Molecules and Prostaglandins Related to Embryo Tolerance

Andrade, Gabriel Mayoral; Martínez, Gabriela Vásquez; Mayoral, Laura; Hernández-Huerta, María Teresa; Zenteno, Edgar; Mayoral, Eduardo Pérez-Campos; Cruz, Margarito Martínez; Cruz, Raymundo; Matías-Cervantes, Carlos Alberto; Cruz, Noemí Meraz; Díaz, Carlos Romero; Cruz-Parada, Eli; Pérez-Campos, Eduardo

doi:10.3389/fimmu.2020.555414

Cited by 21 publications

(15 citation statements)

References 192 publications

(96 reference statements)

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“…A plausible explanation for the observed differentiation towards immunotolerance in the secretory phase endometrium of mated and proven fecund group of animals could be due to the presence of seminal plasma inducing the observed genomic expression. In fact, evidence based on a series of elegant experiments is now available across various mammalian species to indicate that seminal plasma exerts substantial modifying action on endometrium towards receptivity, ovo-implantation, immunotolerance, embryo development, and establishment of pregnancy [38,52,[57][58][59][60][61][62]. To our knowledge, this is the first report supporting the notion that seminal plasma could induce at the genomic expression level a process bias for immunotolerance to non-self antigens in the secretory phase endometrium of natural conception cycle in the rhesus macaque.…”

Section: Genes Uniquely Expressed In Natural Conception Cycle and Involved In Induction Of Immunotolerance To Non-self Antigens Might Be mentioning

confidence: 99%

Preimplantation Endometrial Transcriptomics in Natural Conception Cycle of the Rhesus Monkey

et al. 2022

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There is no report on preimplantation phase endometrial transcriptomics in natural conception cycles of primates. In the present study, the whole-genome expression array of endometrium on Days 2, 4, and 6 post-ovulation (pov) in proven natural conception (Group 1; n = 12) and non-mated, ovulatory (Group 2; n = 12) cycles of rhesus monkeys was examined, compared, and validated. Of fifteen (15) genes showing differential expression (>2-fold; pFDR < 0.05), six genes (CHRND, FOXD3, GJD4, MAPK8IP3, MKS1, and NUP50) were upregulated, while eight genes (ADCY5, ADIPOR1, NNMT, PATL1, PIGV, TGFBR2, TOX2, and VWA5B1) were down regulated on Day 6 pov as compared to Day 2 pov in conception cycles. On Day 6 pov, four genes (ADCY5, NNMT, TOX2, and VWA5B1) were down regulated, and AVEN was upregulated in conception cycles compared with the non-conception cycle. These observations were orthogonally validated at protein expression level. Group-specifically expressed unique genes in conception cycles influence the process of induction of immune-tolerance, while the genes expressed in both groups influence processes of protein targeting and metabolism. A triad of timed-actions of progesterone, seminal plasma, and preimplantation embryo putatively regulate several input molecules to CREB, NF-kB, and STAT regulatory networks during secretory phase towards evolution of endometrial receptivity in the rhesus monkey.

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Section: Genes Uniquely Expressed In Natural Conception Cycle and Involved In Induction Of Immunotolerance To Non-self Antigens Might Be mentioning

confidence: 99%

Preimplantation Endometrial Transcriptomics in Natural Conception Cycle of the Rhesus Monkey

et al. 2022

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“…In addition to its role in CL maintenance (Waclawik, Blitek, et al, 2009; Waclawik, Jabbour, et al, 2009), the synthesis of prostaglandin by the pig conceptus has also been implicated in endometrial function (Waclawik, Blitek, et al, 2009; Waclawik, Jabbour, et al, 2009). When prostaglandin synthesis is inhibited during early pregnancy, conceptus loss occurs (Mayoral Andrade et al, 2020), suggesting their central role in early embryonic development and survival.…”

Section: Establishment Of Pregnancy: Embryo–maternal Crosstalkmentioning

confidence: 99%

“…When prostaglandin synthesis is inhibited during early pregnancy, conceptus loss occurs (Mayoral Andrade et al, 2020), suggesting their central role in early embryonic development and survival.…”

Section: Establishment Of Pregnancy: Embryo-maternal Crosstalkmentioning

confidence: 99%

Context is key: Maternal immune responses to pig allogeneic embryos

Martínez

Rodriguez‐Martinez

2022

Molecular Reproduction Devel

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Successful establishment of pregnancy includes the achievement of a state of immune tolerance toward the embryos (and placenta), where the well-coordinated maternal immune system is capable of recognizing conceptus antigens while maintaining maternal defense against pathogens. In physiological pregnancies, following natural mating or artificial insemination (AI), the maternal immune system is exposed to the presence of hemi-allogeneic embryos, that is, embryos containing maternal self-antigens and foreign antigens from the paternal side. In this scenario, the hemi-allogeneic embryo is recognized by the mother, but the immune system is locally modified to facilitate embryo implantation and pregnancy progression. Pig allogeneic pregnancies (with embryos containing both paternal and maternal material foreign to the recipient female), occur during embryo transfer (ET), with conspicuously high rates of embryonic death. Mortality mainly occurs during the peri-attachment phase, suggesting that immune responses to allogeneic embryos are more complex and less efficient, hindering the conceptuses to survive to term.Reaching a similar maternal tolerance as in conventional breeding would render ET successful. The present review critically summarizes mechanisms of maternal immune recognition of pregnancy and factors associated with impaired maternal immune response to the presence of allogeneic embryos in the porcine species.

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“…The ratio of different PUFAs in the diet changes the phospholipid composition of the cell membrane, which is crucial in terms of quantity, since each group of PG precursors is competing for the same enzyme system for metabolism [ 44 ]. This, in turn, can have a significant impact on the type of PG synthesis and physiological response [ 45 ].…”

Section: Pufas Pgs Cox-2 Cox-1 and Endometrial Receptivitymentioning

confidence: 99%

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

et al. 2021

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Endometrial receptivity plays a crucial role in fertilization as well as pregnancy outcome in patients faced with fertility challenges. The optimization of endometrial receptivity may help with normal implantation of the embryo, and endometrial receptivity may be affected by numerous factors. Recently, the role of lipids in pregnancy has been increasingly recognized. Fatty acids and their metabolites may be involved in all stages of pregnancy and play a role in supporting cell proliferation and development, participating in cell signaling and regulating cell function. Polyunsaturated fatty acids, in particular, are essential fatty acids for the human body that can affect the receptivity of the endometrium through in a variety of methods, such as producing prostaglandins, estrogen and progesterone, among others. Additionally, polyunsaturated fatty acids are also involved in immunity and the regulation of endometrial decidualization. Fatty acids are essential for fetal placental growth and development. The interrelationship of polyunsaturated fatty acids with these substances and how they may affect endometrial receptivity will be reviewed in this article.

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Molecules and Prostaglandins Related to Embryo Tolerance

Cited by 21 publications

References 192 publications

Preimplantation Endometrial Transcriptomics in Natural Conception Cycle of the Rhesus Monkey

Preimplantation Endometrial Transcriptomics in Natural Conception Cycle of the Rhesus Monkey

Context is key: Maternal immune responses to pig allogeneic embryos

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

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