Synthesis of 2-Allylphenyl Cinnamate and Brine Shrimp Lethality Test Activity Evaluation

Primahana, Gian; Ernawati, Teni; Dewi, Nuryah; Dwiyatmi, Indah Dewijanti; Darmawan, Akhmad; Hanafi, Muhammad

doi:10.1016/j.proche.2015.12.014

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…Toxicity test was done for proving that herbal oil is non-toxic as an external medicine. In most cases, Artemia salina larvae were applied as an experimental animal in toxicity test, due to it can be used for initial screening as a substitute for cell lines (in-vitro) with more easily, quickly, cheaply, and ethically (Hisem et al 2011;Primahana et al 2015;Arumugam et al 2019). The BSLT method well correlated with in-vitro tests on cell lines, where extracts of dichloromethane:methanol (2:1) from microalgae and podophylloytoxin drugs were proven to be toxic on Artemia salina and cell lines (human nasopharyngal carcinoma and human colon adenocarcinoma) (Mian et al 2003;Jaki et al 1999;Hisem et al 2011).…”

Section: Toxicitymentioning

confidence: 99%

Impact of using low-cost packaging material of commercial herbal oil on its antibacterial compounds

2020

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A commercial herbal oil with different bottle materials on the Indonesian markets was studied. The effects of the different specimens viz. PET-new, PET-open, and AL-new on the main antibacterial components of herbal oil were investigated.Step-1, analysis of antibacterial activity (against S. aureus and E. coli) and testing of non-toxic (in-vivo).Step-2, detection of the main antibacterial compounds (6 types) during the storage times. The market and environmental aspects were also considered. The results, all specimens had antibacterial activity and they showed non-toxic. At the 0-month, six types of main antibacterial compounds were detected in all specimens. The longer the storage time, the more main antibacterial compounds were lost. The most loss (4 types) was observed in and PET-open. PET-new showed the least loss (1 type) at 6-months and 12-months, namely eugenol. Interestingly, PET-new was able to retain curcumene, farnesol, and p-cymene for up to 12 months of storage. PET-new was also more economical (8.7% cheaper) and environmental-friendly than AL-new. The sprayer cap types are strongly recommended for PET herbal oil packaging.

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Section: Toxicitymentioning

confidence: 99%

Impact of using low-cost packaging material of commercial herbal oil on its antibacterial compounds

2020

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“…The brine shrimp lethality test was conducted to predict the preliminary toxicity which could provide a possible indication of cytotoxic properties of produced FCNPs [52][53] . Three replicates with three trials each were conducted, which is composed of controlled set-up, negative control (40% EtOH) and increasing concentrations of FCNPs in saline solution as shown in Table 2.…”

Section: Phytochemistry Of As-prepared Fcnpsmentioning

confidence: 99%

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Calangian¹,

Ildefonzo²,

Manzano³

et al. 2018

Orient. J. Chem

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Biologically derived carbon-based nanomaterials have been gaining attention in the recent years due to its various potential medical applications. In this study, fluorescent carbon nanoparticles (FCNPs) derived from an abundant alga, Cladophora vagabunda, is first reported. FCNPs with an average diameter of ~43 nm was synthesized via hydrothermal process, a simple and green method. The synthesized FCNPs exhibited absorbances in the ultraviolet to visible regions and emissions at 600 and 650 nm. Phytochemical screening and bioactivity tests were conducted to determine various bioactive compounds present in the FCNP surface and its antibacterial, antioxidant, and cytotoxic properties. Results showed that FCNPs from C. vagabunda contains tannin, saponin, flavonoids, and phenolic compounds which are known for their antimicrobial property as supported by the result of agar well diffusion method using a Gram-positive S. aureus and Gram-negative E. coli. Moreover, FCNPs shows inactive cytotoxicity using brine shrimp lethality test at ratio as high as 1:1 in 40% (v/v) ethanol. The results suggest the potential use of FCNPs from C. vagabunda as a fluorescent material with various biological activities.

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“…Brine shrimp lethality test (BSLT) is an early toxicity test using Artemia salina leach nauplii (Primahana et al, 2015). BSLT method is based on the cytotoxic ability of a bioactive compound to kill zoology organism A. salina Leach.…”

Section: Introductionmentioning

confidence: 99%

“…The result is shown in LC50 in µg/ml, which is the compound's ability to cause 50% death in tested animals (Leliani, Natsir, Dali, & Sartika, 2019). BSLT is usually used as an early screening to toxicity assessment, which also gives the probability of cytotoxic indication from the test material, including for anticancer (Primahana et al, 2015). The brine shrimp assay is often used due to its simple, cheap, and direct characteristics which facilitate toxicity assessment from the natural product extracts, pure organic compounds, and synthetics (War Naw et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan

Setyaningtyas

Riyani

Kurniasih

et al. 2021

Molekul

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Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study aimed at synthesizing tripolyphosphate crosslinked chitosan (TPP-Cs) to test the antioxidant and toxicity. Synthesizing tripolyphosphate chitosan was conducted using ionic gelation method. The antioxidant activity test was studied from DPPH radicals scavenging and the ability to inhibit linoleic acid oxidation. The toxicity test was using BSLT (Brine Shrimp Lethality Test) method and Artemia salina leach nauplii. The study showed that TPP-Cs could be synthesized from pink shrimp and showed antioxidant activity. The activity was due to amino and hydroxyl groups. The BSLT method showed that TPP-Cs had the potential to be applied for antibacterial, antivirus, or anticancer products.

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Synthesis of 2-Allylphenyl Cinnamate and Brine Shrimp Lethality Test Activity Evaluation

Cited by 11 publications

References 18 publications

Impact of using low-cost packaging material of commercial herbal oil on its antibacterial compounds

Impact of using low-cost packaging material of commercial herbal oil on its antibacterial compounds

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan

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