Minor Histocompatibility Systems in Dogs

History of graft-versus-host disease

“…The immunologic identification of MiHC antigens is difficult because the rejection of an MiHC graft does not lead to the production of antibodies, tissue-typing reagents, recognizing MiHC antigens. Most, if not all, mammalian species have a monomorphic MiHC on the Y chromosome and a polymorphic MiHC on the X chromosome [32].…”