Background: Magnesium (Mg) supplementation may help control glycemic response among type 2 diabetes (T2D) patients. Objective: This study means to determine whether Mg supplementation improves glycemic control indicators in patients with T2D. Methods: After one week of the dietary stabilization phase, 42 T2D patients were stratified according to sex, age, fasting blood sugar (FBS) and Mg levels and then randomly allocated into two groups. The intervention group was on 250 mg/day of elemental Mg for three months while the control group did not receive any type of supplements throughout the intervention period. Results: The daily administration of 250 mg of elemental Mg indicated a significant improvement in HbA1C (8.32 to 7.96%, p < 0.001), insulin levels (IL) (15.56 to 12.18 μIU/mL, p < 0.001), C-peptide (2.28 to 1.90 ng/mL, p = 0.001), HOMA.IR (6.16 to 4.44, p < 0.001) and HOMA.β% (59.99 to 52.37, p = 0.036) of the intervention group when compared with the control group after three months of intervention. Conclusion: The results of this study revealed that oral Mg supplementation reduces insulin resistance and improves the glycemic control indicators among T2D patients. Trial registration: current controlled trials PHRC/HC/32/15. Registered 5 October 2015.
The Effect of Atorvastatin on Liver Function among Patients with Coronary Heart Disease in Gaza Strip Mahmmoud H. Taleb1*, Ihab M. Almasri2, Naima I. Siam3, Ahmed A. Najim4, Adham I. Ahmed4 1Department of Pharmacology, Al-Azhar University, Gaza, Palestine 2Department of Pharmaceutical Chemistry, Al-Azhar University, Gaza, Palestine 3Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine 4Faculty of Intermediate Studies, University of Palestine, Gaza, Palestine Email: *mahtaleb@hotmail.com Received 16 April 2014; revised 2 June 2014; accepted 27 June 2014 Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/Statins, which are inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are considered as one of the most important drugs and the drug of choice for reducing an abnormal cholesterol level. Statins are normally used to decrease the risk of coronary heart disease (CHD), but they tend to be associated with liver adverse effects. The objective of this prospective study was to investigate the effect of atorvastatin therapy on the liver function in patients with CHD. Study comprised of 66 newly diagnosed CHD patients who were selected from UNRWA clinics in the Gaza Strip. The patients were clinically examined and treated with atorvastatin (10 - 40 mg/day). A questionnaire was used to collect the data concerning patient’s characteristics. Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), liver enzymes tests such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and total and direct blood bilirubin were measured before starting treatment and after 3 and 6 months of treatment. The results showed a significant increase in the mean values of ALT, AST, total bilirubin and direct bilirubin levels after 3 months then decreased after the next 3 months, but they were higher than the baseline with insignificant association
Burn is a traumatic injury that causes immunological, endocrine, inflammatory, many metabolic responses and emotional stress which can affect dietary, micronutrients and antioxidants intake, which in turn have effects on recovery outcomes. To investigate the role of the nutrition and dietary intake on the progression of the different stages of the healing process among burned patients in Gaza strip. One hundred burned adult patients (36males and 64 females) were enrolled in this cross-sectional clinic-based study at Médecins Sans Frontières/ France clinics in Gaza Strip. Pretested interview questionnaires, Food Frequency Questionnaires, 24 hour dietary recall, anthropometric measures, and biochemical tests were used to assess dietary, health, and healing score among burned patients. This study reported positive association between Magnesium (χ2=8.700, p=0.013), Copper (χ2=60.916, p=<0.0001), and Vitamin C (χ2=91.684, p=<0.0001)) with healing score. The results reported that the protein and energy intake were significantly lower (< 0.001) than the recommendations for both components, which might explain the higher prevalence of moderate healing (65%) among the participants. The adequacy of micronutrients such as Magnesium, Copper, and Vitamin C might be associated with positive wound healing outcomes. Consumption of healthy food is very important for healing process among burned patients. There is a real need for planned and well-balanced meals for burned patients.
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