New complexes of manganese (II), nickel (II) and copper (II) with derived benzoxazole ligands: Synthesis, characterization, DFT, antimicrobial activity, acute and subacute toxicity

Bouchoucha, Afaf; Terbouche, Achour; Bourouina, Assia; Djebbar, Safia

doi:10.1016/j.ica.2014.04.016

Cited by 22 publications

(8 citation statements)

References 57 publications

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“…The toxicological results showed that a dose of 2000 mg/Kg body weight (mice NMRI) of both complexes seemed to be non‐toxic. The sub‐acute reading during the 14 days observations designated the nonexistence of cumulative toxicity and detected no adverse effects at 350 mg/kg body weight of animal …”

Section: Mn–complexes With Bidentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.

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Section: Mn–complexes With Bidentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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“…These absorption ranges correspond to the composition of well-selected octahedral configuration around Ni (II) [58][59][60]. The observed magnetic moment values (table 1) of nickel complexes indicate the paramagnetic nature of Ni (II), which confirms the octahedral structure of these nickel complexes [30,37,38]. 112…”

Section: Nmmentioning

confidence: 68%

“…The tested compounds were dissolved in Dimethyl Sulfoxide (DMSO) at two concentrations 10 and 5 mg/ ml. Further, we notice that the different activities of the ligands are clearly related to the different substituents located in position 1 and 5 of the ligands and their electronic parameters [86,30]. The ligands L 5 and L 6 were inactive against all bacterial strains.…”

Section: Redox Properties Of the Nickel (Ii) Complexesmentioning

confidence: 83%

“…The Geometry optimization of the complexes in the ground state have been accomplished by Density Functional Theory (DFT) method using Beck's three parameters hybrid method and the Lee-Yang-Parr (B3LYP) correlation functional [30][31][32].…”

Section: Methodsmentioning

confidence: 99%

“…The difference in the observed electronic absorptions could be related to the different electronic It is also noted from Table 3 that The electronic data of the complexes are summarized in Table 4.Five absorption bands are observed for all complexes. Two are located in UV region in the range260-280nm and 315-335 nm due to the π→π* and n→π * intraligand transitions [30,37] and are displaced with respect in the ligands. This indicates that the ligands are present around the central metal.…”

Section: Nmmentioning

confidence: 99%

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Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Allab

Chikhi

Zaater

et al. 2020

Inorganica Chimica Acta

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Six new nickel (II) complexes with a series of tetrazole derivatives functionalized by different substituents {5-(2-(1-Benzyltetrazol-5-yl) phenyl)-2-ethyl-4-methylthiazole (L 1), 1-Benzyl-5-(2-(1methylpyrrol-2-yl)phenyl) tetrazole (L 2), 5-(2-(1-Pivalyltetrazol-5-yl)phenyl)-2-ethyl-4methylthiazole (L 3), 5-(2-(1-Methylpyrrol-2-yl) phenyl)-1-pivalyltetrazole (L 4), 2-Ethyl-4-methyl-5-(2-(1 methyltetrazol-5-yl) phenyl) thiazole (L 5) and 1-Methyl-5-(2-(1-methylpyrrol-2-yl)phenyl) tetrazole (L 6)} have been synthesized and characterized by analytical and spectral methods. The data clearly indicated that the nickel (II) complexes are coordinated to the monodentate tetrazole derivatives via nitrogen (N3) atom of the tetrazole ring. The octahedral geometry is observed for all the complexes. The thermogravimetric analysis revealed the presence of coordinated and hydrated water molecules in the coordination sphere. The DFT calculations performed on both the ligands and the complexes allowed to optimize the structures, the stability and to explain the electrochemical behavior and the biological activities of the nickel (II) complexes. The study of the substituents effects on the redox properties of the ligands and their nickel (II) complexes were discussed via cyclic voltammograms. Electron donating substituents shift the reduction potentials toward negative values, while anodic shift of the oxidation potentials is manifested by the substituents having an electron withdrawing effect. The in vitro antimicrobial activities of the ligands and their corresponding nickel (II) complexes have been evaluated against four bacterial and two fungal strains.

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