Techniques in the synthesis of mononuclear manganese complexes: a review

Abstract

<jats:title>Abstract</jats:title><jats:p>This article describes an overview of the synthetic techniques and protocols for the preparation of new ligands and respective manganese (Mn) complexes to be tested for biomedical applications. Mn is an essential and biocompatible element, the complexes of which have diverse medicinal applications. The most significant use of Mn complexes is their application against reactive oxygen species in biological systems, and due to this, three Mn-incorporated complexes (AEOL-10150, EUK-134, and M40403) are already under clinical trials. Hence, the interest in synthesizing biologically active Mn complexes is rapidly increasing. Mn complexes are commonly synthesized using either water or ethanol as a reaction medium for their possible usage in biological systems. Using common Mn salts along with suitable organic ligand works well in the presence of little heat to obtain Mn complexes of interest.</jats:p>

Cytotoxic and Pro-Apoptotic Properties of Ethyl-p-Methoxycinnamate and Its Hydrophilic Derivative Potassium-p-Methoxycinnamate

“…Cancer has been a major concern in most of the research that has been published in the past decade under the umbrella of molecular biology, medicine and synthetic chemistry [1][2][3]. A wide range of novel compounds and their metallic complexes have been reported recently for their anticancer and proapoptotic potential [2,[4][5][6][7][8][9].…”