The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients

ELDerawi, Wafaa A.; Naser, Ihab A.; Taleb, Mahmmoud H.; Abutair, Ayman S.

doi:10.3390/nu11010044

Cited by 51 publications

(58 citation statements)

References 24 publications

(29 reference statements)

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“…In the present study, despite a significant reduction in insulin concentrations, HbA1c levels and HOMA-IR, we did not find any significant effect on FPG following Mg supplementation. Consistent with our findings, in a study conducted by ELDerawi et al ( 62 ) , Mg supplementation (250 mg/d of elemental Mg) for 3 months to patients with T2DM significantly reduced insulin, HbA1c levels and HOMA-IR but did not affect fasting glucose. Moreover, Yokota et al ( 63 ) reported a significant reduction in insulin levels and HOMA-IR but not in fasting glucose and HbA1c after Mg supplementation for 30 d in patients with T2DM.…”

Section: Discussionsupporting

confidence: 92%

Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

et al. 2019

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This study evaluated the effects of Mg administration on carotid intima–media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=–9·42 pmol/l; 95% CI –14·94, –3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=–0·56; 95 % CI –0·89, –0·24; P=0·001) and HbA1c (β=–0·74 %; 95 % CI –1·10, –0·39; P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=–0·30 mmol/l; 95% CI –0·56, –0·04; P=0·02), LDL-cholesterol (β=–0·29 mmol/l; 95% CI –0·52, –0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.

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Section: Discussionsupporting

confidence: 92%

Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

et al. 2019

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“…A continuous infusion of magnesium sulfate at 15 mg/kg/h produces a better-controlled effect on blood glucose level in patients with diabetes mellitus undergoing cardiac surgery ( Soliman and Nofal, 2019 ). Oral magnesium supplementation (jamieson magnesium tablet, containing 250 mg elemental magnesium) daily for 3 months reduces insulin resistance and improves glycemic control indicators among type 2 diabetes patients ( Elderawi et al, 2018 ).…”

Section: Therapeutic Application Of Magnesium In Other Diseasesmentioning

confidence: 99%

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.

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“…In contrast, another substance, magnesium, was suggested to decrease the risk of cardiovascular diseases in T2D patients. Magnesium deficiency was associated with diabetes risk, whereas magnesium supplementation could attenuate insulin resistance and improve glycemic control in T2D patients (Wa et al, 2018).…”

Section: Mineral Substancesmentioning

confidence: 99%

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Guo

Huang

Sang

et al. 2020

Front. Bioeng. Biotechnol.

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Type 2 diabetes (T2D) is a rapidly growing epidemic, which leads to increased mortality rates and health care costs. Nutrients (namely, carbohydrates, fat, protein, mineral substances, and vitamin), sensing, and management are central to metabolic homeostasis, therefore presenting a leading factor contributing to T2D. Understanding the comprehensive effects and the underlying mechanisms of nutrition in regulating glucose metabolism and the interactions of diet with genetics, epigenetics, and gut microbiota is helpful for developing new strategies to prevent and treat T2D. In this review, we discuss different mechanistic pathways contributing to T2D and then summarize the current researches concerning associations between different nutrients intake and glucose homeostasis. We also explore the possible relationship between nutrients and genetic background, epigenetics, and metagenomics in terms of the susceptibility and treatment of T2D. For the specificity of individual, precision nutrition depends on the person's genotype, and microbiota is vital to the prevention and intervention of T2D.

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The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients

Cited by 51 publications

References 24 publications

Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

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