Transfusion-Transmitted Infections in Haemophilia Patients

Zhubi, Bukurije; Mekaj, Ymer; Baruti, Zana; Bunjaku, Ilirijane; Belegu, Mazllum

doi:10.17305/bjbms.2009.2777

Cited by 18 publications

(17 citation statements)

References 43 publications

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“…Zhubi et al. showed that in patients with haemophilia in Kosovo, HCV infection was present in 38.7%, whereas HBV was present in 2.7%, and HIV infection was found in 1.4% [15]; their figure for HCV prevalence was very similar to ours. According to Alavian et al.…”

Section: Discussionsupporting

confidence: 85%

Attitudes of haemophilic patients towards their health and socio‐economic problems in Iran

et al. 2011

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Although new technologies and treatments have improved the quality of life of people with haemophilia, they still face many health and socio-economic problems. We designed this study to identify some of these problems according to patients' attitudes towards efforts to solve them. This cross-sectional study was conducted in Shiraz, southern Iran, during January and May 2010. The participants were 100 patients with haemophilia who were referred to Shiraz Hemophilia Center, a major referral centre in southern Iran. A questionnaire was used to obtain data on the attitudes of haemophilic patients about some of their health and socio-economic problems. Mean age of the patients was 28.2 ± 9.0 (range of 16-67 years). In univariate analysis, disease severity, joint involvement, HCV status, income level and educational level of the patients were found to have possible effect on patients' attitude towards their health and socio-economic problems. However, in multivariate model we found that only income level, educational level and HCV status as independent factors influencing the patients' attitude towards childbearing, employment problems, occupational problems, social and friend relationship and continuing education. Haemophilic patients had many social and health problems, which could be alleviated with interdisciplinary interventions to improve their quality of life. Financial support of these patients should be taken into account to reduce their economic problems. Also, encouraging them and providing facilities to achieve a higher educational level could help them to have a better attitude towards their health and overcome the disease-related problems.

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Section: Discussionsupporting

confidence: 85%

Attitudes of haemophilic patients towards their health and socio‐economic problems in Iran

et al. 2011

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“…HCV infection is considered one of the most relevant causes of morbidity and mortality in patients with hereditary bleeding disorders, especially hemophilia A. Most hemophilia A patients have been infected by HCV during receiving plasma derivatives before the implementation of compulsory blood donors screening [Zhubi et al, 2009; Zoulim and Bailly, 2012].…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory/regulatory cytokine microenvironment mediated by IL‐4 and IL‐10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus

Pimentel

Chaves

Araújo

et al. 2013

Journal of Medical Virology

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In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral blood from hemophilia A patients and other patients with and without HCV infection were studied. The results demonstrated that hemophilia A is characterized by a general state of circulating leukocytes activation along with an overall increase in the frequency of IL-6 and IL-10 with decrease of IL-8 and IL-12. HCV infection of patients with hemophilia A does not influence further the activation state of circulating leukocytes but is accompanied by lower levels of alanine transaminase (ALT) and a prominent anti-inflammatory/regulatory serum cytokine pattern, mediated by IL-4 and IL-10. Additionally, the results demonstrated that hemophilia A patients infected with HCV displaying No/Low antibody response to C33c and C22 have significant lower viral load and higher serum levels of IL-12 and IL-4. This finding suggests that the differential RIBA reactivity to C33c/C22 HCV core proteins may have a putative value as a prognostic biomarker for the infection in hemophilia A patients.

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“…HCV infections in cases of age under 18 years was only 9.5%. [17] Morfini, et al . from Italy studied on 708 hemophiliacs patients, infused for the first time before 1985 (group A) and 80 patients, infused for the first time between 1985 and 1991 (group B).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of hepatitis C, hepatitis B and HIV viruses in hemophiliacs born 1985-2010 in west Azarbaijan of Iran

Valizadeh¹,

Nateghi²,

Noroozi³

et al. 2013

Asian J Transfus Sci

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Background:Although, in the past the risk of transfusion transmitted viral infections were high in hemophilia patients, but introduction of viral inactivation methods in1985,decreased the risk of human immunodeficiency and hepatitis C and B viruses transmission significantly. The aim of study was seroprevalence of hepatitis B surface antigen (HBs Ag), hepatitis C virus antibody (HCV Ab) and human immunodeficiency virus antibody (HIVAb) in hemophiliacs in west Azarbaijan of Iran, born in 1985-2010.Materials and Methods:In a cross-sectional study, fifty patients with hereditary bleeding disorders born in 1985-2010, from total 250 patients who had been registered in Urmia Hemophilia Society were enrolled through the year 2010 to assess their seroprevalence for HCV Ab, HIV Ab and HBs Ag. Thirty five of 50 patients had hemophilia. Also; we performed a subset analysis for hemophilia patients.Results:All 50 patients with hereditary bleeding disorders including 35 patients with hemophilia were seronegative for HIV Ab and HBs Ag. HCV-Ab was detected in serum of 3 of 50 (6%) patients with bleeding disorders. After subset analysis for hemophilia (A and B) patients, we found HCV infection in 8.57% (3 of 35) of hemophiliacs.Conclusion:In this study prevalence of HCV infection was very smaller than similar studies in Iran and other countries. This study shows the safety of using viral inactivated factor concentrates and recombinant factors after year 1985. None of Hemophiliacs were seropositive for HIV Ab and HBs Ag.

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Transfusion-Transmitted Infections in Haemophilia Patients

Cited by 18 publications

References 43 publications

Attitudes of haemophilic patients towards their health and socio‐economic problems in Iran

Attitudes of haemophilic patients towards their health and socio‐economic problems in Iran

Anti‐inflammatory/regulatory cytokine microenvironment mediated by IL‐4 and IL‐10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus

Seroprevalence of hepatitis C, hepatitis B and HIV viruses in hemophiliacs born 1985-2010 in west Azarbaijan of Iran

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