An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

Keuning, J.J.; Tweel, Jan G. van den; Gabb, B. W.; Termijtelen, A.; Goulmy, Els; Bloxland, E.; Elferink, B. G.; ROOl, J. J.

doi:10.1111/j.1399-0039.1975.tb00623.x

Cited by 23 publications

(6 citation statements)

References 18 publications

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“…The observation that sibs which are identical for two independent LD specificities never stimulate each other in MLR, while sibs, which differ for one or two LD specificities, always do, even in the event of a recombination between the SD and LD loci ( Table 2), strongly suggests that by LD typing, one types for structures that determine the outcome of the MLR. The recombination frequency between the SD and LD loci of 0.007 in the dog is similar to the recombination frequency in man (0.007 Keuning et al 1975b, 0.009 Netzel et al 1975). These calculations are based on the assumption that only one major MLR locus exists.…”

Section: Discussionsupporting

confidence: 55%

Polygenic Control of Mixed Lymphocyte Reactions in Dogs

et al. 1977

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The genetics of the MLR of the dog are studied using LD typing cells. The four new homozygous reference cells described bring the total number of defined LD specificities in this species to 11. In families, LD specificities generally segregate en bloc with the SD specificities of the DLA complex. The recombination frequency between the SD and LD loci is provisionally estimated to be 0.007. A slight but significant stimulation between two SD identical LD typed siblings could not be explained on the basis of a single recombination between the SD loci and one LD locus and therefore suggested the existence of an additional LD system. Unrelated SD different individuals with two different LD determinants in common frequently stimulate each other in MLR, but low responses are also encountered. The results described are compatible with a hypothesis of two segregant series of alleles for the genetic control of the MLR and linkage disequilibrium between certain alleles of these series. More conclusive evidence of the validity of this hypothesis and further knowledge of other factors which determine the response in the MLR are required before a reliable estimate of the importance of LD structures in histocompatibility can be made.

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Section: Discussionsupporting

confidence: 55%

Polygenic Control of Mixed Lymphocyte Reactions in Dogs

et al. 1977

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“…Two crossings-over between A and B loci in 192 informative meioses and none between B and D loci in 129 meioses are essentially the same as those found normally (Belvedere e t al. 1975, Keuning et al 1975.…”

Section: Discussionmentioning

confidence: 99%

HLA Genetics of Insulin‐Dependent Juvenile‐Onset Diabetes Mellitus in Northern Finland

et al. 1980

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HLA‐A, B and C antigens were determined from 63 cases of juvenile‐onset, insulin‐dependent diabetes mellitus (IDDM) in northern Finland. There was a very strong association between IDDM and HLA‐B8 and B15 antigens in this area where the incidence of IDDM is also high. Relative risks for B8 and B15 were 4.8 and 3.8, respectively. In a small group of subjects typed for HLA‐D antigens Dw3 and Dw4 appeared to be stronger risk factors than associated B antigens, whereas Dw2 was almost totally absent in the patients.

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“…Of these four, only one was counted as B, D recombinant (Netzel et al 1975). Likewise, one family from the Leyden series (Keuning et al 1975) and two families from the Seattle study (Mickelson et al 1976) were excluded because they gave uninterpretable MLC results which could not be clarified. If all these excluded cases are counted as recombinants the estimates from these series move into the range 1.1 -1.3 centiMorgans.…”

Section: Discuss;onmentioning

confidence: 99%

“…In two of the studies (Keunhg et al 1975, Mickelson et al 1976) this is remedied by reducing the number of informative families with a factor calculated as the probability of homozygosity at the B locus. Furthermore, Keuning et al (1975) took the calculated probability of D-locus homozygosity into account. It is difficult to appreciate the effectiveness of these corrections, especially when the marked linkage disequilibrium between D and B alleles is remembered.…”

Section: Discuss;onmentioning

confidence: 99%