Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics

Fereydouni, Narges; Movaffagh, Jebrail; Amiri, Nafise; Darroudi, Susan; Gholoobi, Aida; Goodarzi, Arash; Hashemzadeh, Alireza; Darroudi, Majid

doi:10.1038/s41598-020-73678-w

Cited by 54 publications

(31 citation statements)

References 92 publications

(107 reference statements)

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“…Secondly, its metabolism in the organism intestine and liver is very fast [54]. At present, the use of polymer synthesis technology to prepare amphiphilic polycurcumin block copolymers with CUR as a comonomer has overcome the shortcomings of CUR in water solubility and poor stability [55][56][57]. Although low-dose CUR can protect MAC-T cells from LPS damage in our research results, if you want to use it in animal husbandry production A new in vivo experiment is needed to determine the most suitable CUR dosage.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway

Fang

Shen

et al. 2021

Toxins

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Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. The purpose of this study is to investigate whether CUR can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by LPS and its underlying molecular mechanism. The MAC-T cell line was treated with different concentrations of LPS and CUR for 24 h. The results showed that CUR rescued the decrease of MAC-T cell viability and cell damage induced by LPS. At the same time, 10 µM CUR and 100 µg/mL LPS were used to treat the cells in the follow-up study. The results showed CUR treatment reduced the accumulation of reactive oxygen species (ROS), the expression of inflammatory cytokines (tumor necrosis factor-a (TNF-α), interleukin-8 (IL-8), IL-6 and IL-1β) and the rate of apoptosis induced by LPS. These effects were associated with the activation of the nuclear factor E2-related factor 2 (NFE2L2)-antioxidant response element (ARE) pathway coupled with inactivation of the nuclear factor-κB (NF-κB) inflammatory and caspase/Bcl2 apoptotic pathways.

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Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway

Fang

Shen

et al. 2021

Toxins

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“…The suitable WVP rate promotes the wound dehydration and scar generation. In contrast, low WVP rate can bring about exudate accumulation at wound, resulting in delaying healing process and occurring infection [ 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Cotton Cellulose-Derived Hydrogel and Electrospun Fiber as Alternative Material for Wound Dressing Application

Jirawitchalert

Mitaim

Chen

et al. 2022

International Journal of Biomaterials

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Cotton has been recognized as a useful biomaterial over decades, and it has been widely applied in the textile industry. However, a large amount of cotton waste is generated during the manufacturing processes, but it has been considered as a low-value product. With high content of cellulose remaining in cotton waste, our study focuses on transforming cotton cellulose into a valuable product. Cellulose was extracted from cotton waste and modified into two main materials for wound dressing application: hydrogel-based water absorbent materials and electrospun composite nanofibers. In order to enhance the water absorption, carboxymethyl cellulose (CMC), the modified cellulose with functional group prone to interact with water molecules, has been developed in this study. The hydrogel-based CMC was created by using the chemical cross-linking reaction of epichlorohydrin (ECH). The hydrogel demonstrated the swelling and reswelling ability by 1718 ± 137% and 97.95 ± 9.76%, respectively. Meanwhile, cellulose/PEG in trifluoroacetic acid (TFA) was successfully fabricated as nonwoven composite by a conventional electrospinning technique. The fabrics provided highly appropriated properties as wound dressing, including the following: water absorption was up to 1300 times and water vapor permeability controlled in the range of 2163–2285 g·m−2·day−1. This showed the preliminary information for recovering cotton waste into valuable products.

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“…It is a hydrophobic protein, soluble in alcohol, widely used in the food industry and biomedical field [134]. Zein is a hard but flexible material with excellent antibacterial and antioxidant properties [135,136]. As the interest of scientific community has shifted towards finding suitable materials for controlled drug delivery in vivo, zein has emerged as a potential candidate due to its biocompatibility and biodegradability [137].…”

Section: Epd Of Zein Based Coatingsmentioning

confidence: 99%

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

et al. 2021

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Electrophoretic deposition (EPD) is a powerful technique to assemble metals, polymer, ceramics, and composite materials into 2D, 3D, and intricately shaped implants. Polymers, proteins, and peptides can be deposited via EPD at room temperature without affecting their chemical structures. Furthermore, EPD is being used to deposit multifunctional coatings (i.e., bioactive, antibacterial, and biocompatible coatings). Recently, EPD was used to architect multi-structured coatings to improve mechanical and biological properties along with the controlled release of drugs/metallic ions. The key characteristics of EPD coatings in terms of inorganic bioactivity and their angiogenic potential coupled with antibacterial properties are the key elements enabling advanced applications of EPD in orthopedic applications. In the emerging field of EPD coatings for hard tissue and soft tissue engineering, an overview of such applications will be presented. The progress in the development of EPD-based polymeric or composite coatings, including their application in orthopedic and targeted drug delivery approaches, will be discussed, with a focus on the effect of different biologically active ions/drugs released from EPD deposits. The literature under discussion involves EPD coatings consisting of chitosan (Chi), zein, polyetheretherketone (PEEK), and their composites. Moreover, in vitro and in vivo investigations of EPD coatings will be discussed in relation to the current main challenge of orthopedic implants, namely that the biomaterial must provide good bone-binding ability and mechanical compatibility.

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Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics

Cited by 54 publications

References 92 publications

Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway

Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway

Cotton Cellulose-Derived Hydrogel and Electrospun Fiber as Alternative Material for Wound Dressing Application

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

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