Antibacterial and antifungal activities of some trimethoprim salts

Tunalı, Yağmur; Karaca, Hülya; İşcan, Gökalp; Demirci, Fatih; Benkli, Kadriye

doi:10.1007/s00044-011-9605-5

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Similar to SMX the therapeutic efficacy of drug can be maximized by combining TMP with some organic or inorganic salts in terms of increasing solubility and plasma half life of the drug in the body. Following this trend, some recent papers reported that combination of TMP with organic/inorganic salts can significantly improve drug performance (Tunalı et al 2011).…”

Section: Introductionmentioning

confidence: 95%

“…Alternatively, TMP may be incorporated with any organic acid such as lactic acid, citric acid, tartaric acid, maleic acid, malic acid, glutamic acid and aspartic acid in order to promote absorption, the rate of absorption and to facilitate biocompatibility of TMP. According to a literature example, sulfate, citrate, lactate, tartrate, malate and maleate compounds were coupled with TMP (Tunalı et al 2011) and the conjugates were found to be more potent than the drug used alone. In this case, Tunalı et al showed the antibacterial and antifungal activities of these TMP conjugates but the effects of these compounds on mammalian cells have not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates

et al. 2018

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Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a lack of data for cytotoxic effects including nephrotoxicity, gastrointestinal toxicity, hematotoxicity, neurotoxicity and ototoxicity. The main purpose behind this study was to determine cytotoxic and genotoxic activities of trimethoprim (1), trimethoprim with maleic acid (2) and trimethoprim in conjugation with oxalic acid dihydrate (3). The cytotoxic effects of these three conjugates were elucidated by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoium bromide (MTT) assay using embryonic rat fibroblast-like cell line (F2408) and H-ras oncogene activated embryonic rat fibroblast-like cancer cell line (5RP7). Additionally, determination of genotoxic activity of these three compounds were studied by using cytokinesis blocked micronucleus assay (CBMN) in human lymphocytes. The results demonstrated that trimethoprim alone and its combination with other compounds are able to induce both cytotoxic and genotoxic damage on cultured cells (F2408, 5RP7, human lymphocytes).

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates

et al. 2018

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“…APAP is an antipyretic pain killer that has been observed to have antimicrobial properties at concentrations above therapeutic use (Zimmermann and Curtis, 2017), and observed to have growth promoting effects on microorganism at therapeutic concentrations (Carvalho et al, 2010). TMP and SMX are antibiotics that are commonly taken in combination, but exhibit antimicrobial effects independently (Reeves and Wilkinson, 1979;Hida et al, 2005;Tunali et al, 2012). GEM is a medication used to treat high blood pressure, but has been observed to increase the antimicrobial potency of some pharmaceuticals (Rudin et al, 1992;Bulatova and Darwish, 2008) and to have direct impacts on plant growth (D'Abrosca et al, 2008;Pino et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemicals of Emerging Concern in Treated Wastewater Impact Microbial Growth

McLain

Gachomo

2019

Front. Environ. Sci.

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Agriculture production in California is negatively impacted by soilborne fungi, such as Verticillium dahliae, and limited water availability for irrigation. Some regions have adapted the use of recycling wastewater, i.e., reclaimed water, to supplement the potable water supply. Wastewater purification is not fully efficient at removing all contaminants and small amounts of pharmaceutical products, known as chemicals of emerging concern (CECs), remain. Acetaminophen, trimethoprim, sulfamethoxazole and gemfibrozil are some of the most common CECs found in treated wastewater and were therefore used in this study. These CECs were evaluated for their potential to interact with microorganisms directly, or for their ability to alter the development of Verticillium wilt disease in eggplants. The microorganisms Verticillium dahliae, Fusarium oxysporum f. sp. lycopersici, Piriformospora indica, Phytopthora capsici, and Bradyrhizobium japonicum were used for in vitro growth assays in the presence of CECs. CECs induced varying responses in strains of the same fungi by promoting growth of one strain while inhibiting growth of the other. CECs influenced spore germination of V. dahliae and F. oxysporum. Greenhouse experiments in which Solanum melongena (eggplants) were inoculated with V. dahliae and irrigated with CECs were used to evaluate the impacts of these chemicals on disease development. Overall our results found that most of the organisms we tested were sensitive to the CECs. P. capsici was found to be the most sensitive microorganism, while B. japonicum growth was unaffected by the CECs at the concentrations used. The greenhouse assays results indicated that plant disease severity may be influenced by given CECs at certain stages of plant growth. Overall the results of this study indicate that the concentrations of CECs found in reclaimed water are occurring at biologically relevant concentrations.

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Similarity searching for anticandidal agents employing a repurposing approach

Rodríguez‐Villar,

Cortés‐Benítez,

Palacios‐Espinosa

et al. 2024

Molecular Informatics

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Fungal infections caused by Candida are still a public health concern. Particularly, the resistance to traditional chemotherapeutic agents is a major issue that requires efforts to develop new therapies. One of the most interesting approaches to finding new active compounds is drug repurposing aided by computational methods. In this work, two databases containing anticandidal agents and drugs were studied employing cheminformatics and compared by similarity methods. The results showed 36 drugs with high similarities to some candicidals. From these drugs, trimetozin, osalmid and metochalcone were evaluated against C. albicans (18804), C. glabrata (90030), and miconazole‐resistant strain C. glabrata (32554). Osalmid and metochalcone were the best, with activity in the micromolar range. These findings represent an opportunity to continue with the research on the potential antifungal application of osalmid and metochalcone as well as the design of structurally related derivatives.

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Antibacterial and antifungal activities of some trimethoprim salts

Cited by 4 publications

References 9 publications

Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates

Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates

Chemicals of Emerging Concern in Treated Wastewater Impact Microbial Growth

Similarity searching for anticandidal agents employing a repurposing approach

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