Kinetics of Procalcitonin in the Management of Small Bowel Obstruction: A Preliminary Report

C, Sabbagh C Cosse

doi:10.4172/2161-1076.1000184

Cited by 6 publications

(10 citation statements)

References 21 publications

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“…We reported that when measured with the Kryptor TRACE method, the PCT values ranged from 0.29 ng/mL to 2.03 ng/mL in patients with ischemia. Moreover, we validated these data in a second, distinct cohort of 59 patients treated for small bowel obstruction by showing that PCT values (measured with the same assay) ranged from 0.06 ng/mL to 8.1 ng/mL in individuals with intraoperatively confirmed ischemia [37] . Our group also evaluated the value of PCT for characterizing tissue damage in cases of intestinal ischemic diseases (including ischemic colitis and mesenteric infarction) [38] .…”

Section: Assay Methodsmentioning

confidence: 70%

“…Nagata et al [36] Open aortic surgery 93 < 0.5 -> 10 Immunochromatographic test Markogiannakis et al [22] Small and large bowel obstruction 242 4.89-14.35 LUMItest Cosse et al [23] Small bowel obstruction 166 0.29-2.03 Kryptor TRACE Cosse et al [37] Small bowel obstruction 59 0.06-8.1 Kryptor TRACE Cosse et al [38] Ischemic disease (ischemic colitis and mesenteric infarction) 99 0.217-621.2 Kryptor TRACE Table 3 Diagnostic utility of procalcitonin for the diagnosis of intestinal ischemia clinical trial [23] . We reported that when measured with the Kryptor TRACE method, the PCT values ranged from 0.29 ng/mL to 2.03 ng/mL in patients with ischemia.…”

Section: Assay Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Procalcitonin and intestinal ischemia: A review of the literature

Cossé¹,

Sabbagh²,

Kamel³

et al. 2014

WJG

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Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery. At present, there are no diagnostic tools for the early diagnosis of intestinal ischemia. In the last decade, procalcitonin (PCT) has been suggested as a marker of this condition. Here, we review the use of PCT as a diagnostic tool for intestinal ischemia. Two reviewers independently searched the PubMed and EMBASE databases for articles on intestinal ischemia and PCT. They then considered (1) the criteria applicable to preclinical and clinical data; and (2) PCT's predictive value in the diagnosis of intestinal ischemia. Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy. Between 1993 and 2014, seven studies (including two preclinical studies and five clinical studies) dealt with the use of PCT to diagnose intestinal ischemia. Procalcitonin's sensitivity, specificity, positive predictive value and negative predictive value ranged between 72% and 100%; 68% and 91%; 27% and 90% and 81% and 100%, respectively. The area under the receiver operating characteristic curve ranged from 0.77 to 0.92. In view of the preclinical and clinical data, we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Procalcitonin; Intestinal; Ischemia; Diagnosis; Review Core tip: The serum procalcitonin level is clinically relevant for the diagnosis of intestinal ischemia. In the diagnosis of intestinal ischemia, procalcitonin's sensitivity is greater than 70% and its negative predictive value is greater than 80%.

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Section: Assay Methodsmentioning

confidence: 70%

Section: Assay Methodsmentioning

confidence: 99%

Procalcitonin and intestinal ischemia: A review of the literature

Cossé¹,

Sabbagh²,

Kamel³

et al. 2014

WJG

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“…These mediators induce the release of PCT from intestinal macrophages and hepatocytes through the portal system 14 . A prospective non-randomized study conducted with 59 patients diagnosed with small bowel obstruction showed that the surgical treatment achieved cutoff value by measuring PCT levels every 6 h. The cutoff value was 0.16 ng/mL at first admission and was >0.27 ng/mL at the 18th hour 15 . In another study of 242 cases that predicted surgical treatment, the authors emphasized that PCT levels in the treatment of ileus could play an essential role in clinical decision-making in acute bowel obstruction, and they proceeded to surgery with value >1 ng/mL 16 .…”

Section: Discussionmentioning

confidence: 99%

Do biomarkers have predictive value in the treatment modality of the patients diagnosed with bowel obstruction?

