Superior Wound Healing Effect of Topically Delivered Silver Nanoparticle Formulation Using Eco-Friendly Potato Plant Pathogenic Fungus: Synthesis and Characterization

Thirumurugan, G.; Veni, V. Satya; Ramachandran, Somasundaram; Rao, J. V. L. N. Seshagiri; Dhanaraju, Magharla Dasaratha

doi:10.1166/jbn.2011.1336

Cited by 35 publications

(20 citation statements)

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“…43 The results of the current study seemed to be consistent with those published previously. 44,45 For instance, Thirumurugan et al 44 synthesized AgNPs from potato plant pathogenic fungus. The results of woundhealing activity of the AgNP 0.125% (w/w) ointments revealed significant wound-healing properties compared to standard silver sulfadiazine ointment currently available in the market.…”

Section: Study Of Bacteria-killing Kineticsmentioning

confidence: 99%

Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties

Ashour

Raafat

El‐Gowelli

et al. 2015

IJN

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Background The growing threat of microbial resistance against traditional antibiotics has prompted the development of several antimicrobial nanoparticles (NPs), including silver NPs (AgNPs). In this article, a simple and eco-friendly method for the synthesis of AgNPs using the cranberry powder aqueous extract is reported. Materials and methods Cranberry powder aqueous extracts (0.2%, 0.5%, and 0.8% w/v) were allowed to interact for 24 hours with a silver nitrate solution (10 mM) at 30°C at a ratio of 1:10. The formation of AgNPs was confirmed by ultraviolet-visible spectroscopy and their concentrations were determined using atomic absorption spectroscopy. The prepared NPs were evaluated by transmission electron microscopy, measurement of ζ-potential, and Fourier-transform infrared spectroscopy. The in vitro antimicrobial properties of AgNPs were then investigated against several microbial strains. Finally, in vivo appraisal of both wound-healing and antimicrobial properties of either plain AgNPs (prepared using 0.2% extract) or AgNP-Pluronic F-127 gel was conducted in a rat model after induction of a Staphylococcus aureus ATCC 6538P wound infection. Results The formation of AgNPs was confirmed by ultraviolet-visible spectroscopy, where a surface-plasmon resonance absorption peak was observed between 432 and 438 nm. Both size and concentration of the formed AgNPs increased with increasing concentration of the extracts. The developed NPs were stable, almost spherical, and polydisperse, with a size range of 1.4–8.6 nm. The negative ζ-potential values, as well as Fourier-transform infrared spectroscopy analysis, indicated the presence of a capping agent adsorbed onto the surface of the particles. In vitro antimicrobial evaluation revealed a size-dependent activity of the AgNPs against the tested organisms. Finally, AgNPs prepared using 0.2% extract exhibited a substantial in vivo healing potential for full-thickness excision wounds in rats. Conclusion AgNPs were successfully synthesized from a silver nitrate solution through a simple green route, using cranberry powder aqueous extract as a reducing as well as capping agent.

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Section: Study Of Bacteria-killing Kineticsmentioning

confidence: 99%

Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties

Ashour

Raafat

El‐Gowelli

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…[48][49][50][51][52][53][54][55] (9) Anti-inflammatory properties of silver nanoparticles also promote wound healing by reducing cytokine release, 56 decreasing lymphocyte and mast cell infiltration. 57 …”

Section: Silver Nanoparticle Properties That Aid Wound Healingmentioning

confidence: 99%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

168

110

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Nanotechnology is on the threshold of providing a host of new materials and approaches, revolutionizing the medical and pharmaceutical fields. Several areas of medical care are already profiting from the advantage that nanotechnology offers. Recently, silver nanoparticles are attracting interest for a clinical application because of its potential biological properties such as antibacterial activity, anti-inflammatory effects, and wound healing efficacy, which could be exploited in developing better dressings for wounds and ulcers. This article reviews the role of silver nanoparticles in wound healing.

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“…As the development of the toxicology and pharmacology, especially regarding the effect of nanoparticles on cells, silver nanoparticles (AgNPs) [10][11][12][13][14][15][16][17][18] have showed the property of anti cancers. The report demonstrated that AgNPs can enter some cytoplasmic organoids by endocytosis 19 and agglomerate within the perinuclear region associated with the endo-lysosomal cell compartment.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanocrystals Mediated Combination Therapy of Radiation with Magnetic Hyperthermia on Glioma Cells

Jiang¹,

Wang²,

Guo³

et al. 2012

j nanosci nanotechnol

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Based on the study of apoptosis-induced and anti-proliferation behavior of silver nanoparticles (AgNPs) on cancer cells, the attractively therapeutic effect and potential application of AgNPs in anti-cancer field was gradually revealed. Here we investigated the effect of 10 nm silver nanoparticles (AgNPs) on human glioma U251 cells upon the combination treatment of ionizing radiation (IR) treatment with magnetic hyperthermia (MHT). AgNPs showed both radio and thermo sensitivity on U251 cells from the surviving fraction curve. Besides, we found both X-rays and heat could enhance the content of cells uptake of AgNPs. As the amount of intracellular AgNPs accumulated, the apoptosis rate of U251 cells enhanced. Furthermore, we established a simplified model for calculating cell survival rate and demonstrated that after RT, MHT and RT combined with MHT, AgNPs could significantly inhibited cancer cell proliferation. Our results revealed that AgNPs could have a potential application in enhancing effect of RT with MHT combination therapy induced killing of cancer cells.

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Superior Wound Healing Effect of Topically Delivered Silver Nanoparticle Formulation Using Eco-Friendly Potato Plant Pathogenic Fungus: Synthesis and Characterization

Cited by 35 publications

References 0 publications

Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties

Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Silver Nanocrystals Mediated Combination Therapy of Radiation with Magnetic Hyperthermia on Glioma Cells

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