The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis

Olivares, Carla Noemí; Ricci, Analía Gabriela; Bilotas, Mariela Andrea; Barañao, Rosa Inés; Meresman, Gabriela Fabiana

doi:10.1016/j.fertnstert.2011.05.063

Cited by 58 publications

(44 citation statements)

References 51 publications

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“…Ciglitazone and rosiglitazone reduced the volume and weight of lesions in the murine model of endometriosis compared with controls (83,(87)(88)(89). Inhibition of cell proliferation and vascularization and increased apoptosis were documented with the use of rosiglitazone (83,88,89).…”

Section: Anti-inflammatory Agentsmentioning

confidence: 92%

“…In vivo, celecoxib statistically significantly reduced the number and size of peritoneal endometriosis-like lesions in mice when administered either before or after the induction of lesions (81)(82)(83). Other specific COX-2 inhibitors-rofecoxib, NS-398, and parecoxib-also have been demonstrated to statistically significantly reduce the size of endometriosislike implants, inducing their atrophy and regression (84,85,121).…”

Section: Anti-inflammatory Agentsmentioning

confidence: 98%

See 1 more Smart Citation

Pharmacologic therapies in endometriosis: a systematic review

Soares¹,

Martínez-Varea

Hidalgo-Mora

et al. 2012

Fertility and Sterility

137

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Section: Anti-inflammatory Agentsmentioning

confidence: 92%

Section: Anti-inflammatory Agentsmentioning

confidence: 98%

Pharmacologic therapies in endometriosis: a systematic review

Soares¹,

Martínez-Varea

Hidalgo-Mora

et al. 2012

Fertility and Sterility

137

View full text Add to dashboard Cite

“…К тому же появился ряд статей, указывающих, что длительное или неконтро-лируемое использование селективных НПВС может приводить к нелетальным инфарк там, тромбозам [9,10,20] [22]. В 2008 г. группа ис-следователей под руководством C. Olivares на основании рандомизированного исследования установила опти мальную дозировку целекок-сиба 100 мг [23]. В 2011 г. также C. Olivares et al продемонстрировали на модели мышей с индуцированным эндометриозом эффектив-ность применения целекоксиба в сочетании с ингибитором ароматазы розиглитазоном.…”

Section: The Efficacy Of Selective Cyclooxygenase 2 Inhibitors In Theunclassified

The efficacy of selective cyclooxygenase 2 inhibitors in the treatment of genital endometriosis

et al. 2018

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External genital endometriosis is characterized by the processes of angiogenesis, neurogenesis, impaired apoptosis, local inflammation of the tissues, secretion of estradiol, and cell proliferation. In a similar manner, prostaglandin E2 affects tissues. The safest drugs that overwhelm COX-2 activity and inhibit the expression of prostaglandin E2 are selective COX-2 inhibitors. As a mediator of inflammation, prostaglandin E2 is involved in all inflammatory processes. It induces the expression of local P450 aromatase and the anti-apoptotic gene Bcl-2. E2 also possesses immunosuppressive-mediated activity and inhibits the synthesis of cytokines IFNγ, TNFα, and IL-12, IL-1β-mediated expression of chemokines, the proliferation of T- and B-cells and reduces the cytotoxic activity of NK cells, creating a background of the immunosuppressive characteristic of endometriosis [1–3]. This study included 100 patients of reproductive age (aged 22-35 years) with a confirmed diagnosis of external genital endometriosis of degree II–IV. Fifty patients received 100 mg of celecoxib in monotherapy and in combination with 2 mg of dienoguest. The control group included 50 people receiving monotherapy with 2 mg of dienogest. The effectiveness of therapy was assessed using the visual analog scale (VAS) and on the basis of the dynamics of algodismenorrhea, pain during coitus, clinical examination, and the patient’s subjective assessment of the degree of irritability and severity of depressive syndrome. The effectiveness of the treatment was evaluated according to MRI and ultrasound of the pelvic organs throughout the study. To control for possible complications of the therapy, the patients performed a comprehensive dynamic survey assessing the indicators of general blood analysis and the blood coagulation system. In the group with the combined application of celecoxib and dienoguest, a clinically significant reduction in pain syndrome and a decrease in the degree of irritability and depressive syndrome were noted relative to the control group. No side effects of celecoxib on the body systems were identified throughout the study. Thus, celecoxib can be recommended as a safe and effective combination therapy for endometriosis.

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“…Specimens were sectioned and stained with hematoxylin-eosin for histopathological analysis, which was conducted by an experienced pathologist who was blinded to the study. Qualitative analysis was performed by analyzing the histopathological characteristics (endometriosis level, necrosis, bleeding, inflammatory cells infiltrate and apoptosis) of surgical specimens 10,16 . Quantitative analysis was performed by measuring the percentage of total endometriotic tissue represented by tumor cells using the Kontron KS300 V2.0 (Kontron AG, Eching/ München, Germany) imaging software, as previously reported…”

Section: Gross and Microscopic Analysismentioning

confidence: 99%