1980
DOI: 10.1007/978-3-642-67319-1_30
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Role of Total Body Irradiation in Conditioning for Bone Marrow Transplantation

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Cited by 24 publications
(9 citation statements)
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“…However, the extrapolated No was significantly lower than the most reliable estimates for the total number of rhesus monkey bone marrow cells, on which basis we had to assume that in the lower dose range of 1 to 5 Gy , hemopoietic reconstitution is mainly derived from a more radiosensitive cell type. In fact, such a cell type is perfectly in agreement with the LD50 for the untreated bone marrow syndrome and the Do value of 0.5-0.75 Gy reported earlier [3], which was indeed based on observations in the lower dose range of 1 to 5 Gy, and is also in agreement with the mouse studies summarized below. We concluded that, even following doses of TBI which approach lethality due to gastrointestinal damage, sufficient hemopoietic stem cells survived for ultimate hemopoietic reconstitution, be it at the expense of a prolonged period of profound pancytopenia in addition to longstanding immunodeficiency.…”
Section: $50010supporting
confidence: 92%
See 1 more Smart Citation
“…However, the extrapolated No was significantly lower than the most reliable estimates for the total number of rhesus monkey bone marrow cells, on which basis we had to assume that in the lower dose range of 1 to 5 Gy , hemopoietic reconstitution is mainly derived from a more radiosensitive cell type. In fact, such a cell type is perfectly in agreement with the LD50 for the untreated bone marrow syndrome and the Do value of 0.5-0.75 Gy reported earlier [3], which was indeed based on observations in the lower dose range of 1 to 5 Gy, and is also in agreement with the mouse studies summarized below. We concluded that, even following doses of TBI which approach lethality due to gastrointestinal damage, sufficient hemopoietic stem cells survived for ultimate hemopoietic reconstitution, be it at the expense of a prolonged period of profound pancytopenia in addition to longstanding immunodeficiency.…”
Section: $50010supporting
confidence: 92%
“…Vriesendorp and Van Bekkum [3] arrived at Do values between 0.5 and 0.7 .5 Gy. Although this approach may still be valid to characterize the radiation sensitivity of hemopoietic cells required for rescue from radiation-induced bone marrow failure in an untreated patient, more recent evidence has accumulated to demonstrate that the heterogeneity of immature hemopoietic cells is also reflected by a heterogeneity in radiation sensitivity with practical consequences for the treatment of radiation accident victims.…”
mentioning
confidence: 96%
“…14,27 Unfortunately, this strategy cannot be applied to humans due to the limited number of hematopoietic cells that can be harvested using the current clinically available procedures. It is widely accepted that myeloablation facilitates engraftment of fresh and/or transduced syngeneic hematopoietic cells in most transplantation models, [30][31][32][33][34] and that ex vivo transduction of the graft impairs the repopulating ability of the graft. However, whether there is a threshold level of engraftment of transduced cells for tolerance induction still needs to be elucidated.…”
Section: In the Bm Of The Recipient Mice 5 Months After Transplanmentioning
confidence: 99%
“…The LD50 for TBI of dogs is lower than in most other experimental animals. A model explaining this result has been presented in a previous paper (Vriesendorp & van Bekkum 1980a). The LD50 for the GI syndrome in dogs is lower than that in rodents and rhesus monkeys.…”
Section: Discussionmentioning
confidence: 71%
“…The optimal BM cell number is the one that guarantees a timely reoccurrence of hemopoietic end cells and does not increase the risks of GvHD. Extrapolations from animal studies suggest that for humans this number is approximately 2 x 1O8.kg-' (Vriesendorp et al 1980a).…”
Section: Discussionmentioning
confidence: 98%