1977
DOI: 10.1111/j.1399-0039.1977.tb01106.x
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Polygenic Control of Mixed Lymphocyte Reactions in Dogs

Abstract: The genetics of the MLR of the dog are studied using LD typing cells. The four new homozygous reference cells described bring the total number of defined LD specificities in this species to 11. In families, LD specificities generally segregate en bloc with the SD specificities of the DLA complex. The recombination frequency between the SD and LD loci is provisionally estimated to be 0.007. A slight but significant stimulation between two SD identical LD typed siblings could not be explained on the basis of a s… Show more

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Cited by 11 publications
(4 citation statements)
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“…The positive reactions found on secondary culture of cells stimulated with lymphocytes that do not share the sensitizing DLA-LD determinants with the primary stimulator indicate that genetic factors different from LD must be involved. A considerable number of observations argue against the genetic control of mixed lymphocyte reactions in dogs by only one locus (Bijnen et al 1977(Bijnen et al , 1979. The one LD locus model used in this paper is therefore probably an oversimplification.…”
Section: Discussionmentioning
confidence: 93%
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“…The positive reactions found on secondary culture of cells stimulated with lymphocytes that do not share the sensitizing DLA-LD determinants with the primary stimulator indicate that genetic factors different from LD must be involved. A considerable number of observations argue against the genetic control of mixed lymphocyte reactions in dogs by only one locus (Bijnen et al 1977(Bijnen et al , 1979. The one LD locus model used in this paper is therefore probably an oversimplification.…”
Section: Discussionmentioning
confidence: 93%
“…Gene products of an additional LD locus (or loci) could be t h e cause of the positive reactions against cells not sharing any known LD allele with the primary stimulator. Such a locus (or loci) may be located within (Grosse-Wilde et al 1975, Bijnen et al 1977, Fuller et al 1978 or without the MHC (Nunez-Rodan e t al. 1978, Singd 1978.…”
Section: Discussionmentioning
confidence: 99%
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