HL‐A Typing in Families of Potential Kidney Recipients

Abstract

Abstract. HL‐A typing was performed in 22 potential kidney recipients, 35 parents and 87 siblings. Homozygosity for one or two HL‐A antigens was present in about half of the patients with a phenotypic incomplete HL‐A pattern. In 12 patients 23 HL‐A identical siblings were found. In one patient recombination of the paternal first and second locus of the HL‐A system was observed. Mixed lymphocyte reactions (MLR) were carried out with 3 sibs and an unrelated donor. A difference at the first HL‐A locus was accompanied by a weak mixed lymphocyte reactivity, while a difference at the second HL‐A locus gave rise to a strong MLR. Our findings support the hypothesis of two MLR loci localized closely to the HL‐A loci.

A Crossover in the HL‐A System Traced through Three Generations

“…Study of MCL reactivity of this family was not possible due to the wide geographical distances separating the members of the family. Mills 1974, Blumenthal et al 1974, Yunis et al 1974, Sybesma et al 1973 Seigler 1973, Gatti et al 1971, Mayr & Mickerts 1971, Svejgaard et al 1971). These reports are of value in the delineation of the size of the HL-A system, and in the study of allelism and linkage.…”