Synthesis, Characterization and Activity against Staphylococcus of Metal(II)‐Gatifloxacin Complexes

Abstract

Three novel isostructural complexes M(gatx) 2 (H 2 O) 2 •4H 2 O [gatx＝gatifloxacin, M＝Zn (1), Ni (2) and Co (3)] were synthesized at room temperature and structurally characterized by elemental analysis, IR and single crystal X-ray diffraction, which exhibit a similar mononuclear structure, in which the metal ion is coordinated by two gatifloxacin and two aqua ligands to furnish a distorted octahedral geometry, and show different activities against staphylococcus due to the different metal ions in the structures.

Zinc complexes of the antibacterial drug oxolinic acid: Structure and DNA-binding properties

“…Zinc plays an important role in various biological systems; it is critical for numerous cell processes and is a major regulatory ion in the metabolism of cells [3]. In the literature, diverse zinc complexes with biological activity are reported, but only zinc complexes with drugs used for the treatment of Alzheimer disease [4] and others showing antibacterial [5], anticonvulsant [6], antidiabetic [7], anti-inflammatory [8], antimicrobial [9] and antiproliferative-antitumor [10][11][12][13] activity are structurally characterized.…”

Determination of organothiophosphorus pesticides in water by liquid chromatography and post-column chemiluminescence with cerium(IV)

“…In fact, CL has been gaining increasing acceptance and has been used to determine OPPs residues in recent years [9][10][11][12][13][14][15]. Nevertheless, practical application of the HPLC-CL technique for the determination of pesticides is still uncommon.…”

Synthesis, Crystal Structure and DNA-Binding Properties of a Zinc(II) Complex with 1,3-Bis(1-propylbenzimidazol-2-yl)-2-oxapropane

“…Zinc plays an important role in various biological systems; it is critical for numerous cell processes and is a major regulatory ion in the metabolism of cells [16]. In the literature, diverse zinc complexes with biological activity are reported, but only zinc complexes with drugs used for the treatment of Alzheimer disease [17] and others showing antibacterial [18], anticonvulsant [19], antidiabetic [20], anti-inflammatory [21], antimicrobial [22] and antiproliferative-antitumor [23] activity are structurally characterized [24].…”