The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

Ding, Yuanlin; Fu, Xiaodi; Liu, Huiyang; Wang, Honggang; Wu, Dongdong

doi:10.3390/ijms222312766

Cited by 11 publications

(10 citation statements)

References 76 publications

(81 reference statements)

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“…E2-induced NLRP3 inflammasome promoted HCC via upregulating caspase-1-dependent pyroptosis of HCC cells ( Wei et al, 2019 ). The interaction between NLRP3 inflammasome and autophagy participates in many pathological processes ( Tao et al, 2020 ; Ding et al, 2021 ; Lv et al, 2021 ). In the above study, autophagy inhibition promotes E2-induced NLRP3 inflammasome of HCC cells, thus providing a new idea for HCC treatment by regulating autophagy.…”

Section: Nlrp3 Inflammasome-mediated Pyroptosis Plays a Protective Ro...mentioning

confidence: 99%

“…The activated caspase-1 cleaved pro-IL-1β and pro-IL-18 into their active forms. The N-terminal domain of cleaved GSDMD drills pores in the cell membrane and promotes the release of IL-1β and IL-18, thus inducing pyroptosis ( Figure 1 ) ( Ding et al, 2021 ; Coll et al, 2022 ). The evidences indicate that NLRP3 inflammasome is closely related to the tumorigenesis, including proliferation, invasion, angiogenesis and metastasis ( Moossavi et al, 2018 ; Ershaid et al, 2019 ; Sharma and Kanneganti, 2021 ), however, the relevant mechanisms are not completely clear.…”

Section: Introductionmentioning

confidence: 99%

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The role of NLRP3 inflammasome in hepatocellular carcinoma

Zhao

Zhang

et al. 2023

Front. Pharmacol.

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Inflammasomes play an important role in innate immunity. As a signal platform, they deal with the excessive pathogenic products and cellular products related to stress and injury. So far, the best studied and most characteristic inflammasome is the NLR-family pyrin domain-containing protein 3(NLRP3) inflammasome, which is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. The formation of NLRP3 inflammasome complexes results in the activation of caspase-1, the maturation of interleukin (IL)-1β and IL-18, and pyroptosis. Many studies have demonstrated that NLRP3 inflammasome not only participates in tumorigenesis, but also plays a protective role in some cancers. Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Currently, due to the lack of effective treatment methods for HCC, the therapeutic effect of HCC has not been ideal. Therefore, it is particularly urgent to explore the pathogenesis of HCC and find its effective treatment methods. The increasing evidences indicate that NLRP3 inflammasome plays a vital role in HCC, however, the related mechanisms are not fully understood. Hence, we focused on the recent progress about the role of NLRP3 inflammasome in HCC, and analyzed the relevant mechanisms in detail to provide reference for the future in-depth researches.

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Section: Nlrp3 Inflammasome-mediated Pyroptosis Plays a Protective Ro...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of NLRP3 inflammasome in hepatocellular carcinoma

Zhao

Zhang

et al. 2023

Front. Pharmacol.

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“…NF-κB signaling pathway downregulation also promotes autophagic activity. Enhanced autophagy is typically accompanied by reduced inflammasome formation [43] . Activation of autophagy including mitophagy cleans the inflammatory debris and accelerates tissue recovery from inflammation and this has often observed in melatonin-treated animals [44] , [45] .…”

Section: Melatonin Targets Host: Downregulating the Overreaction Of I...mentioning

confidence: 99%

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

Tan

Reíter

2022

Life Sciences

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“…Autophagy is a cellular mechanism that has been conserved throughout evolution and is crucial for the survival and upkeep of cells by destroying organelles, proteins, and macromolecules (Ding et al 2021). Pro-IL-1β, mitochondria, and the inflammasome components are all degraded by autophagosomes, which reduces IL-1β release (Levine and Deretic 2007).…”

Section: Introductionmentioning

confidence: 99%

Auranofin attenuates Schistosoma mansoni egg-induced liver granuloma and fibrosis in mice

Atia,

Abou-Hussien,

Sweed

et al. 2023

J. Helminthol.

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Schistosomiasis is a serious tropical disease. Despite extensive research into the etiology of liver fibrosis, effective therapeutic options remain limited. This study aims to assess the effectiveness of auranofin in treating hepatic granuloma and fibrogenesis produced by Schistosoma (S.) mansoni eggs. Auranofin is a gold complex that contains thioglucose tetraacetate and triethylphosphine. Eighty BALB/c male mice were divided into four groups (n=20/group): negative control (GI), positive control (GII), and early (GIII) and late (GIV) treatment groups with oral auranofin according to beginning of treatment 4th week and 6th week post-infection. Mice were infected subcutaneously in a dose of 60±10 cercariae/mouse. Worm counts, egg loads, and oogram patterns were determined. Biochemical, histological, and immunostaining of interleukin-1β (IL-1β), Sirtuin 3 (SIRT3), and smooth muscle actin (SMA) were assessed. GIII showed a significant decrease in the total S. mansoni worm burden and ova/gram in liver tissue (with reduction percent of 63.07% and 78.26%, respectively). Schistosomal oogram patterns, immature and mature ova, also showed a significant decrease. The reduction in granuloma number and size was 40.63% and 48.66%, respectively, in GIII, whereas in GIV, the reduction percent was 76.63% and 67.08%. In addition, the degree of fibrosis was significantly diminished in both treated groups. GIV showed significant reduction in IL-1β and SMA expression and increase in SIRT3 expression. These findings reveal how auranofin suppresses the development of liver fibrosis. Therefore, it is crucial to take another look at auranofin as a prospective medication for the treatment of S. mansoni egg-induced hepatic granuloma and consequent fibrosis.

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The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

Cited by 11 publications

References 76 publications

The role of NLRP3 inflammasome in hepatocellular carcinoma

The role of NLRP3 inflammasome in hepatocellular carcinoma

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

Auranofin attenuates Schistosoma mansoni egg-induced liver granuloma and fibrosis in mice

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