Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

Saad-Hossne, Rogério; Barretto, Adriana Beatriz; Siqueira, Juliana Menezes; Denadai, Rafael

doi:10.1590/s0102-865020160040000002

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…A high level of COX-2 due to various factors such as estrogens, hypoxia and environmental pollutants could suppress apoptosis and increase cell proliferation through PGE2 and its receptors EP2, and EP4 in endometriosis (143). In addition, experimental studies with intralesional injections of ASA, in rabbits with peritoneal endometriosis, eliminate endometriotic lesions (144).…”

Section: Lipoxinsmentioning

confidence: 99%

Molecules and Prostaglandins Related to Embryo Tolerance

et al. 2020

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Section: Lipoxinsmentioning

confidence: 99%

Molecules and Prostaglandins Related to Embryo Tolerance

et al. 2020

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“…22 In animal studies, intralesional aspirin injections caused destruction of peritoneal endometriosis. 23,24 Other studies have assessed the effects of herbal antioxidants. 25 Our study indicated that short-term administration of aspirin to women with endometriosis reduced chronic pelvic pain, dysmenorrhea, and dyspareunia in these women.…”

Section: Discussionmentioning

confidence: 99%

The effect of acetylsalicylic acid on pain and recurrence of endometriosis after surgery: A randomized controlled trial

Moini

Azizlou

Hosseini

et al. 2021

Journal of Endometriosis and Pelvic Pain Disorders

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Background: Reactive oxygen species (ROS) might increase growth and adhesion of endometrial cells in the peritoneal cavity, and lead to endometriosis. In this study the we evaluate the effect of an antioxidant, acetylsalicylic acid (aspirin), to determine whether aspirin administration to patients with endometriosis would affect pelvic pain and disease recurrence. Material and methods: This randomized controlled trial was conducted from March 2018 to March 2020 on women, 19 to 40 years of age, who were diagnosed with endometriosis after undergoing laparoscopic surgery. Study participants were randomly assigned to one of two groups, Oral contraceptive pills (OCP) and placebo or OCP and aspirin, which were administered daily for 6 months. Pelvic pain, dysmenorrhea, mass size, and menstrual bleeding were evaluated at 3 and 6 months. Results: There were 38 patients in the aspirin group and 49 participants in the placebo group. The mean dysmenorrhea Visual analog scale (VAS) score after 3 months was 2.24 in the aspirin group and 3.61 in the placebo group. After 6 months, the dysmenorrhea VAS scores were 0.68 (aspirin group) and 2.69 (placebo group) ( p = 0.005 and p = 0.00, respectively). Dyspareunia and pelvic pain showed significant reductions ( p = 0.00). Six patients in the control group and four patients in the aspirin group experienced lesion recurrence ( p = 0.45). Conclusion: The results suggest that aspirin, as an antioxidant, could effectively reduce pain in women with endometriosis. However, additional studies that enroll larger numbers of participants and long-term follow up will enable better evaluation of recurrence.

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“…Platelet depletion or suppression of platelet aggregation is an interesting approach and preclinical studies are running. Primary results with intralesional aspirin injection 44,45 or other antiplatelets are encouraging by effectively reducing lesion growth and the extent of fibrosis 46,50 .…”

Section: Discussionmentioning

confidence: 99%

“…The experimental results of Saad-Hossne et al showed that intralesional aspirin injection resulted in elimination of gross and histological areas of endometriotic tissue, leaving only fibrosis, necrosis, and apoptosis in their place with a good safety profile. As the scar tissue can negatively impact on local tissue function and culminate in clinical manifestations, further investigations should examine the real scar tissue formation rate and its clinical implications, such as fertility, after intralesional aspirin injection 44 . Siquiera et al issued also encouraging results with intralesional injection with aspirin in endometriotic lesions in rabbits 45 .…”

Section: The Role Of Antithrombotic Treatment Antiplatelet Treatment and Platelet Depletionmentioning

confidence: 99%

Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

Kanellopoulou¹

2020

HJOG

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Endometriosis is a chronic inflammatory disease of women of reproductive age that is defined by the presence of ectopic endometrium. The pathophysiology of the disease is poorly understood, however platelet activation play a crucial role in initiation of inflammation and fibrinogenesis, which in term further activate the coagulation cascade. The relationship between inflammation and coagulation motivated researchers to study whether patients are in a hypercoagulable state and if endometriosis represent an independent risk factor for venous thromboembolism or cardiovascular risk. This review article focuses on the role of coagulation, the risk of thrombosis and a possible beneficial effect of antithrombotic-treatment.

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Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

Abstract: PURPOSE:To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis.

Cited by 6 publications

References 39 publications

Molecules and Prostaglandins Related to Embryo Tolerance

Molecules and Prostaglandins Related to Embryo Tolerance

The effect of acetylsalicylic acid on pain and recurrence of endometriosis after surgery: A randomized controlled trial

Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

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