The importance of determining procalcitonin and C reactive protein in different stages of sepsis

Abstract

Rapid and early diagnosis of systemic infections is very important for acting on time with an adequate therapy. e aim of this study is to determine the diagnostic importance of procalcitonin (PCT) and Creactive protein (CRP) of bacterial infections in diff erent stages of sepsis. PCT and CRP have been determined in  newborns, - days of age, with diff erent stages of sepsis, in the centre for prematurely born neonates. ese parameters have also been determined for control group, in which there were  healthy newborns. Procalcitonin values were signifi cantly increased in neonates with septic shock (, ng/mL; ,- ng/mL) compared to the systemic infl ammatory response syndrome-SIRS ( ng/mL; ,- ng/mL), neonatal sepsis (, ng/mL; ,-, ng/mL), neonatal sepsis and purulent meningitis (, ng/mL; ,-, ng/mL). e control group values were lower than , ng/mL. CRP is increased without statistical diff erences in all stages of sepsis in newborns with septic shock (, mg/L; ,- mg/L) in cases with SIRS (, mg/L; ,- mg/L), neonatal sepsis (, mg/L; - mg/L), neonatal sepsis and purulent meningitis (, mg/L; - mg/L).e average values for the control group were , mg/L. Procalcitonin is increased in all stages of sepsis with higher values in the septic shock. e increase of PCT levels is related to the severity, course of infection and prognosis of disease.KEY WORDS: procalcitonin (PCT), C reactive protein (CRP), infection, sepsis, septic shock.

Procalcitonin and intestinal ischemia: A review of the literature

“…The normal level (from the third postnatal day onwards) is below 0.05 ng/mL. After surgery, the PCT level can rise to as much as 1 ng/mL (in cases of minor or aseptic surgery) or even 2 ng/mL (in cardiac surgery) [30,31] . The half-life-time of PCT is between 18 and 24 h, in patients with kidney failure, between 24 and 30 h (with a peak at 24 h) [31] .…”

The Dynamic Measurement of Procalcitonin in Neonatal Purulent Meningitis

“…Among several infectious conditions including neonate purulent meningitis the PCT level was a more sensitive indicator than Creactive protein (CRP), although the increased range of the PCT levels in neonate purulent meningitis was overlapped with systemic inflammatory response syndrome (SIRS) and neonatal sepsis [10]. PCT levels were found significantly higher in patients with bacterial meningitis and other CSF parameters, such as blood leukocytes, and CRP showed overlapping values [11].…”

Kinetics of Procalcitonin in the Management of Small Bowel Obstruction: A Preliminary Report

“…The choice of serum PCT as a biomarker for SBO's management lies on its half life time (24 hours) [16]. As reported by numerous previous works [17][18][19][20][21], in case of inflammatory state (for example SBO), cytokines such as IL6, IL8 and TNFα are released inducing a secretion of PCT but in case of conservative management's success (mainly during the first day after the nasogastric tube suction's beginning) the inflammatory state decreases quickly so the PCT secretion does. Complementary to these works, the data from Nagata et al [22]; Markogiannakis et al [23]; Karabulut et al [24] and Ayten et al [25] had already presented PCT as a possible biomarker.…”