Synthesis, Spectroscopic Characterization and Antimicrobial Studies of Some Metal Complexes of 5-Isopropylidene-1-Methyl-2, 4-Dithiobiuret Hydrochloride

Abstract

The ligand 5-isopropylidene-l-methyl-2,4-dithiobiuret hydrochloride (HIMDTB.HCI) has been prepared by reacting 1 -methyl-2,4-dithiobiuret with ethyl chloroformate in the presence of acetone. New transition metal complexes of the type Ni(IMDTB)2, CO(IMDTB)~.~H~O, [Cu(HIMDTB)C1]2 and M(HUIDTB)S04 = Zn(1I) and Cd(n)] have been synthesized and characterized. Molar conductance values revealed that the bivalent metal ions are non-ionic in Dh4F. The electronic spectra, FT-IR spectra and magnetic moments of the complexes are suggestive of a square-planar geometry for Ni(II), octahedral geometry for Co(II), pseudotetrahedral stereochemistry for Cum) and charge transfer for Zn(II) and Cd(II). The complexes have been characterized by physicochemical and spectroscopic methods. They have been preliminarily examined for antibacterial and antfingal activities against selected microbial strains and are found to be selective growth inhibitors of Stuphylwwcus aureus and Escherichia coli in particular.935

Magnetic and Spectral Studies of Divalent Metal Complexes of Isonitroso-5-Methyl-2-Hexanone and Its Derivative

“…The molar conductance had been measured using 10 22 M solution in DMF. The values indicate that they are non-ionic in nature (Geary, 1971;Naik et al, 1999).…”

“…The broad band observed in the range 3420-3390 cm 21 is due to the -OH vibration of water molecule (Limin, 1997) (Table 3). The IR spectrum of H 2 MHDDO shows a broad band centered at 3322 cm 21 , due to the -OH stretching vibration of the oxime group (Geary, 1971;Naik et al, 1999). This -OH band is observed in the range 3240 -3360 cm 21 in the H 2 MHDDO complexes, which indicates that, one oxime group is not involved in the bonding.…”