The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.
The construction of metallosupramolecular
complexes toward interesting topological structures is a critical
challenge for chemists. The fluctuation in the synthetic strategy,
by keeping the same metal–ligand combination, has proved a
very significant approach to construct metallosupramolecular architectures.
Herein, by varying the reaction conditions four new DyIII-supramolecular complexes based on a flexible dihydrazone ligand
H2L (H2L = bis(2-hydroxy-3-methoxybenzylidene)adipohydrazide)
in cooperation with different anions and solvents having formulas
[Dy4L4(μ2-N3)2](NO3)2·6CH3OH·2H2O (1), [Dy8L8(μ2-CH3OH)4]Cl8·6CH3OH·14H2O (2), [Dy12L12(μ2-OH)2(OH)6(CH3O)2](NO3)2·2CH3OH·14H2O (3), and [Dy12L12(μ2-OH)2(NO3)2(OH)3(CH3O)](NO3)4·22H2O (4), have been successfully
synthesized and their crystal structures confirmed by single crystal
X-ray diffraction studies. The structural study reveals that 1 and 2 have quadruple-stranded helicate and
dual triple-stranded helicate supramolecular structures, respectively,
while 3 and 4 display “octahedron”
cagelike supramolecular structures. The magnetic studies reveal that
complexes 1–3 exhibit slow magnetic
relaxation behavior, while complex 4 displays a series
of typical frequency-dependent relaxation signals at 0 Oe applied
dc field which is a rare case in polynuclear 4f single-molecule magnet
(SMM) family to date. Interestingly, the distinct magnetic dynamic
behavior was noticed for nearly isoskeletal complexes 3 and 4, which can be attributed to the modification
of the coordination environment around DyIII ions.
This paper highlights the compounds containing Sb cluster fragments, either synthesized in the solid‐state, discovered from the gas phase, or only theoretically predicted. These Sbn clusters feature unique chemical bonding, fascinating structures, and special stabilities that can be well rationalized by aromaticity or antiaromaticity. A deep understanding to their electronic structures is essential and will greatly facilitate the experimental synthesis of new Sbn cluster‐based materials.
A family of four mononuclear DyIII complexes of guanidine-based ligand L [L = tris(2-hydroxybenzylidene)triaminoguanidine] with formulas [DyLCl2(DMF)2]·DMF·CH3OH (1), [DyL2(CH3OH)2]Br·H2O·3CH3OH (2), [DyL2(H2O)2]SCN·3H2O·CH3OH) (3) and [DyL2(CH3OH)2]SCN·CH3CN·CH3OH (4) were successfully prepared by fluctuating...
AbstractThis article describes an overview of the synthetic techniques and protocols for the preparation of new ligands and respective manganese (Mn) complexes to be tested for biomedical applications. Mn is an essential and biocompatible element, the complexes of which have diverse medicinal applications. The most significant use of Mn complexes is their application against reactive oxygen species in biological systems, and due to this, three Mn-incorporated complexes (AEOL-10150, EUK-134, and M40403) are already under clinical trials. Hence, the interest in synthesizing biologically active Mn complexes is rapidly increasing. Mn complexes are commonly synthesized using either water or ethanol as a reaction medium for their possible usage in biological systems. Using common Mn salts along with suitable organic ligand works well in the presence of little heat to obtain Mn complexes of interest.
In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25and#177;0.02 to 5.04and#177;0.2 and#181;M. On the other hand all the compounds didn’t show cytotoxic activity against other forms of human cancer cells.
Two C3-symmetric guanidine-based copper triangles bridged by acetates in a cis manner and by chloride anions in a trans manner, respectively gave rise to two antiferromagnetically coupled hexanuclear CuII compounds, namely [Cu6L2Cl(μ-OAc)(DMF)3]·DMF (Cu6) and [Cu6L2(μ-Cl)2(DMF)4] (Cu6Cl)(where L stands for fully deprotonated tris (2-hydroxybenzylidene) triaminoguanidinium chloride, H5L). The experimental magnetic data of the two compounds were analyzed theoretically. A relatively good agreement with the experimental data was obtained when using the wavefunction theory (CASSCF) in combination with DFT (B3LYP) calculations for the very strong antiferromagnetic coupling within the Cu3 triangles (Javg = − 300 cm−1 for Cu6 and Javg = − 250 cm−1 for Cu6Cl), leading to spin-frustrated systems. It is worth mentioning that the electronic structure of each CuII center remains very similar in each complex with a Kramers ground state well separated from the first excited state (over 12000 cm−1) and weakly anisotropic (g∥ ≈ 2.40 and g⊥ ≈ 2.10).
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