Synthesis, structure and biological activity of copper(II) complexes with oxolinic acid

Antibacterial and antifungal activities of some trimethoprim salts

“…Psomas et al evaluated the antifungal and antibacterial properties of cupper complexes with the oxolinic acid against several pathogenic fungi and bacteria. The results showed a decreased biological activity in comparison to the free oxolinic acid (Psomas et al, 2006). Wisell et al reported the inhibition of Enterococci in urinary tract infections with trimetoprim and folates, as the inhibitory activity of trimetoprim is heavily influenced by the presence of folates (Wisell et al, 2008).…”

“…In this connection, it should be noted that the incorporation of trimethoprim in its salt form into the composition of the invention and it can promote the absorption of trimethoprim. Alternatively, trimethoprim or its salt may be incorporated into the composition with any organic acid (e.g., lactic acid, citric acid, tartaric acid, maleic acid, malic acid, glutamic acid, aspartic acid) so that the absorption rate of trimethoprim can be increased (Psomas et al, 2006;Samuelsen et al, 2000;Innocenti et al, 2009). So, many organic acids are known for their antimicrobial activity, which is the treatment of some infectious diseases.…”

Synthesis, crystal structures and DNA-binding properties of two new mononuclear copper(II) complexes

“…Among these metal complexes, copper complexes, especially mononuclear copper complexes, are widely used as antifungal and antibacterial drugs, DNA structural probes, potential anticancer drugs, etc. [10][11][12][13]. In most of the mononuclear copper complexes, the central copper ion is coordinated to mixed-ligands, such as bpy, phen, p-methylbenzoate, oxolinic acid, etc.…”

“…In most of the mononuclear copper complexes, the central copper ion is coordinated to mixed-ligands, such as bpy, phen, p-methylbenzoate, oxolinic acid, etc. [13][14][15].…”

Synthesis, Characterization and Activity against Staphylococcus of Metal(II)‐Gatifloxacin Complexes

“…Recently, research on metal complexes of quinolones has attracted much attention due to their improved solubility in water 5 or enhanced fluorescence properties [6][7][8][9][10][11][12] and their biological activities have ever been reported in previous papers. [13][14][15][16] The interaction of metal ions with drugs is a subject in the field of inorganic chemistry and biology, 17,18 and in some cases the highest activity of a drug is associated with a metal atom. [19][20][21][22][23] The metal oxidation state, the type and number of donor atoms, as well as their relative positions within the ligand are major fac-…”