1975
DOI: 10.1111/j.1399-0039.1975.tb00623.x
|View full text |Cite
|
Sign up to set email alerts
|

An Estimation of the Recombination Fraction between the MLC Locus and the FOUR Locus

Abstract: Thirty‐nine families with 167 children were typed for HL‐A and studied in the MLC test. Two maternal recombinations between the FOUR and the MLC locus in two different families were found. An estimate of the recombination fraction between the FOUR and the MLC locus was calculated.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

1
5
0

Year Published

1976
1976
2019
2019

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 23 publications
(6 citation statements)
references
References 18 publications
1
5
0
Order By: Relevance
“…The observation that sibs which are identical for two independent LD specificities never stimulate each other in MLR, while sibs, which differ for one or two LD specificities, always do, even in the event of a recombination between the SD and LD loci ( Table 2), strongly suggests that by LD typing, one types for structures that determine the outcome of the MLR. The recombination frequency between the SD and LD loci of 0.007 in the dog is similar to the recombination frequency in man (0.007 Keuning et al 1975b, 0.009 Netzel et al 1975). These calculations are based on the assumption that only one major MLR locus exists.…”
Section: Discussionsupporting
confidence: 55%
“…The observation that sibs which are identical for two independent LD specificities never stimulate each other in MLR, while sibs, which differ for one or two LD specificities, always do, even in the event of a recombination between the SD and LD loci ( Table 2), strongly suggests that by LD typing, one types for structures that determine the outcome of the MLR. The recombination frequency between the SD and LD loci of 0.007 in the dog is similar to the recombination frequency in man (0.007 Keuning et al 1975b, 0.009 Netzel et al 1975). These calculations are based on the assumption that only one major MLR locus exists.…”
Section: Discussionsupporting
confidence: 55%
“…Two crossings-over between A and B loci in 192 informative meioses and none between B and D loci in 129 meioses are essentially the same as those found normally (Belvedere e t al. 1975, Keuning et al 1975.…”
Section: Discussionmentioning
confidence: 99%
“…Of these four, only one was counted as B, D recombinant (Netzel et al 1975). Likewise, one family from the Leyden series (Keuning et al 1975) and two families from the Seattle study (Mickelson et al 1976) were excluded because they gave uninterpretable MLC results which could not be clarified. If all these excluded cases are counted as recombinants the estimates from these series move into the range 1.1 -1.3 centiMorgans.…”
Section: Discuss;onmentioning
confidence: 99%
“…In two of the studies (Keunhg et al 1975, Mickelson et al 1976) this is remedied by reducing the number of informative families with a factor calculated as the probability of homozygosity at the B locus. Furthermore, Keuning et al (1975) took the calculated probability of D-locus homozygosity into account. It is difficult to appreciate the effectiveness of these corrections, especially when the marked linkage disequilibrium between D and B alleles is remembered.…”
Section: Discuss;onmentioning
confidence: 99%
See 1 more Smart Citation