition and functional activity (FA) parameters in men with heart failure (HF) of various nature depending on the stage, class and echocardiographic characteristics of the disease.Material and methods. The study included 100 men aged 23-70 years. The main group consisted of 60 men with HF, the control group — 40 men without HF. Quantitative body composition assessment (fat, lean and bone body mass) was carried out using dual-energy X-ray absorptiometry (DXA). Physical activity was assessed using handgrip test, short physical performance battery (SPPB) test, 6-minute walk test (6MWT), and Timed Up and Go (TUG) test.Results. In the HF group, there were a significant decrease in total bone mass, trunk and limb bone mass, total muscle mass, trunk and limbs’ muscle mass, appendicular skeletal muscle index (ASMI), and FA as HF class increased. Fat mass did not differ in individuals with different HF class and stage. HF class was an independent factor in the reduction of total bone mass (b=-301,9, p=0,015), total muscle mass (b=-1903, p=0,03), limb bone mass (b=-147,6, p=0,013) and appendicular muscle mass (AMM) (b=-1903, p=0,001). Total bone mass (b=-2,637, p=0,02) and AMM (b=-3,512, p=0,01) were independently associated with the Vasilenko-Strazhesko HF stage. AMM also had an independent association with left ventricular ejection fraction (LVEF) (b=0,274, p=0,03). The average body composition scores did not differ between the study and control groups, while the scores of handgrip test, 6MWT, SPPB and TUG test were significantly worse in the HF group. NYHA HF class, stage of HF, LVEF, left ventricular end-diastolic volume (LVEDV) and pulmonary artery systolic pressure (PASP) made an independent contribution to FA decrease in men with HF.Conclusion. In patients with HF, there was deterioration in musculoskeletal parameters depending on HF class, stage and LVEF, without significant differences compared to the control group. There was no association of fat mass with the disease, clinical and echocardiographic characteristics. The average parameters of muscle strength and tests of FA were reduced in men with HF compared with the control group and depended on the NYHA class and stage of HF, LVEF, LVEDV, and PASP.

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