Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

Tan, Dun‐Xian; Reíter, Russel J.

doi:10.1016/j.lfs.2022.120368

Cited by 17 publications

(34 citation statements)

References 104 publications

(113 reference statements)

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“…During the current pandemic, melatonin has been widely reported as being a potential therapeutic option against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred to as COVID-19 [23][24][25]. The rationale for using melatonin against this condition stems from the elevated oxidative activity and production of ROS and RNS observed in patients with COVID-19 [26,27].…”

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confidence: 99%

Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

2022

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Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

2022

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“…The combination of melatonin with conventional therapies may substantially reduce the mortality of severely ill COVID-19 patients. The main target of melatonin is the immune system; thus, it has a protective action against gene-mutated variants [ 143 ]. Moreover, melatonin does not act as a virucidal but shows indirect antiviral action by reducing inflammation, oxidation, and enhancing immune features.…”

Section: Nutraceuticals and Dietary Supplements Against Covid-19 Dise...mentioning

confidence: 99%

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano

Iacopetta

Ceramella

et al. 2022

Foods

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The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The reduction of severe cases and deaths from COVID-19 led to increasing importance of a new disease called post-COVID syndrome. The term post-COVID is used to indicate permanency of symptoms in patients who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well as ozone therapy have been used to treat COVID-19 disease. Vaccines have then become available and administered worldwide to prevent the insurgence of the disease. However, the pandemic is not over yet at all given the emergence of new omicron variants. New therapeutic strategies are urgently needed. In this view, great interest was found in nutraceutical products, including vitamins (C, D, and E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), and curcumin. This review summarizes the role of nutraceuticals in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.

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“…It may be possible to prevent the development of severe disease symptoms in patients with COVID-19 and reduce the immuno-pathology of SARS-CoV-2 infection after the active phase of the infection is over by utilizing melatonin [ 142 ]. A few trials have already demonstrated the benefits of melatonin in COVID-19 [ 143 ]. Additional experiments and clinical studies need to be conducted to confirm this speculation.…”

Section: Cell Membrane and Golgi Apparatusmentioning

confidence: 99%

Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview

Gorący

Rosik

Szostak

et al. 2022

Viruses

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Since the end of 2019, the whole world has been struggling with the life-threatening pandemic amongst all age groups and geographic areas caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). The Coronavirus Disease 2019 (COVID-19) pandemic, which has led to more than 468 million cases and over 6 million deaths reported worldwide (as of 20 March 2022), is one of the greatest threats to human health in history. Meanwhile, the lack of specific and irresistible treatment modalities provoked concentrated efforts in scientists around the world. Various mechanisms of cell entry and cellular dysfunction were initially proclaimed. Especially, mitochondria and cell membrane are crucial for the course of infection. The SARS-CoV-2 invasion depends on angiotensin converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and cluster of differentiation 147 (CD147), expressed on host cells. Moreover, in this narrative review, we aim to discuss other cell organelles targeted by SARS-CoV-2. Lastly, we briefly summarize the studies on various drugs.

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Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

Cited by 17 publications

References 104 publications

Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview

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