Pharmacologic therapies in endometriosis: a systematic review

Soares, Sérgio Reis; Martínez-Varea, Alicia; Hidalgo-Mora, Juan José; Pellicer, António

doi:10.1016/j.fertnstert.2012.07.1120

Cited by 137 publications

(113 citation statements)

References 202 publications

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“…Various therapies have been used in an attempt to treat endometriosis, including ovarian suppression therapy, surgical treatment, or a combination of these strategies. The knowledge of the high local oestrogen effects on the severity of disease leads to medical hormonal suppression via progesterone, oestrogen and progesterone combinations, GnRH analogues, danazole and gestrinone (44). Aromatase inhibitors like letrozole and anastrazole are used to inhibit oestrogen formation from androgenic precursors; TNF-α inhibitors are used to inhibit the mechanism of inflammation which leads to propagation of disease.…”

Section: Discussionmentioning

confidence: 99%

“…Aromatase inhibitors like letrozole and anastrazole are used to inhibit oestrogen formation from androgenic precursors; TNF-α inhibitors are used to inhibit the mechanism of inflammation which leads to propagation of disease. Anti-angiogenic substances and inhibitors of matrix metalloproteinase are used to inhibit further invasion of endometriosis through natural surfaces (44). However, the adverse effects of these treatments limit their long-term use.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Kocadal¹,

Attar²,

Yıldırım³

et al. 2013

J Turkish German Gynecol Assoc

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Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model. Material and Methods:This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.Results: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. Conclusion: Abstract ÖzetOriginal Investigation 81

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Kocadal¹,

Attar²,

Yıldırım³

et al. 2013

J Turkish German Gynecol Assoc

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“…Следует также помнить, что дефицит прогестерона в сочетании с относительной гиперэстрогенемией у боль-ных НГЭ является благоприятным условием для прогрес-сирования заболевания [36].…”

Section: пролактин и его рецепторы в патогенезе нгэunclassified

“…Механизмы подавления ангиоге-неза агонистами дофамина не до конца изучены. Предпо-лагается, что это может быть опосредованное через дофа-миновые рецепторы -D 2 угнетение (фосфорилирование) рецептора 2-го типа VEGF (VEGFR 2 ) и, как следствие, изменение передачи внутриклеточных сигналов, а также непосредственное угнетение экспрессии VEGF и VEGFR 2 [36].…”

Section: возможности терапии агонистами дофамина в экспериментальных unclassified

The significance of prolactin in the pathogenesis of genital endometriosis and the possibilities of dopamine agonist therapy

Molotkov¹,

Yarmolinskaya²

2015

Ross. vestn. akush.-ginekol.

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“…Role of PEDF in the reproductive system R57 endometriosis (Soares et al 2012), menorrhagia (Bouchard 2011), breakthrough bleeding (Lockwood 2011), and repeated implantation failure, secondary to impaired endometrial receptivity (Torry et al 2007). Endometriosis is a gynecological condition in which endometrial tissue (lesions) is present outside of the uterus usually on the peritoneum and ovaries, and is associated with infertility, dysmenorrhea, dyspareunia, and chronic pelvic pain.…”

Section: The Role Of Pedf In Endometrial Physiology and Pathologymentioning

confidence: 99%

Role of pigment epithelium-derived factor in the reproductive system

Chuderland¹,

Ben‐Ami²,

Bar‐Joseph³

et al. 2014

Reproduction

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The physiological function of the female reproductive organs is hormonally controlled. In each cycle, the reproductive organs undergo tissue modifications that are accompanied by formation and destruction of blood vessels. Proper angiogenesis requires an accurate balance between stimulatory and inhibitory signals, provided by pro-and anti-angiogenic factors. As with many other tissues, vascular endothelial growth factor (VEGF) appears to be one of the major pro-angiogenic factors in the female reproductive organs. Pigment epithelium-derived factor (PEDF) is a non-inhibitory member of the serine protease inhibitors (serpin) superfamily, possessing potent physiologic anti-angiogenic activity that negates VEGF activity. The role of PEDF in decreasing abnormal neovascularization by exerting its anti-angiogenic effect that inhibits pro-angiogenic factors, including VEGF, has been investigated mainly in the eye and in cancer. This review summarizes the function of PEDF in the reproductive system, showing its hormonal regulation and its anti-angiogenic activity. Furthermore, some pathologies of the female reproductive organs, including endometriosis, ovarian hyperstimulation syndrome, polycystic ovary syndrome, and others, are associated with a faulty angiogenic process. This review illuminates the role of PEDF in their pathogenesis and treatment. Collectively, we can conclude that although PEDF seems to play an essential role in the physiology and pathophysiology of the reproductive system, its full role and mechanism of action still need to be elucidated.Reproduction (2014) 148 R53-R61

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Pharmacologic therapies in endometriosis: a systematic review

Cited by 137 publications

References 202 publications

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

The significance of prolactin in the pathogenesis of genital endometriosis and the possibilities of dopamine agonist therapy

Role of pigment epithelium-derived factor in the reproductive system

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