Iron and nickel complexes with heterocyclic ligands: Stability, synthesis, spectral characterization, antimicrobial activity, acute and subacute toxicity

Bouchoucha, Afaf; Terbouche, Achour; Zaouani, Mohamed; Derridj, Fazia; Djebbar, Safia

doi:10.1016/j.jtemb.2012.12.001

Cited by 22 publications

(10 citation statements)

References 33 publications

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“…Even though these in vitro studies set the basis for pharmacological applications, as it has been shown in several reports 73, 74 , both bioavailability and biodistribution of the transition metals used here need to be obtained in animal models in order to determine their safety.…”

Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza-Cervantes

Chávez‐Reyes²,

Castillo

et al. 2017

Sci Rep

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Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E. coli and B. subtilis. We find that most combinatorial treatments exhibit synergistic antimicrobial effects at low/ non-toxic concentrations to human keratinocyte cells, blast and melanoma rat cell lines. Moreover, we show that silver/(Cu, Ni, and Zn) increase prokaryotic cell permeability at sub-inhibitory concentrations, demonstrating this to be a possible mechanism of the synergistic behavior. Together, these results suggest that these combinatorial treatments will play an important role in the future development of antimicrobial agents and treatments against infections. In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.

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Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza-Cervantes

Chávez‐Reyes²,

Castillo

et al. 2017

Sci Rep

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“…About 1 ml of young bacterial and fungal inocula containing approximately 10 6 CFU/ml Colony Forming Unite was spread on the surface of the nutrient agar and Sabouraud Dextrose Broth, with the help of a sterile cotton swab. The tested compounds were dissolved in DMSO solvent at concentration of 5 and 10 mg/ml [37,38]. The wells (6mm in diameter) were punched carefully using a sterile Pipette Pasteur and 25µL of tested solutions at different concentrations were added into each labeled well.…”

Section: Biological Studiesmentioning

confidence: 99%

“…The difference in the observed electronic absorptions could be related to the different electronic It is also noted from Table 3 that The electronic data of the complexes are summarized in Table 4.Five absorption bands are observed for all complexes. Two are located in UV region in the range260-280nm and 315-335 nm due to the π→π* and n→π * intraligand transitions [30,37] and are displaced with respect in the ligands. This indicates that the ligands are present around the central metal.…”

Section: Nmmentioning

confidence: 99%

Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Allab

Chikhi

Zaater

et al. 2020

Inorganica Chimica Acta

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Six new nickel (II) complexes with a series of tetrazole derivatives functionalized by different substituents {5-(2-(1-Benzyltetrazol-5-yl) phenyl)-2-ethyl-4-methylthiazole (L 1), 1-Benzyl-5-(2-(1methylpyrrol-2-yl)phenyl) tetrazole (L 2), 5-(2-(1-Pivalyltetrazol-5-yl)phenyl)-2-ethyl-4methylthiazole (L 3), 5-(2-(1-Methylpyrrol-2-yl) phenyl)-1-pivalyltetrazole (L 4), 2-Ethyl-4-methyl-5-(2-(1 methyltetrazol-5-yl) phenyl) thiazole (L 5) and 1-Methyl-5-(2-(1-methylpyrrol-2-yl)phenyl) tetrazole (L 6)} have been synthesized and characterized by analytical and spectral methods. The data clearly indicated that the nickel (II) complexes are coordinated to the monodentate tetrazole derivatives via nitrogen (N3) atom of the tetrazole ring. The octahedral geometry is observed for all the complexes. The thermogravimetric analysis revealed the presence of coordinated and hydrated water molecules in the coordination sphere. The DFT calculations performed on both the ligands and the complexes allowed to optimize the structures, the stability and to explain the electrochemical behavior and the biological activities of the nickel (II) complexes. The study of the substituents effects on the redox properties of the ligands and their nickel (II) complexes were discussed via cyclic voltammograms. Electron donating substituents shift the reduction potentials toward negative values, while anodic shift of the oxidation potentials is manifested by the substituents having an electron withdrawing effect. The in vitro antimicrobial activities of the ligands and their corresponding nickel (II) complexes have been evaluated against four bacterial and two fungal strains.

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“…Otros sistemas corporales en los que el Ni puede deteriorar o inducir una alteración funcional incluyen la sangre, el sistema cardiovascular, las vías de detoxificación de la piel, el colon, el riñón y el hígado, el sistema endocrino (hormonal), así como los procesos de producción de energía, el enzimático, el gastrointestinal, el inmune y el nervioso (Bouchoucha, Terbouche, Zaouani, Derridj, & Djebbar, 2013;Das et al, 2010).…”

Section: Otros Efectos Tóxicosunclassified

“…Finalmente, en otro estudio reciente, desarrollado en animales de experimentación (ratones) por Bouchoucha et al (2013), se comprobó que los complejos de Ni mostraron una dosis letal 50 (DL 50 ) que osciló entre 600 y 835 mg/kg de peso corporal.…”

Section: Otros Efectos Tóxicosunclassified

Níquel en alimentos y factores influyentes en sus niveles, ingesta, biodisponibilidad y toxicidad: una revisión

Arias

Valverde-Som

Rodríguez

et al. 2014

CyTA - Journal of Food

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Iron and nickel complexes with heterocyclic ligands: Stability, synthesis, spectral characterization, antimicrobial activity, acute and subacute toxicity

Cited by 22 publications

References 33 publications

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Níquel en alimentos y factores influyentes en sus niveles, ingesta, biodisponibilidad y toxicidad: una revisión

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