The association of cholesteryl ester transfer protein polymorphism with high‐density lipoprotein cholesterol and coronary artery disease in Koreans

Abstract

Cholesteryl ester transfer protein (CETP) is a key protein involved in high-density lipoprotein cholesterol (HDL-C) metabolism. It is known to affect plasma HDL-C levels, and its genetic regulation may be involved in the development of coronary artery disease (CAD). The aim of this study was to determine the frequency of the CETP Taq1B polymorphism in Koreans, and to investigate its relationship with plasma HDL-C levels and CAD. One-hundred and nineteen patients with significant CAD and 106 controls were examined with respect to their genotypes, lipid profiles and other risk factors of CAD. The genotype frequencies of B1B1:B1B2:B2B2 in males and females were 35.5%:50%:14.5% and 34.7%:42.6%:22.7%, respectively, which is comparable to previous reports in other ethnic groups. The B1B1 homozygote was associated with significantly lower HDL-C levels in females (p = 0.049) and non-smoking males (p = 0.037). After controlling for gender, body mass index (BMI) and smoking, the TaqIB polymorphism was still significantly associated with HDL-C levels (p = 0.046) and explained 5.4% of the HDL-C variation in this study. By univariate analysis, the B1B1 homozygote was a significant predictor of CAD (p = 0.043), and this was confirmed by multivariate analysis with traditional risk factors, i.e. the B1B1 homozygote was an independent predictor of CAD (p = 0.026, odds ratio = 1.97, 95% confidence interval: 1.08-3.57). In conclusion, the B1B1 homozygote of the CETP Taq1B polymorphism is associated with low HDL-C levels in females and non-smoking males, and may be an independent genetic risk factor of CAD in the Korean population.

Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease

“…The less-common allele of this SNP has been shown to be associated with lower CETP and higher HDL levels across numerous studies and populations with highly significant P values (45,49,53,60,. Only in studies with small test populations has neither CETP nor HDL been affected in a statistically significant manner (43,(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). Since it is not immediately apparent how this SNP could modulate CETP expression, it has long been suspected that this SNP is linked with another change that more directly affects expression.…”

Human Cholestryl Ester Transfer Protein (TaqIB) Polymorphism among Filipinos with Cardiovascular Risk Factors

“…Included among these gene products is CETP 25) . The different studies cited 20,21,25) have shown the association of B1B1 and B2B2 with low and high HDL-cholesterol respectively and the presence of CAD. Our study did not look for the association of each TaqIB polymorphism with a cardiovascular event.…”

“…In the Framingham Offspring Study 20) , they reported B1B1 (30%), B1B2 (51%) and B2B2 (19%). Park and Choi 21) , in their Korean cohorts discovered that their genotype frequencies of B1B1: B1B2: B2B2 in males and females were 35.5%: 50%: 14.5% and 34.7%: 42.6%: 22.7%, respectively. In our study, note that we have higher frequency of B1B1 and lower frequency of B2B2 but similar frequency of B1B2 comparing it with the different studies.…”

“…Only few studies has reported about CETP Polymorphisms and its relation with HDL-C among Asians. In Korea, Park and Choi reported that B1B1 homozygote of the CETP TaqIB polymorphism is associated with low HDL-C levels in females and non-smoking males, and may be an independent genetic risk factor of CAD in the Korean population 21) . In the Philippines, no study has been conducted yet to investigate the frequency of CETP Polymorphism and its association with HDL cholesterol levels among Filipinos particularly those with cardiovascular risk factors.…”

Relationship of polymorphisms in the cholesteryl ester transport protein gene R451Q with coronary heart disease and diabetes in Uyghur and Han Chinese

“…Studies have shown that the CETP gene determines levels of HDL-C, and that it is an independent risk factor for AS and cardiovascular disease (Park et al, 2003;Spielmann et al, 2007;McCaskie et al, 2007;Kathiresan et al, 2009;Papp et al, 2012;Khovidhunkit et al, 2012). The relationships of gene polymorphisms in CETP with coronary heart disease (CHD), blood lipids, and lipoproteins and apolipoproteins have been extensively studied, but were found to be inconsistent (Boekholdt and Thompson, 2003).…”