Cytotoxicity and Antimicrobial Activity of Pivalic and Benzoic Acid-Complexed Cu and Mn Complexes

Ali, Basharat; Tahir, Sadia; Akhtar, Muhammad Nadeem; Yameen, Muhammad Arfat; Ashraf, Rizwan; Hussain, Tariq; Ghaffar, Abdul; Abbas, M. N.; Bokhari, Tanveer Hussain; Iqbal, Munawar

doi:10.15244/pjoes/68536

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Organic aromatic carboxylates are an important family of multiple-dentate O-electron-donor ligands to form coordinate bonding with metal ions. − The carboxylic functional group, especially two such functional groups in adjacent substituents on the benzene ring, is capable of bonding with metal, thereby mediating the bioavailability of metals. , Among the target aromatic acids, o -phthalic acid, 1,2,3-BTCA, and 1,3,5-BTCA serve as the ligands complexing with transition metals such as Copper(II), Iron(II), Manganese(II), and Zinc(II) by coordinating through carboxylate oxygen. − For example, Baca et al enumerated the coordination modes of o -phthalic acid as ligand with metals from monodentate, didentate to heptad-dentate. Quantitative abundance measurements of carboxylate ligands provide necessary data to assist the assessment of toxicological effects posed by metal species. − …”

Section: Introductionmentioning

confidence: 99%

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China

He¹,

Huang²,

Chow³

et al. 2018

ACS Earth Space Chem.

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The organic composition of airborne fine particulate matter (PM 2.5 , aerodynamic diameter less than 2.5 μm) at a molecular level has yet to be achieved, hindering a full understanding of the climatic impacts and health effects of PM 2.5 . Compounds containing aromatic rings are closely associated with optically active brown carbon and toxicologically important quinones. In this work, a group of ten aromatic organic acids including three phthalic acids, four phenolic acids, and three benzene-tricarboxylic acids (BTCAs) in PM 2.5 were studied for their abundance and potential sources through quantifying their ambient concentrations at four sites in the Pearl River Delta (PRD) region in Southern China, where biomass burning and anthropogenic emissions are both significant PM sources. Average concentrations of individual aromatic acids in a total of 240 PM 2.5 samples collected throughout 2012 were in the order of 0.1−20 ng/m 3 with p-and o-phthalic acid being the most abundant. Interspecies correlation analysis with known PM source tracers reveals different source origins for the ten aromatic acids. The four phenolic acids, all possessing partial lignin structures, are highly correlated with levoglucosan, indicating their association with biomass burning emissions. Specific lignin tracer ratios characteristic of different types of biomass fuels (i.e., cinnamyl-to vanillyl-phenol ratio) revealed the significant influence of crop burning emissions in the PRD region. The three BTCAs have moderate correlation with sulfate but no correlation with levoglucosan, suggesting a strong association with secondary formation origins while negating a strong link with biomass burning. The three phthalic acids are moderately correlated with sulfate, levoglucosan, and a number of polycyclic aromatic hydrocarbons (PAHs), indicating multiple significant sources. This study provides a valuable data set toward establishing quantitative links between molecular composition of organic matter and the optical and toxicological properties of PM 2.5 as well as assisting identification of tracers for PM 2.5 sources.

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Section: Introductionmentioning

confidence: 99%

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China

He¹,

Huang²,

Chow³

et al. 2018

ACS Earth Space Chem.

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“…In human medicine, there are reports of anti-inflammatory, anti-ulcer, antiseizure, anti-emetic, antitumour and anti-ISSN 2052-5206 microbial activity of these compounds. In general, the biological action of the ligand is enhanced through the formation of complexes with metal ions that possess similar activity, hence the importance of the coordination compounds of imidazole with transition metals, copper in the present study, which has antimicrobial activity (Roat, 2007;Ali et al, 2017).…”

Section: Introductionmentioning

confidence: 96%

Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction

Zapata¹,

Carmona²,

Echeverría³

et al. 2022

Acta Crystallogr Sect B

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The crystal structures of bis[1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-ium-4-yl)-1,4-dihydroquinoline-3-carboxylato]copper(II) sulfate heptahydrate, [Cu(C16H18FN3O3)2]SO4·7H2O or [Cu(nor)2]SO4·7H2O (nor is norfloxacin), and bis{1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimide}dinitratocopper(II), [Cu(NO3)2(C8H13N3O4S)2] or [Cu(NO3)2(tnz)2] (tnz is tinidazole), were solved by X-ray diffraction. Both complexes crystallize in the space group P21/c, with Z = 4 (for nor) and Z = 2 (for ntz) molecules per unit cell. In [Cu(nor)2]SO4·7H2O, the CuII ion is at the centre of a square-planar environment, trans coordinated to two independent norfloxacin molecules in the zwitterionic form acting as bidentate ligands through one of the carboxyl (cbx) and the carbonyl (cb) O atoms. The solid is further stabilized by an extensive network of N—H...O(sulfate), N—H...O(cbx), N—H...OW, OW—H...O(sulfate) and OW—H...OW hydrogen bonds. The [Cu(NO3)2(tnz)2] complex is centrosymmetric, with the CuII ion in a square planar environment, coordinated to a tinidazole molecule acting as a monodentate ligand through its imidazole N atom and to one nitrate O atom. The vibrational FT–IR absorption spectra and thermal behaviour of the complexes were also studied and are briefly discussed based on the crystal structures.

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“…A copper (II) complex with pivalic acid and imidazole was prepared in the presence of sodium azide. An antibacterial assay revealed that complex II123 was active against Escherichia coli , Staphylococcus aureus , and Pasteurella multocida bacteria, showing the strongest inhibitory activity against Escherichia coli [ 268 ].…”

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

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Cytotoxicity and Antimicrobial Activity of Pivalic and Benzoic Acid-Complexed Cu and Mn Complexes

Cited by 5 publications

References 18 publications

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China

Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

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Cytotoxicity and Antimicrobial Activity of Pivalic and Benzoic Acid-Complexed Cu and Mn Complexes

Cited by 5 publications

References 18 publications

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM2.5 at Urban and Suburban Sites in Southern China

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM2.5 at Urban and Suburban Sites in Southern China

Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Contact Info

Product

Resources

About

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China

Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM_2.5 at Urban and Suburban Sites in Southern China