DNA/BSA‐binding property and in vitro anticancer activity of a new dicopper(II) complex with N‐(2‐hydroxy‐5‐nitrophenyl)‐N′‐[3‐(diethylamino)propyl]oxamide as bridging ligand: Synthesis and crystal structure

Abstract

A new oxamido‐bridged dicopper(II) complex formulated as [Cu2(ndpox)(bpy)(CH3OH)2]‐ (ClO4), where H3ndpox is N‐(2‐hydroxy‐5‐nitrophenyl)‐N′‐[3‐(diethylamino)propyl]oxamide; and bpy represents 2,2′‐bipyridine, was synthesized and structurally characterized using X‐ray single‐crystal diffraction and other methods. In the molecule, the endo‐ and the exo‐copper(II) ions bridged by the cis‐ndpox3− ligand are in {N3O2} and {N2O3} square‐ pyramidal environments, respectively. There is a three‐dimensional hydrogen bonding network dominated by O‐H···O and C‐H···O interactions in the crystal. The reactivity toward DNA/protein bovine serum albumin (BSA) revealed that the complex could interact with herring sperm DNA (HS‐DNA) through the intercalation mode, and effectively quench the intrinsic fluorescence of BSA via a static process. Cytotoxicity studies suggest that the complex displays selective cancer cell antiproliferative activity. The present investigation confirmed that the combined effects of both electron‐withdrawing and hydrophobic groups on the bridging ligand in the dicopper(II) complex systems can increase DNA/BSA‐binding ability and in vitro anticancer activity.

Silver(I) Complexes with Mefenamic Acid and Nitrogen Heterocyclic Ligands: Synthesis, Characterization, and Biological Evaluation

“…Furthermore, many drugs contain N-heterocycles, and some have shown biological activity. − When N-heterocyclic compounds form complexes with metals, they also exhibit a variety of biological activities; nitrogen heterocyclic complexes have shown their ability to bind with DNA/BSA and exhibited anticancer activity. − Among them, the metal complexes formed by pyridine derivatives demonstrate good antitumor activity and multiple forms of antitumor applications. − A small amount of metal complexes produced by pyrazine derivatives also display anticancer activity. − …”