One of the largest therapeutic problem during the continuous treatment of the patients with Hemophilia A and B, are viral infections as Hepatitis B and C, and HIV, and the other infective diseases, which can be transmitted by the transfusion of blood products. Th e aim of this study is to analyze the complications of the hemophiliacs in Kosovo which have been treated with fresh frozen plasma, cryoprecipitate and concentrated products of FVIII and FIX. We have tested patients with hemophilia A or B and there were used enzyme immunoassay test-Elisa method for the following: anti-HCV, HBsAg, HIV and TPHA. Th e serological data showed that HCV infection was positive in cases or ,, whereas infection with HBV and HIV were present in a smaller percentage of the patients (, HBV and , for HIV). HCV infection was present only in , of the cases of the age group under years. Infected hemophiliacs with one or two infective agents were found in ,, respectively . Infection with T. pallidum was present at none of the examined patients with hemophilia. HCV infection was higher in severe forms of hemophilia B (,), compared with severe form of hemophilia A (). Based on our results, despite the infrequent application of FVIII and FIX concentrates, and other anti hemophilic preparations used in treating hemophilia patients, the number of infected hemophiliacs with blood-transmittable infectious agents was substantially high, especially with hepatitis C virus.
Introduction: Numerous studies have reported a high prevalence of Helicobacter pylori infection among healthy and non-healthy persons in different places. The Aim of the study is to investigate the seroprevalence of H. pylori infection among Kosovo’s Blood donor associated with ABO/Rhesus blood group.Methods: 671 blood donors are tested for H. pylori antibodies and results are classifi ed by way of donation, age, gender, blood groups and education level. Serum antibodies are analyzed by Enzyme Linked Fluorescent Assay test for H. pylori IgG with Biomerieux HPY-VIDAS.Results: The frequency of IgG antibody for H. pylori among healthy blood donors is 56.9%, there is not found any difference between voluntary and non-voluntary blood donors (57.4% respectively 56.3%)(OR=1.05; 95% CI 0.76 to 1.43; p=0.8). H pylori IgG antibodies positive are detected in 57.0 % ( 126 of 221) of women, compared with 56.9 % ( 256 of 450) of men(OR=0.99; 95% CI 0.72 to 1.38; p=0.96). Serpositive donors are older than seronegative ones (31.9 years, respectively 29.5 years, p=0.02). Mean value of IgG antibody of H. pylori is 3.61 with no significant difference between males and females (3.72 respectively 3.44; p=0.2). The seroprevalence of H. pylori infection is similar among blood groups: O (57.4%), A (56.2%), B (59.6%), AB (51.4%), RhD positive (56.7%) and RhD negative (58.3%).Conclusions: The seropositivity of H. pylori is moderately higher in the non voluntary and familiar blood donors among the total Kosovo blood donors. There is not found a significant relationship between infection with H. pylori and ABO/Rhesus blood group among blood donors.
Rapid and early diagnosis of systemic infections is very important for acting on time with an adequate therapy. e aim of this study is to determine the diagnostic importance of procalcitonin (PCT) and Creactive protein (CRP) of bacterial infections in diff erent stages of sepsis. PCT and CRP have been determined in newborns, - days of age, with diff erent stages of sepsis, in the centre for prematurely born neonates. ese parameters have also been determined for control group, in which there were healthy newborns. Procalcitonin values were signifi cantly increased in neonates with septic shock (, ng/mL; ,- ng/mL) compared to the systemic infl ammatory response syndrome-SIRS ( ng/mL; ,- ng/mL), neonatal sepsis (, ng/mL; ,-, ng/mL), neonatal sepsis and purulent meningitis (, ng/mL; ,-, ng/mL). e control group values were lower than , ng/mL. CRP is increased without statistical diff erences in all stages of sepsis in newborns with septic shock (, mg/L; ,- mg/L) in cases with SIRS (, mg/L; ,- mg/L), neonatal sepsis (, mg/L; - mg/L), neonatal sepsis and purulent meningitis (, mg/L; - mg/L).e average values for the control group were , mg/L. Procalcitonin is increased in all stages of sepsis with higher values in the septic shock. e increase of PCT levels is related to the severity, course of infection and prognosis of disease.KEY WORDS: procalcitonin (PCT), C reactive protein (CRP), infection, sepsis, septic shock.
One of the most frequent hereditary causes of thrombophilia is, without a doubt, resistance to Activated Protein C (APC-resistance), which is a consequence of point mutation in gene coding for coagulation Factor V (Factor V Leiden) in - of cases. Th e aim of this paper was to determine prevalence of APC-resistance in a group of healthy blood donors. Th e size of the group is quite representative of Kosovo Albanians. A total of blood donors were examined ( males and females), for whom APC-resistance was determined by functional methods of coagulation using the kit ACTICLOT® Protein C Resistance. Method is based on the test of APTT determined twice: fi rst in the presence and second in the absence of activated Protein C (APC). Th e ratio of these two values constitutes is called Activated Protein C -Sensitivity Ratio (APC-SR). From examined donors, pathologic values of APC-SR (,-,) were found in persons (, of the total number). Th e distribution among sexes was , (/) in male and , (/) in female subjects. Th e mean values of APC-SR (, in male and , in female subjects) were not signifi cantly diff erent (P = ,). Based on these results, we conclude that the prevalence of APC resistance in Albanian population of Kosovo is within the lower limit of prevalence in general population in diff erent countries of European countries, which, according to some authors ranges is from to .
Introduction: Transfusion treatment (TT) is necessary in patients with gastrointestinal bleeding (GIB) for lost blood substitution. This study was aimed at assessing the changes in haematological parameters (hemoglobin, hematocrit, red blood cell count, white cell count, platelet count and prothrombin time) before and after TT in anaemic patients with GIB in order to analyse the effect of this treatment.Methods: There have been included 293 patients with GIB (the average age was 57.3, ranged from 18-89 years) who were treated with TT at the Internal Clinic at the University Clinical Center Prishtina during oneyear period. Data for applied blood product and results of the coagulation screen (PT) were collected from the Kosovo’s Blood Transfusion Center (KBTC).Results: TT has been carried out in 404 episodes, with 714 units of concentrated red blood cells (78.6%), 189 units of fresh frozen plasma (20.8%) and concentrated platelets (0.6%), with an average dose 3.1 fortransfunded patients. Average values of Hb before and after TT were 71.8 g/L and 81.4 g/L, respectively; while the average values of hematocrite before and after TT were 22.9% and 25.6%, respectively. The averageerythrocytes count before TT was 2.6 respectively after treatment 2.8(p<0.0001). The PT was carried out in the 43% of patients with GIB before treatment with FFP, but after that only in 2% of cases.Conclusions: Having in mind difficult clinical and unsustainable situation in patients with gastrointestinal bleeding, the Transfusion Treatment resulted in the considerable improvement of the specific blood indicators.
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