Background: Magnesium (Mg) supplementation may help control glycemic response among type 2 diabetes (T2D) patients. Objective: This study means to determine whether Mg supplementation improves glycemic control indicators in patients with T2D. Methods: After one week of the dietary stabilization phase, 42 T2D patients were stratified according to sex, age, fasting blood sugar (FBS) and Mg levels and then randomly allocated into two groups. The intervention group was on 250 mg/day of elemental Mg for three months while the control group did not receive any type of supplements throughout the intervention period. Results: The daily administration of 250 mg of elemental Mg indicated a significant improvement in HbA1C (8.32 to 7.96%, p < 0.001), insulin levels (IL) (15.56 to 12.18 μIU/mL, p < 0.001), C-peptide (2.28 to 1.90 ng/mL, p = 0.001), HOMA.IR (6.16 to 4.44, p < 0.001) and HOMA.β% (59.99 to 52.37, p = 0.036) of the intervention group when compared with the control group after three months of intervention. Conclusion: The results of this study revealed that oral Mg supplementation reduces insulin resistance and improves the glycemic control indicators among T2D patients. Trial registration: current controlled trials PHRC/HC/32/15. Registered 5 October 2015.
Background: The intake of dietary fiber has been shown to impair the absorption of minerals and trace elements in the small intestine because of their binding and/or sequestering effects. Objective: This study aimed to investigate the effect of water soluble fiber supplementation from psyllium on magnesium level among type 2 diabetes patients. Method: Forty Type 2 diabetes patients, non-smokers, aged ˃35 years were stratified and simply randomized into two groups; the intervention group, which consists of 20, who were given 10.5 grams of dietary fibers daily, and the control group. Which consist of 20 participants who continued on their regular diet for eight week duration. Results: After 8 weeks of soluble fiber supplementation, the study showed remarkable and significant reduction in the (FBS) before and after the intervention in the intervention group (163.11 to 116.56 mg/dL), while in the control group, a minor reduction in the fasting blood sugar was reported (156.39 to 151.22 mg/dL). The results did not report any significant changes in the magnesium levels at the end of the intervention program between the two groups (p = 0.580), when Repeated Measure ANOVA was used. Conclusion: The inclusion of moderate amounts of psyllium to the normal daily diet is safe and dose not decrease magnesium level in the plasma among type 2 diabetes patients.
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