The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

Perunović, Neda; Rakić, Mia; Nikolić, Ljubinka I.; Janković, Saša; Aleksić, Zoran; Plecas, Darko; Madianos, Phoebus N.; Čakić, Saša

doi:10.1902/jop.2015.150364

Cited by 37 publications

(36 citation statements)

References 38 publications

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“…There are numerous studies showing that markers of inflammatory response are elevated in subjects suffering from periodontitis compared with healthy ones (Bretz et al, 2005;Passoja et al, 2010;Robati, Ranjbari, Ghafourian Boroujerdnia, & Chinipardaz, 2011). In the same direction, in order to understand the effect of periodontitis in various systemic conditions, studies were conducted in specific groups presenting comorbidities (Perunovic, Rakic, Nikolic, et al, 2016;Satpathy et al, 2015;Zhu, Lin, Zheng, & Chen, 2015).…”

mentioning

confidence: 99%

Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?

Zekeridou

Mombelli

Cancela

et al. 2019

Clinical & Exp Dental Res

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In periodontitis patients, high levels of several inflammatory markers may be expressed in serum, reflecting the effect of local disease on the general health. The objective of the present analysis was to compare cytokine levels assessed in peripheral blood with those in the gingival crevicular fluid (GCF) and evaluate the impact of nonsurgical periodontal therapy on the incidence of high levels of 12 biomarkers in serum. Twenty‐four patients with chronic periodontitis (Group P) contributed with serum and GCF samples at baseline (BL) and 1 and 3 months after periodontal treatment (M1 and M3). Samples were assessed for 12 cytokines using the Bio‐Plex bead array multianalyte detection system. For each analyte, peak values were calculated as greater than the mean + 2 SD of the one found in 60 periodontally healthy participants. Significant correlations between serum and GCF values were obtained in the periodontitis group for interleukin (IL) 1ra, IL‐6, and interferon γ at BL and for macrophage inflammatory protein 1β at M3 after treatment. Periodontitis subjects were found to exhibit high peaks for several inflammatory markers in serum. The highest incidence of peaks at BL was found for interferon γ (37.5% of the periodontitis subjects). For the four biomarkers with a detection frequency of >75% at BL (IL‐1ra, IL‐8, macrophage inflammatory protein 1β, and vascular endothelial growth factor), no significant difference was observed over time for the P group or between the two groups at BL. The significant correlation found between the serum and the GCF for certain cytokines and the fact that periodontitis subjects exhibit high peaks for several inflammatory markers in serum may support the hypothesis that the inflammatory reaction due to periodontitis is not restricted to the diseased sites. Within the limitations of the study, periodontal therapy did not seem to have any significant impact on the systemic cytokine levels.

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mentioning

confidence: 99%

Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?

Zekeridou

Mombelli

Cancela

et al. 2019

Clinical & Exp Dental Res

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“…Atherosclerosis, a progressive disease of medium and large elastic and muscular arteries can lead to ischemic lesions of brain, heart or extremities and can result in thrombosis and infarction of affected vessels 4 . It is considered the primary cause of heart disease and stroke and is the underlying cause of around 50% of all deaths in western societies 15 .…”

Section: Discussionmentioning

confidence: 99%

Presence of Tannerella forsythia in patients with chronic periodontal disease and atherosclerosis

Staletovic¹,

Kannosh

Šehalić³

et al. 2020

VOJNOSANIT PREGL

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Background/Aim. Periodontal disease is an inflammatory disease that occur in the tissues surrounding the teeth in response to bacterial biofilm accumulation (dental plaque). Among others, Tannerela forsythia (Tf) was recognized as one of the most significant and specific bacterial species in periodontal pocket ("red complex" bacteria). Atherosclerosis is a progressive narrowing of arteries that may lead to occlusion, as a consequence of lipid deposition. It underlies coronary heart disease (80%), as well as myocardial and cerebral infarctions. Increasing evidence over the past decade suggests a link between periodontal disease and atherosclerosis, where Tf can enter the systemic circulation directly or indirectly, and be present in atherosclerotic blood vessels. Therefore, the aim of this study was to detect the presence of Tf in atheromatous plaques obtained from different blood vessels in patients with chronic periodontitis. Methods. Ninety patients (male 61, female 29) with periodontal disease and atherosclerosis [recruited for either carotid artery stenosis requiring endartectomy or percutaneous transluminal coronary angioplasty (PTCA)] were included in this study. Clinical periodontal examinations consisted of plaque index (PI) (according to Silness Lӧu), gingival index (GI) (according to Lӧe Silnes), sulcus bleeding index (according to Mühleman-Son) and periodontal probing depth (PPD). Presence of Tf in periodontal pockets and atherosclerotic vessels was detected using polymerase chain reaction (PCR) method with positive control Tf ATCC 43037. Results. Tf was present in subgingival plaques of 68 (75.6%) of the patients, while its presence in atheromatous plaques were registered in 42 (53.3%) of the patients. It was significantly present in coronary blood vessels (41.7%), followed by carotid arteries (35.4%) and a. abdominalis aneurism (12.5%), a. mamaria (8.5%) and a. femoralis (2.1%) while in a. iliaca Tf was not detected at all. Conclusion. The present study suggests strong relationship between periodontal inflammation and atherogenesis; therefore, it should be considered as potential risk factor for atherosclerosis. Accordingly, it would be necessary to control periodontal disease in order to reduce mortality and morbidity associated with atherosclerosis.

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“…who have concluded that the women with preterm birth compared to the women with term birth have poor periodontal status. [262728] This can be explained by the fact that periodontal disease may influence pregnancy outcome by the direct or indirect effect of periodontal pathogens on the developing fetus.…”

Section: Discussionmentioning

confidence: 99%

Influence of maternal periodontal health as a risk factor for low-birth-weight infants in Terai population of Nepal

Wazir¹,

Arora

Ghosh³

et al. 2019

J Edu Health Promot

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The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

Cited by 37 publications

References 38 publications

Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?

Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?

Presence of Tannerella forsythia in patients with chronic periodontal disease and atherosclerosis

Influence of maternal periodontal health as a risk factor for low-birth-weight infants in Terai population of Nepal

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