Synthesis, crystal structures and DNA-binding properties of two new mononuclear copper(II) complexes

Abstract

Two mononuclear copper(II) complexes, [Cu-(bpy) 2 (CH 3 OH)](pic) 2 (1) and [Cu(Me 2 bpy) 2 (H 2 O)](pic) 2 (2) (bpy = 2,2 0 -bipyridine; Me 2 bpy = 4,4 0 -dimethyl-2,2 0 -bipyridine; Hpic = 2,4,6-trinitrophenol), were synthesized and characterized by elemental analyses, conductivity measurements, IR, UV-Visible spectroscopy and single crystal X-ray analyses. Both complexes 1 and 2 are mononuclear compounds. The copper atom in complex 1 is in a distorted square pyramidal geometry with a CuN 4 O chromophore as revealed from the s value (0.25), while the Cu(II) ion in complex 2 displays a distorted trigonal bipyramidal stereochemistry with s = 0.72. Hydrogen bonding interactions and p-p stacking interactions link the mononuclear copper complex 1 or 2 into a 1D infinite chain. The interactions of the two mononuclear complexes with herring sperm DNA (HS-DNA) have been studied by UV-visible absorption titration, fluorescence titration and ethidium bromide (EB) displacement experiments. The results suggest that both complexes might bind to DNA by intercalation.

Synthesis and structure of new dicopper(II) complexes bridged by N-(2-hydroxy-5-methylphenyl)-N′-[3-(dimethylamino)propyl]oxamide with in vitro anticancer activity: A comparative study of reactivities towards DNA/protein by molecular docking and experimental assays

“…3. The best-fit curves yield K b = [43,44], but higher than those of some monocopper(II) complexes containing Me 2 bpy or bpy ancillary ligands [45,46], indicating that the two dicopper(II) complexes strongly bind to HS-DNA, which may be related to their structural characteristics. Notably, it is generally accepted M A N U S C R I P T…”