Human Cholestryl Ester Transfer Protein (TaqIB) Polymorphism among Filipinos with Cardiovascular Risk Factors

Sy, Rody G.; Cutiongco, Eva Maria; Punzalan, Felix Eduardo R.; Santos, Ronald S.; Geronimo, Francis Ruel B; Tangco, Rogelio V.

doi:10.5551/jat.14.116

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…With the identification of these polymorphisms, causes of low HDL‐C other than the traditional causes among Filipinos have been established (Sy et al. ).…”

Section: Availability Of Genetic Servicesmentioning

confidence: 99%

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Genetics and genomic medicine in the Philippines

Padilla

Paz

2016

Mol Genet Genomic Med

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“…With the identification of these polymorphisms, causes of low HDL‐C other than the traditional causes among Filipinos have been established (Sy et al. ).…”

Section: Availability Of Genetic Servicesmentioning

confidence: 99%

“…Additionally, B1B1 is found to be associated with low HDL-C levels. With the identification of these polymorphisms, causes of low HDL-C other than the traditional causes among Filipinos have been established (Sy et al 2007).…”

Section: Molecular Geneticsmentioning

confidence: 99%

Genetics and genomic medicine in the Philippines

Padilla

Paz

2016

Mol Genet Genomic Med

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“…17,18 Among Filipinos, the CETP TaqIB polymorphism has also been implicated in HDL-c levels. 19 The hepatic uptake of atorvastatin and simvastatin is facilitated by the organic anion-transporting polypeptide 1B1 (OATP1B1), encoded by SLCO1B1. Polymorphisms in SLCO1B1 become potential targets for analyzing impact on statin lipid-lowering response, as these variants could affect OATP1B1 activity.…”

Section: Introductionmentioning

confidence: 99%

Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

et al. 2021

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Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos.Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis.Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004). Conclusion.Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.

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“…The level of high-density lipoprotein cholesterol (HDL-C) independently predicts cardiovascular disease. 1 2 3 Previous genome-wide association studies elucidated genes that may directly influence the level of HDL-C, including the gene for cholesterol ester transfer protein ( CETP , MIM 118470). 4 5 6 7 8 9 10 Specifically, previous Swiss and Korean studies show that CETP single nucleotide polymorphisms (SNPs) rs6499861, rs6499863, and rs12708980 are associated with HDL-C level.…”

Section: Introductionmentioning

confidence: 99%

Effects of Obesity and Family History of Diabetes on the Association ofCETPrs6499861 with HDL-C Level in Korean Populations

Sull

Kim

Jee

2019

J Lipid Atheroscler

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Objectives The aim of this study was to examine the associations of cholesterol ester transfer protein ( CETP ) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. Methods We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). Results We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: −2.044 mg/dL, p <0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39–2.85) compared with men (OR, 1.33; 95% CI, 1.10–1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86–12.5; p =0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m 2 , individuals with a CG/GG genotype and BMI ≥25.69 kg/m 2 had an OR (95% CI) of 2.61 (1.97–3.47). Conclusions These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.

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Human Cholestryl Ester Transfer Protein (TaqIB) Polymorphism among Filipinos with Cardiovascular Risk Factors

Cited by 11 publications

References 20 publications

Genetics and genomic medicine in the Philippines

Genetics and genomic medicine in the Philippines

Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

Effects of Obesity and Family History of Diabetes on the Association ofCETPrs6499861 with HDL-C Level in Korean Populations

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