Şahin

Gülen

Acehan

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVES: This study aimed to investigate the ability of the biomarkers to predict the surgery treatment and mortality in patients above 18 years of age who were hospitalized with the diagnosis of bowel obstruction from the emergency department.METHODS: This is a 2-year retrospective study. The patients' demographic data, laboratory parameters on admission to emergency department, treatment modalities, and the length of hospital stay were recorded. Patients were divided into two groups: conservative and surgical treatment. Statistical analysis was performed to investigate the value of biomarkers in predicting mortality and the need for surgery. Data were analyzed using IBM SPSS version 22.RESULTS: A total of 179 patients were included in this study. Of these, 105 (58.7%) patients were treated conservative and 74 (41.3%) were treated operatively. The elevated procalcitonin (PCT) level, C-reactive protein, blood urea nitrogen-to-albumin ratio, and lactate-to-albumin ratio were significantly correlated with surgical treatment, length of hospital stay, and mortality. procalcitonin threshold value of 0.13 ng/mL was able to predict the need for surgical treatment, with a sensitivity of 79% and a specificity of 70.3%. Procalcitonin threshold value of 0.65 ng/mL was able to predict the mortality rate of the patients, with a sensitivity of 92.9% and a specificity of 78.1%.CONCLUSIONS: Biomarkers, especially procalcitonin, may be useful in bowel obstruction treatment management and may predict mortality.

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“…In 2005, Ayten et al reported for the rst time the association between procalcitonin (PCT) increase and I/N in rabbits (12). Subsequently, multiples studies investigated the role of PCT in the management and prognosis of adult patients with adhesive small bowel obstruction (ASBO) showing encouraging results (13)(14)(15)(16)(17)(18). In 2017, we published the rst study in pediatric patients that demonstrated correlation between the increase in PCT and presence of I/N in patients with ASBO (19) and suggested that a PCT greater than 1.0 ng/ml should be indicative of surgical management due to this association.…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, this study was exclusive for patients with ASBO including those managed with medical treatment and surgery; we got some false negatives, which we believe were from taking PCT every 24 hours or maybe because we granted that ABSO that didn't require surgery had no I/N. In the current study, we only included patients with IO who required surgical intervention, meaning we were certain of the presence/absence of I/N and we attempted to reduce false negatives by taking the last sample of PCT immediately before surgery knowing the report that recommended taking PCT more frequently (15).…”

Section: Introductionmentioning

confidence: 99%

Role of Procalcitonin in the Timely Detection of Ischemia and Necrosis in Children With Intestinal Obstruction

Dominguez-Muñoz

Dávila-Pérez

Fernandez-Portilla

et al. 2022

Preprint

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Introduction: Procalcitonin (PCT) has been studied for early identification of ischemia and/or necrosis (I/N) in children with intestinal obstruction (IO) secondary to adhesive small bowel obstruction (ASBO). However, the causes of IO in children are numerous. Purpose: To correlate the level of PCT with the presence of I/N.Results: Fifty-seven patients were analyzed. The incidence of I/N was 36%. PCT median was statistically higher in patients with I/N compared to those patients with normal intestine: 4.13 (13.9) vs 0.11 (0.28) ng/ml, p = <0.001. A PCT threshold >1.17 ng/ml for predicting I/N yielded a sensitivity of 90%, a specificity of 97%, a positive predictive value (PPV) of 95%, a negative predictive value (NPV) of 94%, p = <0.001, relative risk (RR) 17.57 (95%CI, 4.54 – 67.90). Similarly, a PCT threshold >1.41 ng/ml for predicting intestinal necrosis yielded a sensitivity of 92%, a specificity of 88%, a PPV of 72%, a NPV of 97%, p = <0.001, RR 28.16 (95%CI, 3.98 – 119.12).Conclusions: This study corroborates the association of PCT with IN in children with IO and expands the evidence of its use in this field. Similarly, suggests a PCT threshold >1.17 ng/ml and >1.41 for predicting IN and intestinal necrosis respectively.

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Kinetics of Procalcitonin in the Management of Small Bowel Obstruction: A Preliminary Report

Abstract: The PCT kinetics' study participants were divided into two groups: patients in whom the CM was successful (the CM group, n=47) and those in whom it had failed (the SM group, n=12).

Cited by 6 publications

References 21 publications

Procalcitonin and intestinal ischemia: A review of the literature

Procalcitonin and intestinal ischemia: A review of the literature

Do biomarkers have predictive value in the treatment modality of the patients diagnosed with bowel obstruction?

Role of Procalcitonin in the Timely Detection of Ischemia and Necrosis in Children With Intestinal Obstruction

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