The Hl-a System and the Mixed Lymphocyte Reaction

Pentycross, C. R.; Klouda, P. T.; Lawler, SylviaD.; Jenkins, D.M.

doi:10.1016/s0140-6736(72)90094-3

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…(i) negative MLC reactions between HL-A non-identical siblings (Bach & Amos 1967, Amos & Bach 1968, Dupont et al 1971, Gatti et al 1971, Lebrun et al 1971, Eijsvoogel et al 1972a ; (ii) positive MLC reactions between HL-A identical siblings (Amos & Bach 1968, Bach et al 1969, Plate et al 1970) ; (iii) negative MLC reactions between HL-A non-identical siblings and positive MLC reactions between HL-A identical siblings, combined in one family , Eijsvoogel et al 1972a,b, Mempel et al 1972, Sasportes et al 1972, Dupont et al 1974 ; positive MLC reactions between HL-A identical unrelated individuals (Kissmeyer-Nielsen et al 1970, van Rood & Eijsvoogel 1970, Slarensen & Staub Nielsen 1970, Eijsvoogel et al 1971, Sengar et al 1971, Mempel et al 1973a ; negative MLC reactions between HL-A non-identical unrelated individuals (Pentycross et al 1972, BlussC van Oud Alblas, personal communication, Mempel et al 1973a, van den 'Tweel et al 1973).…”

mentioning

confidence: 99%

An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

et al. 1975

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mentioning

confidence: 99%

An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

et al. 1975

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“…Support for this hypothesis has been provided by Pentycross et al [25] pronounced mixed lymphocyte reactivity [3, 4, 14, 15].…”

Section: Discussionmentioning

confidence: 73%

HL-A Typing in Families of Potential Kidney Recipients

Sybesma¹,

Overbeeke²,

Borst-Eilers³

et al. 1973

Vox Sanguinis

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HL-A typing was performed in 22 potential kidney recipients, 35 parents and 87 siblings. Homozygosity for one or two HL-A antigens was present in about half of the patients with a phenotypic incomplete HL-A pattern. In 12 patients 23 HL-A identical siblings were found. In one patient recombination of the paternal first and second locus of the HL-A system was observed. Mixed lymphocyte reactions (MLR) were carried out with 3 sibs and an unrelated donor. A difference at the first HL-A locus was accompanied by a weak mixed lymphocyte reactivity, while a difference at the second HL-A locus gave rise to a strong MLR. Our findings support the hypothesis of two MLR loci localized closely to the HL-A loci.

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“…It is now generally supposed that the MLR is dependent upon one or more loci separate from, but localized closely to the HL-A loci. Support for this hypothesis has been provided by PENTYCROSS et al [25] who found a negative MLR between HL-A non-identical individuals. On the other hand, a positive MLR between HL-A identical sibs has been described [3,4, 24-26, 331.…”

Section: Discussionmentioning

confidence: 77%

HL‐A Typing in Families of Potential Kidney Recipients

et al. 1973

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Abstract. HL‐A typing was performed in 22 potential kidney recipients, 35 parents and 87 siblings. Homozygosity for one or two HL‐A antigens was present in about half of the patients with a phenotypic incomplete HL‐A pattern. In 12 patients 23 HL‐A identical siblings were found. In one patient recombination of the paternal first and second locus of the HL‐A system was observed. Mixed lymphocyte reactions (MLR) were carried out with 3 sibs and an unrelated donor. A difference at the first HL‐A locus was accompanied by a weak mixed lymphocyte reactivity, while a difference at the second HL‐A locus gave rise to a strong MLR. Our findings support the hypothesis of two MLR loci localized closely to the HL‐A loci.

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The Hl-a System and the Mixed Lymphocyte Reaction

Cited by 9 publications

References 3 publications

An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

HL-A Typing in Families of Potential Kidney Recipients

HL‐A Typing in Families of Potential Kidney Recipients

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